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1. 发明授权

US07858928B2 Nanostructured surfaces as a dual ionization LDI-DESI platform for increased peptide coverage in proteomic analysis 失效
标题翻译：纳米结构表面作为双电离LDI-DESI平台，用于在蛋白质组学分析中增加肽覆盖
公开(公告)号：US07858928B2
公开(公告)日：2010-12-28
申请号：US11858859
申请日：2007-09-20
申请人： Daniel R. Knapp
发明人： Daniel R. Knapp
IPC分类号： H01J49/04
CPC分类号： H01J49/0418 , H01J49/0463
摘要： Embodiments of the invention include methods and devices for the analysis of proteins utilizing a gold coated nanoporous alumina surface for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). Combined use of DESI and LDI gives increased sequence coverage in peptide mixture analysis from a single sample preparation.
摘要翻译：本发明的实施方案包括使用镀金纳米多孔氧化铝表面分析蛋白质的方法和装置，用于使用解吸电喷雾离子化（DESI）和激光解吸电离（LDI）进行双电离模式质谱分析。组合使用DESI和LDI从单个样品制备的肽混合物分析中提供了更高的序列覆盖率。

2. 发明授权

US4795715A Aminoalkoxy or carboxyalkoxy derivatives of propranolol for immunoassay applications 失效
标题翻译：普萘洛尔的氨基烷氧基或羧基烷氧基衍生物用于免疫测定
公开(公告)号：US4795715A
公开(公告)日：1989-01-03
申请号：US901772
申请日：1986-10-03
申请人： Thomas D. Eller , Daniel R. Knapp
发明人： Thomas D. Eller , Daniel R. Knapp
IPC分类号： G01N33/94 , G01N33/53
CPC分类号： G01N33/9453 , Y10S436/804 , Y10S530/806
摘要： Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4',5',6',7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
摘要翻译：普萘洛尔的衍生物具有以下结构：其中R是X-（CH 2）n O，X是NH 2或COOH，n是1,2,3,4或5，条件是当n是1时，X必须为COOH，R为4'，5'，6'，7'或8'位置。这些化合物可用于免疫测定应用，以（1）与蛋白质载体缀合，以制备针对普萘洛尔的抗体，和（2）与示踪剂部分如放射性标记的配体，酶，酶底物或荧光染料缀合。

3. 发明授权

US4652681A Aminoalkoxy derivatives of propranolol for immunoassay applications 失效
标题翻译：普萘洛尔的氨基烷氧基衍生物用于免疫测定
公开(公告)号：US4652681A
公开(公告)日：1987-03-24
申请号：US368672
申请日：1982-04-15
申请人： Thomas D. Eller , Daniel R. Knapp
发明人： Thomas D. Eller , Daniel R. Knapp
IPC分类号： G01N33/94 , C07C93/06
CPC分类号： G01N33/9453
摘要： Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4', 5', 6', 7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
摘要翻译：普萘洛尔的衍生物具有以下结构：其中R是X-（CH 2）n O，X是NH 2或COOH，n是1,2,3,4或5，条件是当n是1时，X必须为COOH，R为4'，5'，6'，7'或8'位置。这些化合物可用于免疫测定应用，以（1）与蛋白质载体缀合，以制备针对普萘洛尔的抗体，和（2）与示踪剂部分如放射性标记的配体，酶，酶底物或荧光染料缀合。

4. 发明授权

US07087895B1 Electrospray ionization using pointed fibers 失效
标题翻译：使用尖锐纤维进行电喷雾电离
公开(公告)号：US07087895B1
公开(公告)日：2006-08-08
申请号：US10862803
申请日：2004-06-07
申请人： Jian Liu , Daniel R. Knapp
发明人： Jian Liu , Daniel R. Knapp
IPC分类号： H01J49/00
CPC分类号： H01J49/167
摘要： A pointed carbon fiber electrospray ionization emitter has a length of electrically conductive fiber that is present within a lumen of a microfluidic device, and protrudes from the terminus. A point is present on an end of the electrically conductive fiber, or the electrically conductive fiber is otherwise sufficiently small on the end to create a desired spray. A conductor supplies electrical current to the electrically conductive fiber. Fluid to be sprayed is transported through the lumen and out of the terminus of the lumen, and an electrical field established by the conductive fiber distributes and sprays the fluid. The emitter is rugged and is able to generate stable electrospray over a wide range of flow rates, voltages, and surface tension variations.
摘要翻译：尖碳纤维电喷射电离发射器具有一定长度的导电纤维，其存在于微流体装置的内腔内，并从末端突出。一个点存在于导电纤维的一端，或者导电纤维的另一端足够小，以产生所需的喷雾。导体向导电纤维提供电流。要喷射的流体通过管腔输送到管腔的末端，并且由导电纤维建立的电场分布并喷射流体。发射极坚固，能够在宽范围的流速，电压和表面张力变化下产生稳定的电喷雾。

5. 发明授权

US4695647A Aromatic derivatives of 13-azaprostanoic acid 失效
标题翻译： 13-氮杂前列腺酸的芳香族衍生物
公开(公告)号：US4695647A
公开(公告)日：1987-09-22
申请号：US592074
申请日：1984-03-22
申请人： Thomas D. Eller , Perry V. Halushka , Daniel R. Knapp , Dale Mais
发明人： Thomas D. Eller , Perry V. Halushka , Daniel R. Knapp , Dale Mais
IPC分类号： C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C405/0033 , C07C405/0041 , C07C405/0091
摘要： Novel substituted phenyl eicosanoid analogs having the formula: ##STR1## and their pharmaceutically acceptable esters and salts, wherein: R is H or OH;R.sub.1 is H or lower alkyl;X is --CH.sub.2 --CH.sub.2 -- or cis --CH.dbd.CH--;Y is --CH.sub.2 --, ##STR2## --O-- or --S--; n is 0 or 1; and .circle.A is (1) an eicosanoid nucleus (ring system), (2) a carbocyclic analog of an eicosanoid nucleus or (3) a heterocyclic analog of an eicosanoid nucleus wherein one of the carbons in a carbocyclic analog is replaced by O, S or N.
摘要翻译：具有下式的新型取代的苯基类花生酸类似物及其药学上可接受的酯和盐，其中：R是H或OH; R1是H或低级烷基; X是-CH 2 -CH 2 - 或顺式-CH = CH-; Y是-CH2-， -O-或-S-; n为0或1; 和＆cir＆A是（1）类二十烷酸核（环系），（2）类花生酸核的碳环类似物或（3）类二十烷酸核的杂环类似物，其中碳环类似物中的一个碳被O取代， S或N.

6. 发明授权

US09881698B2 Planar geometry inertial electrostatic confinement fusion device 有权
公开(公告)号：US09881698B2
公开(公告)日：2018-01-30
申请号：US14477334
申请日：2014-09-04
申请人： Daniel R Knapp
发明人： Daniel R Knapp
IPC分类号： G21B1/11 , G21B1/03 , G21B3/00 , H05H1/03
CPC分类号： G21B1/11 , G21B1/03 , G21B3/006 , H05H1/03 , Y02E30/14
摘要： The systems and methods described herein relate to the use of electrostatic elements to confine and circulate ions in trapped orbits so as to facilitate ion-ion and ion-neutral collisions resulting in nuclear fusion reactions. The systems employ a disc shaped cloud of ions wherein the turning region for the recirculating ions are located in a circular space around the periphery of the disc-shaped ion cloud, thereby maximizing the turning space region to increase the number of ions trapped in the device compared to discrete beam devices, which in turn enables higher fusion yield compared to prior art devices.

7. 发明申请

US20160071621A1 Planar Geomertry Inertial Electrostatic confinement Fusion Device 审中-公开
标题翻译：平面地球惯性静电约束聚变装置
公开(公告)号：US20160071621A1
公开(公告)日：2016-03-10
申请号：US14477334
申请日：2014-09-04
申请人： Daniel R. Knapp
发明人： Daniel R. Knapp
IPC分类号： G21B1/11
CPC分类号： G21B1/11 , G21B1/03 , G21B3/006 , H05H1/03 , Y02E30/14
摘要： The systems and methods described herein relate to the use of electrostatic elements to confine and circulate ions in trapped orbits so as to facilitate ion-ion and ion-neutral collisions resulting in nuclear fusion reactions. The systems employ a disc shaped cloud of ions wherein the turning region for the recirculating ions are located in a circular space around the periphery of the disc-shaped ion cloud, thereby maximizing the turning space region to increase the number of ions trapped in the device compared to discrete beam devices, which in turn enables higher fusion yield compared to prior art devices.
摘要翻译：本文所述的系统和方法涉及使用静电元件将离子限制和循环在捕获的轨道中，以便于导致核聚变反应的离子 - 离子和离子 - 中性碰撞。这些系统采用圆盘形离子云，其中用于再循环离子的转动区域位于圆盘形离子云周围的圆形空间中，从而最大化转向空间区域以增加捕获在该装置中的离子数与离散束装置相比，这又与现有技术装置相比能够实现更高的熔化产量。

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