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1. 发明授权

US07957813B1 Adaptive staged wake-up for implantable medical device communication 有权
标题翻译：用于植入式医疗设备通信的自适应分级唤醒
公开(公告)号：US07957813B1
公开(公告)日：2011-06-07
申请号：US11745651
申请日：2007-05-08
申请人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
发明人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
IPC分类号： A61N1/00
CPC分类号： A61N1/37276
摘要： A communication wake-up scheme for an implantable medical device may involve repeatedly activating a receiver to determine whether an external device is attempting to establish communication with the implantable device. To reduce the amount of power consumed by the implantable device in conjunction with the wake-up scheme, the scheme may involve conducting preliminary radio frequency signal detections as a precursor to conducting a full scan. In this way, power may be conserved since the more power intensive full scans may be performed less frequently. This preliminary detection of radio frequency signals also may be adapted to reduce the number of full scans performed by the implantable device that do not result in communication with the external device. In some embodiments the adaptation involves adjusting one or more thresholds that are used in conjunction with the preliminary detection of radio frequency signals.
摘要翻译：用于可植入医疗设备的通信唤醒方案可以涉及重复激活接收器以确定外部设备是否正在尝试建立与可植入设备的通信。为了结合唤醒方案减少可植入装置消耗的功率量，该方案可以包括进行初步的射频信号检测作为进行全扫描的前兆。以这种方式，可以节省功率，因为可以执行较少的功率密集型全扫描较不频繁。射频信号的这种初步检测也可以适于减少不能导致与外部设备通信的可植入装置执行的全扫描的数量。在一些实施例中，适应涉及调整与射频信号的初步检测结合使用的一个或多个阈值。

2. 发明授权

US08386049B2 Adaptive staged wake-up for implantable medical device communication 有权
标题翻译：用于植入式医疗设备通信的自适应分级唤醒
公开(公告)号：US08386049B2
公开(公告)日：2013-02-26
申请号：US13095651
申请日：2011-04-27
申请人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
发明人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
IPC分类号： A61N1/00
CPC分类号： A61N1/37276
摘要： A communication wake-up scheme for an implantable medical device may involve repeatedly activating a receiver to determine whether an external device is attempting to establish communication with the implantable device. To reduce the amount of power consumed by the implantable device in conjunction with the wake-up scheme, the scheme may involve conducting preliminary RF signal detections as a precursor to conducting a full scan. In this way, power may be conserved since the more power intensive full scans may be performed less frequently. This preliminary detection of RF signals also may be adapted to reduce the number of full scans performed by the implantable device that do not result in communication with the external device. In some embodiments the adaptation involves adjusting one or more thresholds that are used in conjunction with the preliminary detection of RF signals. In some embodiments a wake-up scheme may involve scanning for signals using an initial RF band that is relatively wide, and then scanning for signals using narrower RF bands.
摘要翻译：用于可植入医疗设备的通信唤醒方案可以涉及重复激活接收器以确定外部设备是否正在尝试建立与可植入设备的通信。为了结合唤醒方案减少可植入装置消耗的功率量，该方案可以包括进行初步RF信号检测作为进行全扫描的前兆。以这种方式，可以节省功率，因为可以执行较少的功率密集型全扫描较不频繁。 RF信号的这种初步检测也可以适用于减少不能导致与外部设备通信的可植入设备进行的全扫描的数量。在一些实施例中，适配涉及调整与RF信号的初步检测结合使用的一个或多个阈值。在一些实施例中，唤醒方案可以包括使用相对宽的初始RF频带扫描信号，然后使用较窄的RF频带扫描信号。

3. 发明申请

US20110202113A1 ADAPTIVE STAGED WAKE-UP FOR IMPLANTABLE MEDICAL DEVICE COMMUNICATION 有权
标题翻译：用于可植入医疗设备通信的自适应标签唤醒
公开(公告)号：US20110202113A1
公开(公告)日：2011-08-18
申请号：US13095651
申请日：2011-04-27
申请人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
发明人： Benjamin T. Persson , Dorin Panescu , Dean Andersen
IPC分类号： A61N1/36
CPC分类号： A61N1/37276
摘要： A communication wake-up scheme for an implantable medical device may involve repeatedly activating a receiver to determine whether an external device is attempting to establish communication with the implantable device. To reduce the amount of power consumed by the implantable device in conjunction with the wake-up scheme, the scheme may involve conducting preliminary RF signal detections as a precursor to conducting a full scan. In this way, power may be conserved since the more power intensive full scans may be performed less frequently. This preliminary detection of RF signals also may be adapted to reduce the number of full scans performed by the implantable device that do not result in communication with the external device. In some embodiments the adaptation involves adjusting one or more thresholds that are used in conjunction with the preliminary detection of RF signals. In some embodiments a wake-up scheme may involve scanning for signals using an initial RF band that is relatively wide, and then scanning for signals using narrower RF bands.
摘要翻译：用于可植入医疗设备的通信唤醒方案可以涉及重复激活接收器以确定外部设备是否正在尝试建立与可植入设备的通信。为了结合唤醒方案减少可植入装置消耗的功率量，该方案可以包括进行初步RF信号检测作为进行全扫描的前兆。以这种方式，可以节省功率，因为可以执行较少的功率密集型全扫描较不频繁。 RF信号的这种初步检测也可以适用于减少不能导致与外部设备通信的可植入设备进行的全扫描的数量。在一些实施例中，适配涉及调整与RF信号的初步检测结合使用的一个或多个阈值。在一些实施例中，唤醒方案可以包括使用相对宽的初始RF频带扫描信号，然后使用较窄的RF频带扫描信号。

4. 发明申请

US20100023085A1 ADAPTABLE COMMUNICATION SENSITIVITY FOR AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：适用于可植入医疗器械的通信灵敏度
公开(公告)号：US20100023085A1
公开(公告)日：2010-01-28
申请号：US12179336
申请日：2008-07-24
申请人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
发明人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
IPC分类号： A61N1/375
CPC分类号： A61N1/37276 , H04W52/0245 , Y02D70/26
摘要： A wireless communication threshold for an implantable medical device is automatically adapted in an attempt to maintain optimum signal detection sensitivity. In some aspects, a threshold level may be adapted to account for current environmental conditions, implant conditions, device conditions, or other conditions that may affect the reception of wireless signals at the device. In some aspects, the determination of an optimum level for the threshold involves a tradeoff relating to effectively detecting target signals while avoiding detection of noise and/or interference. In some aspects, adaptation of a threshold may be based on maximum energy levels associated with one or more sets of RF energy sample data. In some aspects, adaptation of a threshold may be based on the number of false wakeups that occur during a period of time.
摘要翻译：可植入医疗装置的无线通信阈值自动适应于试图维持最佳信号检测灵敏度。在一些方面，阈值水平可以适应于考虑当前环境条件，植入条件，设备条件或可能影响在设备处的无线信号的接收的其他条件。在一些方面，确定阈值的最佳电平涉及与有效地检测目标信号有关的折中，同时避免噪声和/或干扰的检测。在一些方面，阈值的适应可以基于与一个或多个RF能量样本数据集相关联的最大能级。在一些方面，阈值的适应可以基于在一段时间内发生的假唤醒的数量。

5. 发明授权

US08554333B2 Adaptable communication sensitivity for an implantable medical device 有权
标题翻译：适用于植入式医疗设备的通信灵敏度
公开(公告)号：US08554333B2
公开(公告)日：2013-10-08
申请号：US12179336
申请日：2008-07-24
申请人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
发明人： Yongjian Wu , Benjamin T. Persson , Thanh Tieu , Dorin Panescu , Devanshi Shah , Lyle Frank Weaver
IPC分类号： A61N1/00 , H04L25/06 , H04Q5/22 , G08B1/08
CPC分类号： A61N1/37276 , H04W52/0245 , Y02D70/26
摘要： A wireless communication threshold for an implantable medical device is automatically adapted in an attempt to maintain optimum signal detection sensitivity. In some aspects, a threshold level may be adapted to account for current environmental conditions, implant conditions, device conditions, or other conditions that may affect the reception of wireless signals at the device. In some aspects, the determination of an optimum level for the threshold involves a tradeoff relating to effectively detecting target signals while avoiding detection of noise and/or interference. In some aspects, adaptation of a threshold may be based on maximum energy levels associated with one or more sets of RF energy sample data. In some aspects, adaptation of a threshold may be based on the number of false wakeups that occur during a period of time.
摘要翻译：可植入医疗装置的无线通信阈值自动适应于试图维持最佳信号检测灵敏度。在一些方面，阈值水平可以适应于考虑当前环境条件，植入条件，设备条件或可能影响在设备处的无线信号的接收的其他条件。在一些方面，确定阈值的最佳电平涉及与有效地检测目标信号有关的折中，同时避免噪声和/或干扰的检测。在一些方面，阈值的适应可以基于与一个或多个RF能量样本数据集相关联的最大能级。在一些方面，阈值的适应可以基于在一段时间内发生的假唤醒的数量。

6. 发明授权

US08868165B1 Use of cardiogenic impedance waveform morphology to analyze cardiac conditions and to adjust treatment therapy 有权
标题翻译：使用心源阻抗波形形态分析心脏状况并调整治疗疗法
公开(公告)号：US08868165B1
公开(公告)日：2014-10-21
申请号：US11863516
申请日：2007-09-28
申请人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
发明人： Yelena Nabutovsky , Dorin Panescu , Weiqun Yang , Mihir Naware
IPC分类号： A61B5/053 , A61B5/04
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/04 , A61B5/042 , A61B5/04525 , A61B5/0538 , A61B5/7246 , A61N1/3627 , A61N1/36521
摘要： In specific embodiments, one or more cardiogenic impedance signal template is stored, where each template has a corresponding morphology. Additionally, one or more cardiogenic impedance signal is obtained using electrodes implanted within a patient, where each signal has a corresponding morphology. The morphology of one or more obtained cardiogenic impedance signal is compared to the morphology of one or more stored template, to determine one or more metric indicative of similarity between the compared morphologies. The one or more metric indicative of similarity is used to analyze the patient's cardiac condition, to discriminate among arrhythmias and/or to adjust a cardiac pacing parameter.
摘要翻译：在具体实施例中，存储一个或多个心源阻抗信号模板，其中每个模板具有对应的形态。另外，使用植入患者体内的电极获得一个或多个心源性阻抗信号，其中每个信号具有相应的形态。将一个或多个获得的心源阻抗信号的形态与一个或多个存储的模板的形态进行比较，以确定指示比较形态之间的相似性的一个或多个度量。使用指示相似性的一个或多个度量来分析患者的心脏状况，区分心律失常和/或调整心脏起搏参数。

7. 发明授权

US08504153B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504153B2
公开(公告)日：2013-08-06
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

8. 发明授权

US08306623B2 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US08306623B2
公开(公告)日：2012-11-06
申请号：US13149507
申请日：2011-05-31
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia , Shahrooz Shahparnia
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

9. 发明授权

US08280511B2 Systems and methods for use by an implantable medical device for detecting heart failure based on the independent information content of immittance vectors 有权
标题翻译：由植入式医疗装置用于根据导纳矢量的独立信息内容检测心力衰竭的系统和方法
公开(公告)号：US08280511B2
公开(公告)日：2012-10-02
申请号：US12168750
申请日：2008-07-07
申请人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
发明人： Wenxia Zhao , Dorin Panescu , Anders Bjorling
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3627
摘要： Techniques are provided for detecting heart failure or other medical conditions within a patient using an implantable medical device, such as pacemaker or implantable cardioverter/defibrillator, or external system. In one example, physiological signals, such as immittance-based signals, are sensed within the patient along a plurality of different vectors, and the amount of independent informational content among the physiological signals of the different vectors is determined. Heart failure is then detected by the implantable device based on a significant increase in the amount of independent informational content among the physiological signals. In response, therapy may be controlled, diagnostic information stored, and/or warning signals generated. In other examples, at least some of these functions are performed by an external system.
摘要翻译：提供了用于使用可植入医疗装置（例如起搏器或植入式心律转复器/去纤颤器或外部系统）来检测患者心脏衰竭或其他医疗状况的技术。在一个示例中，沿着多个不同的向量在患者体内感测诸如基于导纳的信号的生理信号，并且确定不同矢量的生理信号中的独立信息内容的量。基于生理信号中独立信息内容量的显着增加，可植入装置检测心力衰竭。作为响应，可以控制治疗，存储诊断信息和/或生成警告信号。在其他示例中，这些功能中的至少一些由外部系统执行。

10. 发明授权

US07945326B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US07945326B1
公开(公告)日：2011-05-17
申请号：US11684677
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

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