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1. 发明申请

US20090317908A1 HIGHLY PACKED POLYCATIONIC AMMONIUM, SULFONIUM AND PHOSPHONIUM LIPIDS 审中-公开
标题翻译：高度包装的聚氨酯，硫酸和磷脂
公开(公告)号：US20090317908A1
公开(公告)日：2009-12-24
申请号：US12470285
申请日：2009-05-21
申请人： Alberto Haces , Valentina Ciccarone
发明人： Alberto Haces , Valentina Ciccarone
IPC分类号： C12N5/00 , C07C211/13 , C07C215/06
CPC分类号： C12N15/87 , A61K9/1272 , C07C211/63 , C07C217/40 , C07C233/36 , C07C381/12 , C07F9/5449 , C07F9/5463 , Y10S435/829
摘要： The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
摘要翻译：本发明公开了用于制备用于将大分子和其它化合物递送到细胞中的脂质聚集体的高填充聚阳离子铵，锍和鏻脂质化合物。它们对细胞的DNA依赖性转化特别有用。还公开了其制备和用作细胞内递送剂的方法。

2. 发明授权

US07501542B2 Highly-packed polycationic ammonium, sulfonium and phosphonium lipids 失效
标题翻译：高度包装的聚阳离子铵，锍和磷脂
公开(公告)号：US07501542B2
公开(公告)日：2009-03-10
申请号：US10762914
申请日：2004-01-21
申请人： Alberto Haces , Valentina C. Ciccarone
发明人： Alberto Haces , Valentina C. Ciccarone
IPC分类号： C07C233/36 , C07C211/62 , C07C291/00 , C07C213/00 , C07C211/00 , A61K31/04 , C07C225/00 , C07C321/00 , A01N33/12
CPC分类号： C12N15/87 , A61K9/1272 , C07C211/63 , C07C217/40 , C07C233/36 , C07C381/12 , C07F9/5449 , C07F9/5463 , Y10S435/829
摘要： The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
摘要翻译：本发明公开了用于制备用于将大分子和其它化合物递送到细胞中的脂质聚集体的高度堆积的聚阳离子铵，锍和鏻脂质化合物。它们对细胞的DNA依赖性转化特别有用。还公开了其制备和用作细胞内递送剂的方法。

3. 发明申请

US20080057550A1 Process for the Preparation of Amides 失效
标题翻译：酰胺的制备方法
公开(公告)号：US20080057550A1
公开(公告)日：2008-03-06
申请号：US11931719
申请日：2007-10-31
申请人： Karen Robins , Toru Nagasawa
发明人： Karen Robins , Toru Nagasawa
IPC分类号： C12P13/02
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitrites, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备亚硝酸盐的新型生物技术方法。该方法采用无菌纲，放线菌属或红球菌属的微生物。

4. 发明申请

US20080050798A1 Enzymes for the preparation of amides 失效
标题翻译：用于制备酰胺的酶
公开(公告)号：US20080050798A1
公开(公告)日：2008-02-28
申请号：US11931500
申请日：2007-10-31
申请人： Karen Robins , Toru Nagasawa
发明人： Karen Robins , Toru Nagasawa
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备腈的新型生物技术方法。该过程采用无菌纲，放线菌属或红球菌属的微生物。

5. 发明申请

US20070249034A1 Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals 有权
标题翻译：用于修复顽抗性有机物和重金属的表面活性剂生物催化剂
公开(公告)号：US20070249034A1
公开(公告)日：2007-10-25
申请号：US11810731
申请日：2007-06-07
申请人： Robin Brigmon , Sandra Story , Denis Altman , Christopher Berry
发明人： Robin Brigmon , Sandra Story , Denis Altman , Christopher Berry
IPC分类号： A62D3/02
CPC分类号： B09C1/10 , C12R1/01 , C12R1/05 , C12R1/40 , C12R1/41 , C12R1/425 , C12R1/44 , G21F9/18 , G21F9/28 , Y10S435/829 , Y10S435/874 , Y10S435/877 , Y10S435/878 , Y10S435/88 , Y10S435/882
摘要： Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with which PAHs may be degraded. Additionally, the biosurfactant also provides an additional ability to bind heavy metal ions for removal from a soil or aquatic environment.
摘要翻译：已经鉴定了具有分解和纯化的细菌的新菌株，其具有降解包括各种多环芳烃在内的石油烃的能力。几种分离物也表现出生产生物表面活性剂的能力。生物表面活性剂生产能力的组合以及降解PAHs的能力提高了多环芳烃降解的效率。此外，生物表面活性剂还提供了结合重金属离子以从土壤或水生环境中去除的附加能力。

6. 发明申请

US20070031949A1 Process for the preparation of amides 有权
标题翻译：酰胺的制备方法
公开(公告)号：US20070031949A1
公开(公告)日：2007-02-08
申请号：US11495035
申请日：2006-07-28
申请人： Karen Robins , Toru Nagasawa
发明人： Karen Robins , Toru Nagasawa
IPC分类号： C12P13/02 , C12N9/80 , C12N1/21
CPC分类号： C12N9/88 , C12N9/78 , C12P13/02 , C12R1/01 , C12R1/03 , Y10S435/822 , Y10S435/829
摘要： A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.
摘要翻译：描述了从酰胺开始制备腈的新型生物技术方法。该方法采用无菌纲，放线菌属或红球菌属的微生物。

7. 发明申请

US20050106702A1 Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals 有权
标题翻译：用于修复顽抗性有机物和重金属的表面活性剂生物催化剂
公开(公告)号：US20050106702A1
公开(公告)日：2005-05-19
申请号：US10712491
申请日：2003-11-13
申请人： Robin Brigmon , Sandra Story , Denis Altman , Christopher Berry
发明人： Robin Brigmon , Sandra Story , Denis Altman , Christopher Berry
IPC分类号： B09C1/10 , C01C1/00 , C12N1/20 , C12R1/01 , C12R1/05 , C12R1/40 , C12R1/41 , C12R1/425 , C12R1/44 , C12S1/00
CPC分类号： B09C1/10 , C12R1/01 , C12R1/05 , C12R1/40 , C12R1/41 , C12R1/425 , C12R1/44 , G21F9/18 , G21F9/28 , Y10S435/829 , Y10S435/874 , Y10S435/877 , Y10S435/878 , Y10S435/88 , Y10S435/882
摘要： Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with which PAHs may be degraded. Additionally, the biosurfactant also provides an additional ability to bind heavy metal ions for removal from a soil or aquatic environment.
摘要翻译：已经鉴定了具有分解和纯化的细菌的新菌株，其具有降解包括各种多环芳烃在内的石油烃的能力。几种分离物也表现出生产生物表面活性剂的能力。生物表面活性剂生产能力的组合以及降解PAHs的能力提高了多环芳烃降解的效率。此外，生物表面活性剂还提供了结合重金属离子以从土壤或水生环境中去除的附加能力。

8. 发明授权

US06762035B1 Method and test strips for the measurement of fat loss during weight loss programs 失效
标题翻译：减肥计划中测量脂肪损失的方法和测试条
公开(公告)号：US06762035B1
公开(公告)日：2004-07-13
申请号：US10067660
申请日：2002-02-04
申请人： Surendra K. Gupta
发明人： Surendra K. Gupta
IPC分类号： C12Q132
CPC分类号： G01N33/523 , C12Q1/32 , G01N2800/044 , Y10S435/829 , Y10S435/968 , Y10S435/97
摘要： A method for monitoring the progress of fat loss in a patient during a weight loss program which comprises, contacting a body fluid sample from said patient with a solid test strip to provide a color indication of the presence in said body fluid of &bgr;-hydroxybutyrate, optionally together with acetoacetate and/or acetone.
摘要翻译：一种用于在减肥计划期间监测患者的脂肪减少进展的方法，其包括：使来自所述患者的体液样品与固体测试条接触，以提供在β-羟基丁酸酯的所述体液中存在的颜色指示，任选地与乙酰乙酸酯和/或丙酮一起。

9. 发明授权

US06746526B1 Disazodyestuffs for ink jet printing 失效
标题翻译：用于喷墨打印的双组份
公开(公告)号：US06746526B1
公开(公告)日：2004-06-08
申请号：US10089174
申请日：2002-03-27
申请人： Prahalad Manibhai Mistry
发明人： Prahalad Manibhai Mistry
IPC分类号： C09D1102
CPC分类号： C09D11/328 , C09B31/08 , Y10S435/829 , Y10S435/836 , Y10T428/24802
摘要： 1. A compound of Formula (1) and salts thereof: wherein: A is a substituted phenyl group carrying a group of the formula —NR3R4 and an ortho group selected from sulpho, phosphonato and phosphinato; n is 0 or 1; L1 and L2 are each independently H, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl, or L1 and L2 together with the N atom to which they are attached form an optionally substituted 5- or 6-membered ring; R1 and R2 are each independently optionally substituted alkyl or optionally substituted alkoxy; and R3 and R4 are each independently H, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl, or R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted 5- or 6-membered ring; or R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted aryl and R4 is an acyl group. The use of these compounds in inks and the use of inks comprising these compounds in ink jet printing.
摘要翻译： 1.式（1）的化合物及其盐：其中：A是带有-NR 3 R 4基团的取代苯基和选自磺基，膦酸酯和膦酰基的正基; n是 0或1; L 1和L 2各自独立地为H，任选取代的烷基，任选取代的环烷基或任选取代的芳基，或L 1和L 2与它们所连接的N原子一起形成任选取代的5-或6-元环; R 1和R 2各自独立地是任选取代的烷基或任选取代的烷氧基; R 3和R 4各自独立地为H，任选取代的烷基，任选取代的环烷基或任选取代的芳基，或R 3和R 4与它们所连接的氮原子一起形成任选取代的 5-或6-元环; 或R 3为H，任选取代的烷基，任选取代的环烷基或任选取代的芳基，R 4为酰基。这些化合物在油墨中的应用以及在喷墨印刷中使用包含这些化合物的油墨。

10. 发明申请

US20030170874A1 Biodesulfurization of hydrocarbons 有权
标题翻译：碳氢化合物的生物脱硫
公开(公告)号：US20030170874A1
公开(公告)日：2003-09-11
申请号：US10372519
申请日：2003-02-24
发明人： Isora Ranson , Carmen M. Rivas
IPC分类号： C12N001/20
CPC分类号： C10G32/00 , C12N1/20 , C12P3/00 , Y10S435/829
摘要： A process for treating liquid hydrocarbon, includes the steps of providing a liquid hydrocarbon containing complex sulfur-containing compounds, providing a bioactive material selected from or derived from members of genus Alcaligenes; and exposing the liquid hydrocarbon to the bioactive material under effective conditions such that the bioactive material interacts with the complex sulfur compounds and transforms the organic sulfur-containing compounds into inorganic sulfur compounds.
摘要翻译：一种处理液态烃的方法，包括提供含有复合含硫化合物的液态烃，提供选自或源自产碱杆菌成员的生物活性物质的步骤; 并在有效条件下将液体烃暴露于生物活性物质，使得生物活性物质与复合硫化合物相互作用并将有机含硫化合物转化为无机硫化合物。

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