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11. 发明授权

US07326545B2 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US07326545B2
公开(公告)日：2008-02-05
申请号：US10324129
申请日：2002-12-20
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： C12P21/02 , A61K39/02 , A61K39/11 , C07H21/04 , C12N1/20
CPC分类号： A61K39/118 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/295 , C07K2319/01 , C07K2319/02 , E02D3/02 , Y10S530/811 , Y10S530/814 , Y10S530/82
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了一种核酸的方法，包括DNA，宿主（包括人）免疫针对由衣原体特异性肺炎衣原体感染引起的疾病，使用含有编码98kDa外膜的核苷酸序列的载体肺炎衣原体菌株的蛋白质和在宿主中表达98kDa外膜蛋白基因的启动子。在本发明的范围内可以进行修改。

12. 发明授权

US07285276B2 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US07285276B2
公开(公告)日：2007-10-23
申请号：US11107823
申请日：2005-04-18
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K39/00 , A61K39/02 , A61K39/118
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法使用肺炎衣原体菌株的60kDa富含半胱氨酸的膜蛋白。在本发明的范围内可以进行修改。

13. 外观设计

USD550864S1 Lamp 有权
公开(公告)号：USD550864S1
公开(公告)日：2007-09-11
申请号：US29286086
申请日：2007-04-23
申请人： Fred Hernandez, Jr. , Catherine M. Emerling , Joe Wang , Chin Shui Hsu
设计人： Fred Hernandez, Jr. , Catherine M. Emerling , Joe Wang , Chin Shui Hsu

14. 发明授权

US07183402B2 Chlamydia antigens and corresponding DNA fragments and uses thereof 失效
标题翻译：衣原体抗原和相应的DNA片段及其用途
公开(公告)号：US07183402B2
公开(公告)日：2007-02-27
申请号：US10976917
申请日：2004-11-01
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： C07H21/04 , C12N15/00 , A01N43/04
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide sequence encoding a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 60 kDa cysteine-rich membrane protein gene in the host. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供了包含DNA，宿主（包括人）在内的免疫针对由衣原体特异性肺炎衣原体感染引起的疾病的核酸的方法，其使用含有编码60kDa半胱氨酸 - 肺炎衣原体菌株的富含膜蛋白和在宿主中有效表达60kDa富含半胱氨酸的膜蛋白基因的启动子。在本发明的范围内可以进行修改。

15. 发明申请

US20120145898A1 PARTICLE DETECTION SYSTEM 有权
标题翻译：颗粒检测系统
公开(公告)号：US20120145898A1
公开(公告)日：2012-06-14
申请号：US12968229
申请日：2010-12-14
申请人： YI-XIANG WANG , JOE WANG , WEIMING REN
发明人： YI-XIANG WANG , JOE WANG , WEIMING REN
IPC分类号： G21K7/00 , H01J3/14
CPC分类号： H01J37/244 , H01J37/28 , H01J2237/24435 , H01J2237/2444 , H01J2237/2449
摘要： This invention provides a design to process a large range of detection beam current at low noise with a single detector. With such a design, the detection system can generate up to 1010 gain and maximum signal output at more than mini Ampere (mA) level. A condenser lens is configured to increase bandwidth of the detector that scan speed can be enhanced.
摘要翻译：本发明提供了利用单个检测器处理低噪声的大范围检测光束电流的设计。通过这样的设计，检测系统可以以超过小于安培（mA）的电平产生多达1010个增益和最大信号输出。配置聚光透镜以增加检测器的带宽，可以提高扫描速度。

16. 发明申请

US20110260055A1 Dynamic Focus Adjustment with Optical Height Detection Apparatus in Electron Beam system 有权
标题翻译：电子束系统中光学高度检测装置的动态聚焦调整
公开(公告)号：US20110260055A1
公开(公告)日：2011-10-27
申请号：US12764902
申请日：2010-04-21
申请人： JOE WANG , VAN-DUC NGUYEN , YI-XIANG WANG , JACK JAU , ZHONGWEI CHEN
发明人： JOE WANG , VAN-DUC NGUYEN , YI-XIANG WANG , JACK JAU , ZHONGWEI CHEN
IPC分类号： H01J37/21 , G01N23/22 , G01B11/24 , H01J37/28
CPC分类号： G01B11/22 , G01N23/04 , G01N23/20058 , G01N2223/32 , G01N2223/3301 , G01N2223/3302 , G01N2223/646 , H01J37/21 , H01J37/28 , H01J2237/216 , H01J2237/2482 , H01J2237/2487
摘要： The present invention generally relates to dynamic focus adjustment for an image system. With the assistance of a height detection sub-system, present invention provides an apparatus and methods for micro adjusting an image focusing according the specimen surface height variation by altering the field strength of an electrostatic lens between objective lens and sample stage/or a bias voltage applied to the sample surface. Merely by way of example, the invention has been applied to a scanning electron inspection system. But it would be recognized that the invention could apply to other system using charged particle beam as observation tool with a height detection apparatus.
摘要翻译：本发明一般涉及图像系统的动态聚焦调整。本发明借助于高度检测子系统，提供了一种用于通过改变物镜和样品台之间的静电透镜的场强/或偏置电压来根据样本表面高度变化来微调整图像聚焦的装置和方法应用于样品表面。仅作为示例，本发明已经应用于扫描电子检查系统。但是应当认识到，本发明可以应用于使用带有带电粒子束的其它系统作为具有高度检测装置的观察工具。

17. 发明授权

US07796833B2 Method for spectral data classification and detection in diverse lighting conditions 失效
标题翻译：在不同照明条件下进行光谱数据分类和检测的方法
公开(公告)号：US07796833B2
公开(公告)日：2010-09-14
申请号：US11676225
申请日：2007-02-16
申请人： Leonid Polonskiy , Zhu Joe Wang , Jasenka Benac , Jeffry Golden
发明人： Leonid Polonskiy , Zhu Joe Wang , Jasenka Benac , Jeffry Golden
IPC分类号： G06K9/40 , G06K9/46 , G06K9/62 , G06K9/00
CPC分类号： G01J3/28 , G01J3/2823 , G01N21/25 , G01N21/274 , G01N2021/1793 , G06K9/0063
摘要： The invention is a method of spectral data classification that uses the decoupling of target chromaticity and lighting or illumination chromaticity in spectral data and the sorting and selection of spectral bands by values of a merit function to obtain an optimized set of combinations of spectral bands for classification of the data. The decoupling is performed in “delta-log” space. A rotation transform may be applied. For a broad range of parameters, correction of lighting chromaticity may be obtained by use of an equivalent “Planck distribution” temperature. Merit function sorting and band combination selection is performed by multiple selection criteria. The method achieves reliable pixel classification and target detection in diverse lighting or illumination, especially in circumstances where lighting is non-uniform across a scene, such as with sunlight and shadows on a partly cloudy day or in “artificial” lighting. Applications are found in homeland security, defense, environmental protection, biomedical diagnostics, industrial process and product monitoring, and other remote or standoff sensing by spectral characteristics.
摘要翻译：本发明是一种光谱数据分类的方法，其使用光谱数据中的目标色度和照明或照明色度的去耦，以及通过优值函数的值分类和选择光谱带，以获得用于分类的光谱带的组合的优化集合的数据。去耦在“delta-log”空间中执行。可以应用旋转变换。对于广泛的参数，可以通过使用等效的“普朗克分布”温度来获得照明色度的校正。功能排序和乐队组合选择由多种选择标准进行。该方法在不同的照明或照明中实现可靠的像素分类和目标检测，特别是在场景照明不均匀的情况下，例如在部分多云的日子或“人造”照明中的阳光和阴影的情况下。应用于国土安全，防御，环境保护，生物医学诊断，工业过程和产品监控以及其他通过光谱特性的远程或间隔检测。

18. 发明申请

US20100150429A1 E-BEAM DEFECT REVIEW SYSTEM 有权
标题翻译：电子束缺陷评估系统
公开(公告)号：US20100150429A1
公开(公告)日：2010-06-17
申请号：US12335458
申请日：2008-12-15
申请人： Jack JAU , Zhongwei CHEN , Yi Xiang WANG , Chung-Shih PAN , Joe WANG , Xuedong LIU , Weiming REN , Wei FANG
发明人： Jack JAU , Zhongwei CHEN , Yi Xiang WANG , Chung-Shih PAN , Joe WANG , Xuedong LIU , Weiming REN , Wei FANG
IPC分类号： G06K9/00
CPC分类号： G06T7/001 , G01N23/04 , G01N2223/102 , G01N2223/426 , G01N2223/611 , G06T2207/10061 , G06T2207/30148
摘要： The present invention relates to a defect review system, and/or particularly, to an apparatus and method of defect review sampling, review method and classification on a semiconductor wafer or a pattern lithography reticle during integrated circuit fabrication. These objects are achieved in comparing a reviewed image with a reference image pick-up through a smart sampling filter. A clustering computer system base on high speed network will provide data cache and save operation time and memory. A smart review sampling filter automatically relocate abnormal pattern or defects and classify the device location extracted from design database and/or from golden die image on the same substrate. The column of the present defect review system is comprised of the modified SORIL type objective lens. This column provides solution of improving throughput during sample review, material identification better image quality, and topography image of defect. One embodiment of the present invent adopts an optical auto focusing system to compromise micro height variation due wafer surface topography. And another embodiment adopts surface charge control system to regulate the charge accumulation due to electron irradiation during the review process.
摘要翻译：本发明涉及一种缺陷评估系统，和/或特别涉及在集成电路制造期间对半导体晶片或图案光刻掩模版进行缺陷评估抽样，评估方法和分类的装置和方法。通过智能采样滤波器将经检查的图像与参考图像拾取进行比较，实现了这些目的。基于高速网络的集群计算机系统将提供数据缓存，节省操作时间和内存。智能检查采样过滤器自动重新定位异常模式或缺陷，并将从设计数据库中提取的设备位置和/或从相同基板上的金色模具图像分类。本缺陷检查系统的列由改进的SORIL型物镜组成。该栏提供了在样本审查期间提高吞吐量，材料识别更好的图像质量和缺陷的地形图像的解决方案。本发明的一个实施例采用光学自动聚焦系统来破坏由晶片表面形貌引起的微高度变化。另一个实施例采用表面电荷控制系统来调节在检查过程中由电子辐射引起的电荷累积。

19. 发明授权

US07629327B2 Chlamydia 60 Kda CRMP antigens and vaccine uses 失效
标题翻译：衣原体60 Kda CRMP抗原和疫苗用途
公开(公告)号：US07629327B2
公开(公告)日：2009-12-08
申请号：US11898220
申请日：2007-09-11
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang , Pamela Dunn
IPC分类号： A61K31/70
CPC分类号： A61K31/711 , A61K39/118 , A61K2039/53 , C07K14/295 , Y10S435/975
摘要： The present invention provides vaccines and methods for immunizing a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The vaccine and method employ a 60 kDa cysteine-rich membrane protein of a strain of Chlamydia pneumoniae. Modifications are possible within the scope of this invention.
摘要翻译：本发明提供用于免疫宿主（包括人）免疫衣原体特异性肺炎衣原体感染引起的疾病的疫苗和方法。疫苗和方法使用肺炎衣原体菌株的60kDa富含半胱氨酸的膜蛋白。在本发明的范围内可以进行修改。

20. 发明授权

US07553493B2 Chlamydia flagellar protein antigen 有权
标题翻译：衣原体鞭毛蛋白抗原
公开(公告)号：US07553493B2
公开(公告)日：2009-06-30
申请号：US11905430
申请日：2007-10-01
申请人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang
发明人： Andrew D. Murdin , Raymond P. Oomen , Joe Wang
IPC分类号： A61K39/118 , A61K39/02 , C12P21/04 , C12P21/06 , C07H21/04
CPC分类号： G01N33/56927 , A61K39/00 , C07K14/295 , C07K2319/00 , Y02A50/472 , Y02A50/476
摘要： The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia infection. In one form of the invention, the polynucleotide molecules encode polypeptides CPN100988 RY-68 (SEQ ID Nos:13 and 26).
摘要翻译：本发明提供了编码衣原体多肽的纯化和分离的多核苷酸分子，其可用于预防，治疗和诊断衣原体感染的方法。在本发明的一种形式中，多核苷酸分子编码多肽CPN100988 RY-68（SEQ ID NO：13和26）。

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