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1. 发明授权

US07906315B2 Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals 有权
公开(公告)号：US07906315B2
公开(公告)日：2011-03-15
申请号：US11810773
申请日：2007-06-07
申请人： Robin L. Brigmon , Sandra Story , Denis J. Altman , Christopher J. Berry
发明人： Robin L. Brigmon , Sandra Story , Denis J. Altman , Christopher J. Berry
IPC分类号： A62D3/00 , A62D3/02 , B09B3/00 , B09C1/10
CPC分类号： B09C1/10 , C12R1/01 , C12R1/05 , C12R1/40 , C12R1/41 , C12R1/425 , C12R1/44 , G21F9/18 , G21F9/28 , Y10S435/829 , Y10S435/874 , Y10S435/877 , Y10S435/878 , Y10S435/88 , Y10S435/882
摘要： Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with which PAHs may be degraded. Additionally, the biosurfactant also provides an additional ability to bind heavy metal ions for removal from a soil or aquatic environment.

2. 发明申请

US20090263874A1 L-GLUTAMIC ACID-PRODUCING BACTERIUM AND METHOD FOR PRODUCING L-GLUTAMIC ACID 有权
标题翻译： L-谷氨酸生产细菌和生产L-谷氨酸的方法
公开(公告)号：US20090263874A1
公开(公告)日：2009-10-22
申请号：US11624080
申请日：2007-01-17
申请人： Mika Moriya , Hiroshi Izui , Eiji Ono , Kazuhiko Matsui , Hisao Ito , Yoshihiko Hara
发明人： Mika Moriya , Hiroshi Izui , Eiji Ono , Kazuhiko Matsui , Hisao Ito , Yoshihiko Hara
IPC分类号： C12P13/14
CPC分类号： C12N9/0016 , C12N9/88 , C12P13/14 , C12R1/01 , C12R1/425 , Y10S435/822 , Y10S435/88
摘要： L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in an activity of an enzyme catalyzing a reaction branching from a pathway for L-glutamic acid biosynthesis and producing a compound other than L-glutamic acid, and collecting produced L-glutamic acid from the culture medium.
摘要翻译： L-谷氨酸通过在液体培养基中培养属于肠杆菌属或沙雷氏菌属的具有生产L-谷氨酸能力的微生物产生，其增加了催化L-谷氨酸生物合成的反应的酶的活性，或其催化从L-谷氨酸生物合成途径分支的反应的酶的活性降低或缺乏，并产生除L-谷氨酸以外的化合物，并从培养基中收集L-谷氨酸。

3. 发明申请

US20050271629A1 Means for biologically controlling cryptogamic plant diseases 失效
标题翻译：用于生物控制密码植物病害的手段
公开(公告)号：US20050271629A1
公开(公告)日：2005-12-08
申请号：US10520294
申请日：2003-07-01
申请人： Bernard Paul
发明人： Bernard Paul
IPC分类号： A01N63/04 , A01N63/00
CPC分类号： A01N63/04 , Y10S435/837 , Y10S435/838 , Y10S435/839 , Y10S435/874 , Y10S435/88 , Y10S435/938 , Y10S435/945 , A01N63/00 , A01N2300/00
摘要： The invention concerns the application of compositions of micro-organisms in biological control of vin crptogamic diseases. Said composition comprises a mixture of at least one bacterium and at least one yeast, the bacterium or bacteria and the yeast(s) being non-toxic for the plant. The invention also concerns bacterial and yeast strains, as well as biofungicide formulations containing an efficient amount of at least one composition of micro-organisms including in mixture at least one bacterium and one yeast, the bacterium or bacteria and the yeast(s) being non-toxic for the plant, and a composition of filamentous fungi, in particular of the genus Pichia, Pythium, Trichoderma, Gliocladium, Ampelomyces, Talaromyces, Epicococcum, combined with an inert carrier. The invention is useful for treating cryptogamic plant diseases, in particular crop plants and vine.
摘要翻译：本发明涉及微生物组合物在葡萄球菌病的生物学控制中的应用。所述组合物包含至少一种细菌和至少一种酵母，所述细菌或细菌和对植物无毒的酵母的混合物。本发明还涉及细菌和酵母菌株，以及含有有效量的至少一种微生物组合物的生物杀真菌剂，包括至少一种细菌和一种酵母混合物，细菌或细菌和酵母不是对于植物是有毒的，以及丝状真菌的组合物，特别是毕赤酵母属，腐霉属，木霉属，胶霉属，Ampelomyces，Talaromyces，Epicococcum，与惰性载体结合的组合物。本发明可用于治疗隐窝性植物病害，特别是作物植物和葡萄藤。

4. 发明授权

US06344347B1 Method for producing L-amino acids by fermentation 有权
标题翻译：通过发酵生产L-氨基酸的方法
公开(公告)号：US06344347B1
公开(公告)日：2002-02-05
申请号：US09663795
申请日：2000-09-18
申请人： Kuniki Kino , Tetsuya Abe
发明人： Kuniki Kino , Tetsuya Abe
IPC分类号： C12P1324
CPC分类号： C12P13/24 , C12P13/04 , C12R1/19 , Y10S435/83 , Y10S435/832 , Y10S435/839 , Y10S435/843 , Y10S435/849 , Y10S435/88 , Y10S435/881
摘要： The present invention provides an industrially efficient method for producing an L-amino acid useful as medicament, chemical agent, food material and feed additive, and the method comprising culturing in a medium a microorganism having an ability to produce the L-amino acid and having resistance to a DNA gyrase inhibitor or a microorganism having an ability to produce the L-amino acid and having both resistance to a DNA gyrase inhibitor and resistance to an aminoquinoline derivative, producing and accumulating the L-amino acid therein and recovering the L-amino acid therefrom.
摘要翻译：本发明提供了用于制备可用作药物，化学试剂，食品材料和饲料添加剂的L-氨基酸的工业上有效的方法，所述方法包括在培养基中培养具有产生L-氨基酸的能力的微生物，并具有对DNA促旋酶抑制剂或具有产生L-氨基酸的能力并对DNA促旋酶抑制剂具有抗性和对氨基喹啉衍生物具有抗性的微生物的抗性，其中产生和积累L-氨基酸并回收L-氨基酸酸。

5. 发明授权

US5922568A Gene participating in the mechanism of secretion of esterase 失效
标题翻译：基因参与酯酶分泌机制
公开(公告)号：US5922568A
公开(公告)日：1999-07-13
申请号：US5232
申请日：1998-01-09
申请人： Takeji Shibatani , Hiroyuki Akatsuka , Eri Kawai
发明人： Takeji Shibatani , Hiroyuki Akatsuka , Eri Kawai
IPC分类号： C12N9/16 , C12P21/06 , C07H21/04 , C12N1/20
CPC分类号： C12N9/16 , Y10S435/88
摘要： An isolated gene encoding a polypeptide which is required for secretion of esterase originated from a microorganism of the genus Serratia, a recombinant plasmid comprising a plasmid prepared by inserting the isolated gene into a vector plasmid, a microorganism transformed with the recombinant plasmid, and a method for the production of an esterase which comprises cultivating the transformant microorganism as set forth above in a medium and collecting the produced esterase outside and inside the cells. The transformed microorganism have remarkably excellent capability of extracellular secretion of esterase.
摘要翻译：编码分泌来源于沙雷氏菌属微生物的酯酶所需的多肽的分离基因，该重组质粒包含通过将分离的基因插入载体质粒而制备的质粒，用重组质粒转化的微生物，以及方法用于生产酯酶，其包括在培养基中培养如上所述的转化微生物并在细胞内外收集所产生的酯酶。转化的微生物具有非常优异的酯酶细胞外分泌能力。

6. 发明授权

US5436145A Process for preparing 6-hydroxy nitrogen-containing 6-membered ring compounds 失效
标题翻译：制备6-羟基含氮6元环化合物的方法
公开(公告)号：US5436145A
公开(公告)日：1995-07-25
申请号：US246570
申请日：1994-05-20
申请人： Mari Yasuda , Haruyuki Ohkishi , Katsutoshi Sato , Yuuki Morimoto , Toru Nagasawa
发明人： Mari Yasuda , Haruyuki Ohkishi , Katsutoshi Sato , Yuuki Morimoto , Toru Nagasawa
IPC分类号： C12P17/06 , C12P17/12 , C12R1/01 , C12R1/06
CPC分类号： C12P17/12 , Y10S435/822 , Y10S435/824 , Y10S435/84 , Y10S435/843 , Y10S435/847 , Y10S435/85 , Y10S435/859 , Y10S435/874 , Y10S435/876 , Y10S435/877 , Y10S435/88 , Y10S435/881
摘要： 6-Hydroxy nitrogen-containing 6-membered ring compounds of the following general formula (II): ##STR1## wherein R.sup.1 represents carboxy group, carbamoyl group, cyano group, formyl group, C.sub.1 -C.sub.5 hydroxyalkyl group, C.sub.2 -C.sub.6 alkoxycarbonyl group, carboxyvinyl group, carboxymethyl group or oxime group, R.sup.2 represents hydrogen atom or carboxy group, and A represents carbon atom or nitrogen atom, can be prepared by reacting a nitrogen-containing 6-membered ring compounds of the following general formula (I): ##STR2## wherein R.sup.1, R.sup.2 and A are as defined in the general formula (II) above, with a microorganism or physico-chemically treated microorganism in an aqueous medium. Efficiency of the above reaction can be raised by conducting the reaction in the presence of phenazine methosulfate.
摘要翻译：下述通式（II）的6-羟基含氮6元环化合物：其中R 1表示羧基，氨基甲酰基，氰基，甲酰基，C 1 -C 5羟基烷基，C 2 -C 6 烷氧基羰基，羧基乙烯基，羧甲基或肟基，R2表示氢原子或羧基，A表示碳原子或氮原子，可以通过使下述通式（I）的含氮6元环化合物）：其中R 1，R 2和A如上述通式（II）中所定义，其在水性介质中与微生物或物理化学处理的微生物一起使用。可以通过在吩嗪甲硫酸盐存在下进行反应来提高上述反应的效率。

7. 发明授权

US5418168A Biologically pure culture of the microorganism, streptomyces cyaneogriseus subspecies noncyanogenus, or a mutant thereof 失效
标题翻译：微生物的生物学纯培养物，非花青素链霉菌亚种，或其突变体
公开(公告)号：US5418168A
公开(公告)日：1995-05-23
申请号：US927581
申请日：1992-08-10
申请人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
发明人： Guy T. Carter , Margaret J. Torrey , Michael Greenstein
IPC分类号： A01N63/02 , C07H19/01 , C12P1/06 , C12N1/20 , C12P17/18
CPC分类号： C07H19/01 , A01N63/02 , C12P1/06 , Y10S435/88 , Y10S435/886
摘要： This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F28249.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.
摘要翻译：本发明涉及称为LL-F28249α，LL-F28249β，LL-F28249γ，LL-F28249Δ，LL-F28249ε，LL-F28249zeta，LL-F28249 eta，LL-F28249θ，LL-F28249 iota，LL-F28249 kappa，LL-F28249λ，LL-F28249 mu，LL-F28249nu和LL-F28249 omega，通过发酵生产，其从粗溶液中回收和浓缩的方法，以及其纯化方法以及其药学上和药理上可接受的盐。本发明在其范围内包括衍生自新发现和先前未培养的微生物Streptomyces cyaneogriseus subsp。的生物纯培养物。非花青素，NRRL 15773。

8. 发明授权

US5133962A Method of controlling coleopteran insects with Bacillus thuringiensis 失效
标题翻译：用苏云金芽孢杆菌控制鞘翅目昆虫的方法
公开(公告)号：US5133962A
公开(公告)日：1992-07-28
申请号：US434140
申请日：1989-11-09
申请人： August J. Sick , Thomas E. Gilroy
发明人： August J. Sick , Thomas E. Gilroy
IPC分类号： A61K38/00 , C07K14/325 , C12N1/21 , C12N15/32
CPC分类号： C07K14/325 , A61K38/00 , Y10S435/822 , Y10S435/823 , Y10S435/829 , Y10S435/831 , Y10S435/847 , Y10S435/874 , Y10S435/88 , Y10S435/911 , Y10S435/946
摘要： A novel B.t. toxin gene encoding a protein toxic to coleopteran insects has been cloned from a novel coleopteran-active B. thuringiensis microbe. The DNA encoding the B.t. toxin can be used to transform various prokaryotic and eukaryotic microbes to express the B.t. toxin. These recombinant microbes can be used to control coleopteran insects in various environments.
摘要翻译：小说B.t. 编码对鞘翅目昆虫有毒的蛋白质的毒素基因已经从新型鞘翅目昆虫活体苏云金芽孢杆菌微生物中克隆出来。编码B.t.的DNA 毒素可用于转化各种原核和真核微生物，以表达B.t. 毒素。这些重组微生物可用于控制各种环境中的鞘翅目昆虫。

9. 发明授权

US4071412A Ready made sterilized culture media and process of preparation 失效
标题翻译：准备灭菌的培养基和制备方法
公开(公告)号：US4071412A
公开(公告)日：1978-01-31
申请号：US574644
申请日：1975-05-05
申请人： Eli Eisenberg , Gideon Altmann , Bianca Bogokovsky , Mordechai Lapidot
发明人： Eli Eisenberg , Gideon Altmann , Bianca Bogokovsky , Mordechai Lapidot
IPC分类号： A61L2/08 , C12Q1/04 , C12K1/10
CPC分类号： A61L2/08 , C12M29/26 , C12M33/07 , C12Q1/04 , Y10S435/822 , Y10S435/849 , Y10S435/873 , Y10S435/875 , Y10S435/879 , Y10S435/88
摘要： A process for preparing sterile culture media in unit dosage form which comprises preparing a composition of such media of conventional composition, adjusted or augmented by adding constituents in such manner that after sterilization by ionizing radiation a sterile medium of satisfactory composition is obtained. Additional constituents added are radio protectors, increased quantities of indicators, enzymes preventing the formation of toxic degradation products, vitamins or a combination of any of these.
摘要翻译：一种以单位剂量形式制备无菌培养基的方法，其包括通过以下列方式加入成分来制备常规组合物的这种培养基的组合物：以通过电离辐射灭菌获得令人满意的组合物的无菌培养基的方式添加成分。添加的其他成分是无线电保护器，指标数量增加，防止毒性降解产物形成的酶，维生素或其中任何一种的组合。

10. 发明授权

US4057469A Process for the microbiological oxidation of steroids 失效
标题翻译：类固醇的微生物氧化过程
公开(公告)号：US4057469A
公开(公告)日：1977-11-08
申请号：US693685
申请日：1976-06-07
申请人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
发明人： Daikichiro Nishikawa , Yukio Imada , Masayuki Kinoshita , Katsuhiko Takahashi , Hajime Machida , Michitaro Nagasawa
IPC分类号： C07J1/00 , C12P33/00 , C07B29/02
CPC分类号： C12P33/00 , C07J1/0011 , C07J1/0022 , C12P33/005 , Y10S435/822 , Y10S435/83 , Y10S435/831 , Y10S435/84 , Y10S435/88
摘要： The improvement in a process for the production of 17-hydroxyandrosta-1,4-dien-3-one and androsta-1,4-diene-3,17-dione by the microbiological oxidation of a sterol, its 4-en-3-one derivative or its 1,4-dien-3-one derivative, which comprises adding to the culture medium at least one glyceride-containing substance selected from the group consisting of glycerides, fats, oil seeds and oil fruits in an amount sufficient that the culture medium contains at least 0.3 percent by weight of glycerides.
摘要翻译：通过固醇微生物氧化制备17-羟基雄甾-1,4-二烯-3-酮和雄甾-1,4-二烯-3,17-二酮的方法的改进，其4-烯-3 - 酮衍生物或其1,4-二烯-3-酮衍生物，其包括向培养基中加入至少一种选自甘油酯，脂肪，油籽和油果的含甘油酯的物质，其量足以使得培养基含有至少0.3重量％的甘油酯。

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