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91. 发明申请

US20130211734A1 Systems and Methods for Calculating Protein Confidence Values 审中-公开
标题翻译：用于计算蛋白质置信度的系统和方法
公开(公告)号：US20130211734A1
公开(公告)日：2013-08-15
申请号：US13697707
申请日：2011-05-12
申请人： Ignat V. Shilov
发明人： Ignat V. Shilov
IPC分类号： G06F19/00
CPC分类号： G16C20/20 , G16B40/10
摘要： Protein confidence values are calculated in proteomic analysis. A protein database is searched for proteins matching peptides found from mass spectrometry of a sample producing a set of proteins and a corresponding set of peptides. Peptide confidence values for the set of peptides are determined. Protein confidence values are calculated for the set of proteins based on the peptide confidence values. A protein is selected from the set of proteins with a largest protein confidence value, the largest protein confidence value is saved for the protein, the protein is removed from the set of proteins, and one or more peptides corresponding to the protein are removed from the set of peptides. Protein confidence values are recalculated for the set of proteins based on the peptide confidence values and an effect of removing the one or more peptides from the set of peptides.
摘要翻译：在蛋白质组学分析中计算蛋白质置信度值。搜索蛋白质数据库，从匹配产生一组蛋白质和相应肽组的样品的质谱的质谱图匹配的蛋白质。确定该组肽的肽置信度值。基于肽置信度值为蛋白质组计算蛋白质置信度值。蛋白质选自具有最大蛋白质置信度值的一组蛋白质，为蛋白质节省了最大的蛋白质置信度值，蛋白质从该组蛋白质中除去，并且从蛋白质相应的一个或多个肽从一套肽。基于肽置信度值和从该组肽中除去一种或多种肽的效果，对蛋白质组重新计算蛋白质置信度值。

92. 发明授权

US08501498B2 Mass tags for quantitative analyses 有权
标题翻译：用于定量分析的质量标签
公开(公告)号：US08501498B2
公开(公告)日：2013-08-06
申请号：US12618452
申请日：2009-11-13
申请人： Xiongwei Yan , Pau-Miau Yuan , Sylvia W. Yuen , Kuo-Liang Hsi , Joe Y. Lam , Krishna G. Upadhya , Subhakar Dey , Darryl J. C. Pappin , Sasi Pillai , Helena Huang , Subhasish Purkayastha
发明人： Xiongwei Yan , Pau-Miau Yuan , Sylvia W. Yuen , Kuo-Liang Hsi , Joe Y. Lam , Krishna G. Upadhya , Subhakar Dey , Darryl J. C. Pappin , Sasi Pillai , Helena Huang , Subhasish Purkayastha
IPC分类号： G01N33/532 , G01N33/534 , G01N33/533 , G01N24/00
CPC分类号： C07D295/185 , C07B2200/05 , C07D239/54 , C07D239/553 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , G01N33/6848 , G01N2458/15 , Y10T436/143333 , Y10T436/24
摘要： This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
摘要翻译：本发明涉及通过使用独特标记试剂或独特标记试剂组的质量分析来测定分析物的方法，混合物，试剂盒和/或组合物。标记试剂可以是异构体或同量异构体，并且可用于产生适于多重分析标记分析物的混合物。

93. 发明授权

US08389934B2 Heated time of flight source 有权
标题翻译：加热时间的飞行来源
公开(公告)号：US08389934B2
公开(公告)日：2013-03-05
申请号：US12732426
申请日：2010-03-26
申请人： Mihajlo Dzepina , William Loyd , Gregor Sprah
发明人： Mihajlo Dzepina , William Loyd , Gregor Sprah
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/067
摘要： A lens assembly for use in mass spectrometry and a method for reducing contaminant build up on ion optic components in a lens assembly for use in a mass spectrometer are disclosed herein. In various embodiments of applicant's teachings, the lens assembly comprises a plurality of ion optic components assembled to form an ion lens and a heater. The plurality of ion optic components has a generally similar expansion coefficient. The heater is operatively coupled to the ion optic components. The heater heats the ion optic components to reduce the accumulation of debris on the ion optic components. In various embodiments, the method includes receiving, in a lens assembly, ions from an ion source. The lens assembly includes a plurality of ion optic components assembled to form an ion lens, the plurality of ion optic components having a generally similar expansion coefficient. The method also comprises heating the ion optic components to a first temperature.
摘要翻译：本文公开了一种用于质谱的透镜组件和用于减少用于质谱仪的透镜组件中的离子光学部件上积聚的污染物的方法。在申请人的教导的各种实施例中，透镜组件包括组装成离子透镜和加热器的多个离子光学元件。多个离子光学元件具有大致相似的膨胀系数。加热器可操作地耦合到离子光学部件。加热器加热离子光学部件以减少离子光学部件上的碎屑积聚。在各种实施例中，该方法包括在透镜组件中接收离子源的离子。透镜组件包括组装成离子透镜的多个离子光学元件，该多个离子光学部件具有大致相似的膨胀系数。该方法还包括将离子光学元件加热至第一温度。

94. 发明授权

US08384024B2 Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis 有权
标题翻译：串联差示迁移率光谱仪和质谱仪用于增强分析
公开(公告)号：US08384024B2
公开(公告)日：2013-02-26
申请号：US12873493
申请日：2010-09-01
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Paul Vouros
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Paul Vouros
IPC分类号： H01J49/04
CPC分类号： G01N27/624
摘要： The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a differential mobility spectrometer in combination with a mass analyzer to enhance the analysis process of constituents of a sample.
摘要翻译：本发明一般涉及用于分析样品的系统，方法和装置，更具体地，涉及使用差示迁移率光谱仪与质量分析器组合以增强样品组分的分析过程的系统。

95. 发明授权

US08373117B2 Gas delivery system for mass spectrometer reaction and collision cells 有权
标题翻译：用于质谱仪反应和碰撞细胞的气体输送系统
公开(公告)号：US08373117B2
公开(公告)日：2013-02-12
申请号：US13032174
申请日：2011-02-22
申请人： Hamid R. Badiei , Kaveh Kahen
发明人： Hamid R. Badiei , Kaveh Kahen
IPC分类号： H01J49/24 , F16K11/10 , F16K11/00
CPC分类号： H01J49/105 , G05D7/0635 , H01J49/24 , Y10T137/877 , Y10T137/87877
摘要： A gas delivery system for a cell-based mass spectrometer includes a mass flow controller having an input coupled to a gas source. A three-way valve includes an input coupled to an output of the mass flow controller, a first output coupled to a vacuum system, and a second output normally coupled to a reaction or collision cell. A cell is positioned inside a vacuum chamber of the mass spectrometer where the second output of the three-way valve is coupled to an inlet of the cell and the mass flow controller provides a gas to the cell that increases a pressure inside the cell relative to the pressure in the vacuum chamber.
摘要翻译：用于基于细胞的质谱仪的气体输送系统包括具有耦合到气体源的输入的质量流量控制器。三通阀包括耦合到质量流量控制器的输出的输入端，耦合到真空系统的第一输出端，以及通常耦合到反应或碰撞单元的第二输出端。电池位于质谱仪的真空室内，其中三通阀的第二输出端连接到电池的入口，质量流量控制器向电池提供气体，该气体相对于电池相对于电池内的压力增加真空室内的压力。

96. 发明授权

US08309914B2 Method of operating a linear ion trap to provide low pressure short time high amplitude excitation with pulsed pressure 有权
标题翻译：操作线性离子阱以提供具有脉冲压力的低压短时间高振幅激励的方法
公开(公告)号：US08309914B2
公开(公告)日：2012-11-13
申请号：US12359526
申请日：2009-01-26
申请人： Mircea Guna , Yves Le Blanc , Bruce Collings
发明人： Mircea Guna , Yves Le Blanc , Bruce Collings
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/426 , H01J49/0063 , H01J49/24
摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10−5 Torr to about 5×10−4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.
摘要翻译：描述了在离子阱中分离离子的方法。这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的工作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供至少10％的离子阱内的工作压力的非稳态压力增加，以提高离子中的压力在第一升高压力持续时间内，在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留碎片的离子阱内的母离子。激发时间间隔和第一升高压力时间基本上在时间上重叠。

97. 发明申请

US20120280120A1 METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY 有权
标题翻译：具有可调分辨率和选择性的真空驱动质谱仪接口的方法和系统
公开(公告)号：US20120280120A1
公开(公告)日：2012-11-08
申请号：US13541414
申请日：2012-07-03
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/26 , H01J49/24
CPC分类号： H01J49/26 , G01N27/622 , H01J49/004 , H01J49/0404 , H01J49/0468 , H01J49/24
摘要： A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.
摘要翻译：提供了质谱仪系统及其操作方法。该系统包括用于接收离子的离子导管; 限定包含离子导管的帘式气室的边界构件; 用于向离子管道的入口提供帘式气体以提供气体流入管道中的帘式气体供应，以及帘式气体从帘式气体室入口流出; 至少部分地密封并与导管流体连通的用于从导管接收离子的质谱仪; 围绕质谱仪的真空室可操作以将包括离子的气流通过导管抽入真空室; 以及气体出口，用于从位于导管和质谱仪之间的气流拉出气体流出，以增加通过导管的气体流速。

98. 发明授权

US08236565B2 Tagging reagents and methods for hydroxylated compounds 有权
标题翻译：标记羟基化合物的试剂和方法
公开(公告)号：US08236565B2
公开(公告)日：2012-08-07
申请号：US11754929
申请日：2007-05-29
申请人： Subhasish Purkayastha , Subhakar Dey , Sasi Pillai
发明人： Subhasish Purkayastha , Subhakar Dey , Sasi Pillai
IPC分类号： G01N37/00
CPC分类号： C07C401/00 , C07B2200/05 , C07C269/02 , C07C271/64 , C07C405/00 , C07D295/15 , C07J43/00 , Y10T436/13
摘要： In various aspects, the present teachings provide labeling reagents and sets of labeling reagents for the relative quantitation, absolute quantitation, or both, of hydroxylated compounds including, but not limited to, hydroxylated ring containing compounds, steroids and sterols. In various aspects, the present teachings also provide methods for the analysis hydroxylated compounds including, but not limited to, hydroxylated ring containing compounds, steroids and sterols my MS/MS methods.
摘要翻译：在各个方面，本教导提供了羟基化化合物的相对定量，绝对定量或两者的标记试剂和标记试剂组，包括但不限于含羟基化的环化合物，类固醇和固醇。在各个方面，本教导还提供用于分析羟化化合物的方法，包括但不限于羟基化的环化合物，类固醇和固醇，我的MS / MS方法。

99. 发明授权

US08217344B2 Differential mobility spectrometer pre-filter assembly for a mass spectrometer 有权
标题翻译：用于质谱仪的差分迁移率光谱仪预过滤器组件
公开(公告)号：US08217344B2
公开(公告)日：2012-07-10
申请号：US12012053
申请日：2008-01-31
申请人： Raanan A. Miller , Erkinjon G. Nazarov
发明人： Raanan A. Miller , Erkinjon G. Nazarov
IPC分类号： H01J49/26
CPC分类号： H01J49/004 , G01N27/624
摘要： A pre-filter assembly including a differential mobility spectrometer (DMS) that is configured to be in-line with a mass spectrometer (MS) such that the MS continuously receives carrier flow from the DMS when the DMS filtering fields are removed.
摘要翻译：一种包括差分迁移谱仪（DMS）的预过滤器组件，其被配置为与质谱仪（MS）保持一致，使得当DMS过滤区域被去除时，MS连续接收来自DMS的载体流。

100. 发明授权

US08187893B2 Mass spectrometric based assay for presence of a protein without the use of a standard 有权
标题翻译：基于质谱法测定蛋白质的存在而不使用标准品
公开(公告)号：US08187893B2
公开(公告)日：2012-05-29
申请号：US12572042
申请日：2009-10-01
申请人： Christie L. Hunter
发明人： Christie L. Hunter
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , G01N30/7233 , Y10T436/105831 , Y10T436/24
摘要： The present teachings provide methods for the development of a mass spectrometric based assay for a protein in a sample using parent-daughter ion transition monitoring (PDITM). In various aspects, the present teachings provide methods for developing a mass spectrometric based assay for a protein in a sample without the use of a standard for the protein. In various embodiments, the sample comprises proteolytic fragments of a protein which is present in low abundance in the physiological fluid from which it is derived.
摘要翻译：本教导提供了使用亲 - 子离子跃迁监测（PDITM）开发用于样品中的蛋白质的基于质谱法的测定方法。在各个方面，本教导提供了开发用于样品中蛋白质的基于质谱法的测定方法而不使用蛋白质标准的方法。在各种实施方案中，样品包含蛋白质的蛋白水解片段，所述蛋白质蛋白质在其衍生的生理液体中的丰度低。

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