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1. 发明授权

US09442282B2 Organism sample observation device 有权
标题翻译：有机体样品观察装置
公开(公告)号：US09442282B2
公开(公告)日：2016-09-13
申请号：US13251673
申请日：2011-10-03
申请人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Ryuji Koshiba , Takayuki Uozumi
发明人： Hideo Kuroda , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Ryuji Koshiba , Takayuki Uozumi
IPC分类号： G02B21/36 , G01N21/64 , G02B21/16
CPC分类号： G02B21/367 , G01N21/6486 , G02B21/16 , G02B21/365 , G06K9/00134 , G06K9/0014
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.
摘要翻译：可以准确地进行生物样本的观察的生物样本观察装置。在宏观观察中，从宏观图像提取生物变化区域，登记与提取的生物体变化区域对应的微观观察点，并且识别跟踪对象。在微观观察中，从微观图像判断微观察点处的生物变化区域的生物变化是否持续，并且基于该判断结果来更新登记的微观察点。可以进行用于检测生物变化区域的宏观观察和用于观察已经显示生物学变化的部分微小区域的生长进展的微观察，并进行生物样本的准确观察。

2. 发明授权

US08947518B2 Cell observing apparatus and cell incubation method 有权
标题翻译：细胞观察装置和细胞培养方法
公开(公告)号：US08947518B2
公开(公告)日：2015-02-03
申请号：US13552839
申请日：2012-07-19
申请人： Yasujiro Kiyota , Takayuki Uozumi
发明人： Yasujiro Kiyota , Takayuki Uozumi
IPC分类号： H04N9/47 , H04N7/18 , C12M1/34 , G02B21/00 , G02B21/32 , G02B21/36
CPC分类号： C12M41/36 , G02B21/0088 , G02B21/32 , G02B21/36
摘要： User's time and labor required for performing manipulations with respect to cells which exist in an incubation container, are reduced. To achieve the above, a cell observing apparatus includes an observation stage supporting an incubation container that houses cells, a micro imaging optical system forming, on an imaging device for micro imaging, an image of the cell in the incubation container disposed at an observing position of the observation stage, a macro imaging optical system forming, on an imaging device for macro imaging, an image of an area wider than that captured by the micro imaging optical system in the incubation container, and a controlling unit controlling an operation of a manipulation needle that manipulates the cells in the incubation container, in which the micro imaging optical system is disposed on a side facing the macro imaging optical system with the observation stage being located therebetween.
摘要翻译：对于存在于孵育容器中的细胞进行操作所需的用户时间和劳动力减少。为了实现上述目的，细胞观察装置包括：支持容纳细胞的培养容器的观察台，在微成像用成像装置上形成在设置在观察位置的培养容器中的细胞的图像的微成像光学系统在宏观成像装置上形成比由培养容器中的微成像光学系统捕获的区域宽的区域的图像的宏观成像光学系统，以及控制操作的控制单元操纵培养容器中的细胞的针，其中微成像光学系统设置在面向宏观成像光学系统的一侧，观察台位于其间。

3. 发明申请

US20090068728A1 Cell incubator 审中-公开
标题翻译：细胞培养箱
公开(公告)号：US20090068728A1
公开(公告)日：2009-03-12
申请号：US12230258
申请日：2008-08-26
申请人： Yasujiro KIYOTA , Takayuki Uozumi
发明人： Yasujiro KIYOTA , Takayuki Uozumi
IPC分类号： C12M3/00
CPC分类号： C12M41/14 , C12M41/36 , G02B7/38
摘要： A cell incubator having an observation unit to observe a cell incubation process comprises: a focus detecting unit to detect a focus position of an imaging optical system of the observation unit; an optimum focus selecting unit to select an optimum focus position based upon a plurality of images taken by moving the imaging optical system stepwise at a fine pitch along an optical axis direction from the focus position, based upon the focus position detected by the focus detecting unit; and a fluorescence observation unit to shoot a fluorescence image of the cells by moving the imaging optical system to the optimum focus position thus detected by the optimum focus selecting unit.
摘要翻译：具有用于观察细胞培养过程的观察单元的细胞培养箱包括：焦点检测单元，用于检测观察单元的成像光学系统的焦点位置; 最佳焦点选择单元，基于由焦点检测单元检测到的对焦位置，基于通过沿着光轴方向以微小间距逐渐地从聚焦位置逐步移动成像光学系统而获取的多个图像来选择最佳聚焦位置; ; 以及荧光观察单元，通过将成像光学系统移动到由最佳聚焦选择单元检测到的最佳聚焦位置来拍摄细胞的荧光图像。

4. 发明授权

US09340764B2 Transfer device for culture vessel, culture device and holder for culture vessel 有权
标题翻译：用于培养容器，培养装置和培养容器用保持器的转移装置
公开(公告)号：US09340764B2
公开(公告)日：2016-05-17
申请号：US11921077
申请日：2006-06-27
申请人： Takayuki Uozumi , Yasujiro Kiyota , Nobuhiko Maiya , Hirofumi Shiono
发明人： Takayuki Uozumi , Yasujiro Kiyota , Nobuhiko Maiya , Hirofumi Shiono
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/52 , C12M23/48 , C12M23/50 , C12M41/48
摘要： A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a transferring unit transferring a culture vessel for culturing a cell, an inputting unit inputting a kind of the culture vessel, a speed setting unit setting a transfer speed of the culture vessel based on a kind of the culture vessel inputted to the inputting unit, and a controlling unit controlling a transfer speed of the transferring unit to be the transfer speed set by the speed setting unit.
摘要翻译：用于转移培养细胞的培养容器的培养容器的转移装置，包括用于培养容器的转移装置的培养装置和用于保持培养容器的培养容器的保持器，其中用于培养的转移装置容器包括：转移单元，其传送用于培养细胞的培养容器;输入单元，输入培养容器的种类;速度设定单元，基于输入到输入单元的培养容器的种类，设定培养容器的传送速度; 以及控制单元，其将所述传送单元的传送速度控制为由所述速度设定单元设定的传送速度。

5. 发明申请

US20130027539A1 CELL OBSERVING APPARATUS AND CELL INTEGRATION METHOD 有权
标题翻译：细胞观察装置和细胞整合方法
公开(公告)号：US20130027539A1
公开(公告)日：2013-01-31
申请号：US13552839
申请日：2012-07-19
申请人： Yasujiro KIYOTA , Takayuki Uozumi
发明人： Yasujiro KIYOTA , Takayuki Uozumi
IPC分类号： H04N7/18
CPC分类号： C12M41/36 , G02B21/0088 , G02B21/32 , G02B21/36
摘要： User's time and labor required for performing manipulations with respect to cells which exist in an incubation container, are reduced. To achieve the above, a cell observing apparatus includes an observation stage supporting an incubation container that houses cells, a micro imaging optical system forming, on an imaging device for micro imaging, an image of the cell in the incubation container disposed at an observing position of the observation stage, a macro imaging optical system forming, on an imaging device for macro imaging, an image of an area wider than that captured by the micro imaging optical system in the incubation container, and a controlling unit controlling an operation of a manipulation needle that manipulates the cells in the incubation container, in which the micro imaging optical system is disposed on a side facing the macro imaging optical system with the observation stage being located therebetween.
摘要翻译：对于存在于孵育容器中的细胞进行操作所需的用户时间和劳动力减少。为了实现上述目的，细胞观察装置包括：支持容纳细胞的培养容器的观察台，在微成像用成像装置上形成在设置在观察位置的培养容器中的细胞的图像的微成像光学系统在宏观成像装置上形成比由培养容器中的微成像光学系统捕获的区域宽的区域的图像的宏观成像光学系统，以及控制操作的控制单元操纵培养容器中的细胞的针，其中微成像光学系统设置在面向宏观成像光学系统的一侧，观察台位于其间。

6. 发明授权

US08192983B2 Incubator 有权
标题翻译：孵化器
公开(公告)号：US08192983B2
公开(公告)日：2012-06-05
申请号：US11921874
申请日：2006-06-23
申请人： Yasujiro Kiyota , Takayuki Uozumi , Nobuhiko Maiya , Hirofumi Shiono
发明人： Yasujiro Kiyota , Takayuki Uozumi , Nobuhiko Maiya , Hirofumi Shiono
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M41/48 , C12M41/14
摘要： An incubator including a temperature-controlled room adjusted to a predetermined environment condition for culturing a sample of an incubation container at inside of the temperature-controlled room, the incubator including a shifting mechanism for moving a position of the incubation container at inside of the temperature-controlled room by a motor, a temperature adjusting section for adjusting a temperature at inside of the temperature-controlled room, an operating information generating section for generating operating information with regard to a position of operating and a time period of operating the motor prior to operating the motor, an estimated variation outputting section for outputting an estimation variation of a temperature state by operating the motor based on the operating information, and a controlling section for controlling the temperature adjusting section to cancel a temperature change of an amount of the estimated variation in synchronism with operating the motor.
摘要翻译：一种培养箱，其包括温度调节室，其被调节到预定的环境条件，用于在温度控制室内部培养培养容器的样品，所述培养箱包括移动机构，用于在所述温度的内部移动所述培养容器的位置由电动机控制的房间，用于调节在温度控制室内部的温度的温度调节部分;操作信息产生部分，用于产生关于操作位置的操作信息和在电动机之前操作电动机的时间段估计变化输出部分，用于通过基于操作信息操作马达来输出温度状态的估计变化;以及控制部分，用于控制温度调节部分，以消除估计变化量的温度变化与操作电机同步。

7. 发明授权

US07968330B2 Culture observation equipment 有权
标题翻译：文化观察设备
公开(公告)号：US07968330B2
公开(公告)日：2011-06-28
申请号：US12216885
申请日：2008-07-11
申请人： Kyoji Nakamura , Takayuki Uozumi
发明人： Kyoji Nakamura , Takayuki Uozumi
IPC分类号： C12M1/34 , C12M3/00 , G02B21/00
CPC分类号： C12M41/36 , C12M23/50 , C12M41/14
摘要： The present application includes a culture chamber, an observation chamber having an optical system of observation to observe samples to be cultured in the culture chamber, and a movement stage provided at a boundary which separates the culture chamber and the observation chamber, functioning as a wall to maintain an environment of both of the chambers, bearing the samples, and moving the samples on a light axis of observation of the optical system of observation. Due to such an arrangement, a culture observation equipment which has good response and excellent environmental resistance can be achieved, preventing problems such as the overall size of the device became large, maintenance work was difficult, and device cost became expensive.
摘要翻译：本申请包括培养室，具有观察用光学系统的观察室，以观察培养室中培养的样品，以及设置在分隔培养室和观察室的边界的移动台，其作为壁以维持两个室的环境，承载样品，并且在观察光学系统的观察的光轴上移动样品。由于这样的布置，可以实现具有良好的响应性和优异的耐环境性的文化观察装置，防止装置的整体尺寸等问题变大，维修工作困难，装置成本昂贵。

8. 发明申请

US20090154788A1 AUTOMATIC SYSTEM FOR JUDGING QUALITY OF CELL 有权
标题翻译：用于判断细胞质量的自动系统
公开(公告)号：US20090154788A1
公开(公告)日：2009-06-18
申请号：US12001872
申请日：2007-12-13
申请人： Nobuhiko Maiya , Yasujiro Kiyota , Takayuki Uozumi , Hirofumi Shiono
发明人： Nobuhiko Maiya , Yasujiro Kiyota , Takayuki Uozumi , Hirofumi Shiono
IPC分类号： G06K9/62
CPC分类号： G06K9/00127
摘要： An automatic culture device 1 having an automatic quality determination system is equipped with an analysis program 12. The analysis program 12 extracts cell characteristics from a captured image of a cell by driving a characteristic quantity extraction program 13, which is an image processing program for extracting characteristics (characteristic quantities) of this cell. The quality of the cell is then determined from the extracted characteristic or a combination of a plurality of characteristics by driving an identification program 15 that determines the quality of a cell. This allows cell quality determination to be automated.
摘要翻译：具有自动质量确定系统的自动培养装置1配备有分析程序12.分析程序12通过驱动作为提取的图像处理程序的特征量提取程序13从单元的拍摄图像中提取单元特性特征（特征量）。然后通过驱动确定单元质量的识别程序15，从所提取的特性或多个特征的组合确定单元的质量。这允许细胞质量确定自动化。

9. 发明申请

US20080293131A1 Culture observation equipment 有权
标题翻译：文化观察设备
公开(公告)号：US20080293131A1
公开(公告)日：2008-11-27
申请号：US12216885
申请日：2008-07-11
申请人： Kyoji Nakamura , Takayuki Uozumi
发明人： Kyoji Nakamura , Takayuki Uozumi
IPC分类号： C12M3/00
CPC分类号： C12M41/36 , C12M23/50 , C12M41/14
摘要： The present application includes a culture chamber, an observation chamber having an optical system of observation to observe samples to be cultured in the culture chamber, and a movement stage provided at a boundary which separates the culture chamber and the observation chamber, functioning as a wall to maintain an environment of both of the chambers, bearing the samples, and moving the samples on a light axis of observation of the optical system of observation. Due to such an arrangement, a culture observation equipment which has good response and excellent environmental resistance can be achieved, preventing problems such as the overall size of the device became large, maintenance work was difficult, and device cost became expensive.
摘要翻译：本申请包括培养室，具有观察用光学系统的观察室，以观察培养室中培养的样品，以及设置在分隔培养室和观察室的边界的移动台，其作为壁以维持两个室的环境，承载样品，并且在观察光学系统的观察的光轴上移动样品。由于这样的布置，可以实现具有良好的响应性和优异的耐环境性的文化观察装置，防止装置的整体尺寸等问题变大，维修工作困难，装置成本昂贵。

10. 发明授权

US09047502B2 Automatic system for judging quality of cell 有权
标题翻译：自动判断电池质量的系统
公开(公告)号：US09047502B2
公开(公告)日：2015-06-02
申请号：US12001872
申请日：2007-12-13
申请人： Nobuhiko Maiya , Yasujiro Kiyota , Takayuki Uozumi , Hirofumi Shiono
发明人： Nobuhiko Maiya , Yasujiro Kiyota , Takayuki Uozumi , Hirofumi Shiono
IPC分类号： G06K9/00
CPC分类号： G06K9/00127
摘要： An automatic culture device 1 having an automatic quality determination system is equipped with an analysis program 12. The analysis program 12 extracts cell characteristics from a captured image of a cell by driving a characteristic quantity extraction program 13, which is an image processing program for extracting characteristics (characteristic quantities) of this cell. The quality of the cell is then determined from the extracted characteristic or a combination of a plurality of characteristics by driving an identification program 15 that determines the quality of a cell. This allows cell quality determination to be automated.
摘要翻译：具有自动质量确定系统的自动培养装置1配备有分析程序12.分析程序12通过驱动作为提取的图像处理程序的特征量提取程序13从单元的拍摄图像中提取单元特性特征（特征量）。然后通过驱动确定单元质量的识别程序15，从所提取的特性或多个特征的组合确定单元的质量。这允许细胞质量确定自动化。

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