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1. 发明申请

US20170299567A1 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 审中-公开
公开(公告)号：US20170299567A1
公开(公告)日：2017-10-19
申请号：US15635988
申请日：2017-06-28
申请人： TearScience, Inc.
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： G01N33/22 , A61F9/007 , A61H7/00 , A61H9/00 , A61H23/02 , A61N1/40 , A61B18/04 , A61N7/00 , A61B18/12 , A61B5/00 , A61F7/00 , A61H39/08 , A61H15/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.

2. 发明授权

US09719977B2 Methods and systems for treating meibomian gland dysfunction using radio-frequency energy 有权
公开(公告)号：US09719977B2
公开(公告)日：2017-08-01
申请号：US13590828
申请日：2012-08-21
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： A61F7/08 , A61F9/00 , G01N33/22 , A61N1/40 , A61F9/007 , A61H7/00 , A61H9/00 , A61H23/02 , A61B5/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H39/08 , A61H15/00 , A61N7/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.

3. 发明授权

US09494527B2 Optical reader optic cleaning systems having motion deployed cleaning elements 有权
标题翻译：具有运动部署清洁元件的光学读取器光学清洁系统
公开(公告)号：US09494527B2
公开(公告)日：2016-11-15
申请号：US13713864
申请日：2012-12-13
申请人： Step Ahead Innovations, Inc.
发明人： James E. Clark
IPC分类号： G01N21/15 , G01N21/88 , G01N21/77 , C02F1/00 , G01N33/18 , G01N21/85 , F21V8/00 , G01N21/78 , G01N31/22 , A01K63/04 , G01N21/64
CPC分类号： G01N21/77 , A01K63/04 , C02F1/008 , C02F2103/42 , C02F2209/005 , C02F2209/006 , C02F2209/008 , C02F2209/06 , C02F2209/14 , C02F2209/15 , C02F2209/18 , G01N21/15 , G01N21/6428 , G01N21/78 , G01N21/8507 , G01N21/88 , G01N31/22 , G01N33/18 , G01N2021/758 , G01N2021/7786 , G01N2021/7793 , G01N2201/127 , G02B6/0001 , Y10S436/805 , Y10S436/809 , Y10T436/11 , Y10T436/115831 , Y10T436/12 , Y10T436/173076 , Y10T436/173845 , Y10T436/174614 , Y10T436/175383 , Y10T436/193333 , Y10T436/207497 , Y10T436/25 , Y10T436/25375
摘要： Cleaning systems for optics of optical readers to periodically clean one or more surfaces of the optics of matter that may deposit on surface(s) and that might interfere with the performance of the reader. In an example, the cleaning system is used on a chemical indicator apparatus that includes one or more chemical indicators that are read by an optical reader having an optic. During use, the chemical indicator apparatus is moved relative optic during a reading mode. A cleaning element is engaged with the chemical indicator apparatus so as to have a neutral position in which it cannot contact the optic during the reading mode. When it is desired to clean the optic, the chemical indicator apparatus is moved in a manner that causes the cleaning element to move from the neutral position to a deployed position in which it contacts the optic in a manner that cleans the optic as the apparatus continues to be moved.
摘要翻译：用于光学读取器的光学系统的清洁系统周期性地清洁可能沉积在表面上并且可能干扰读取器的性能的物质光学元件的一个或多个表面。在一个示例中，清洁系统用于化学指示器装置，其包括由具有光学元件的光学读取器读取的一个或多个化学指示器。在使用期间，在读取模式期间，化学指示器装置相对于光学元件移动。清洁元件与化学指示器装置接合，以便具有在读取模式期间其不能接触光学元件的中性位置。当需要清洁光学元件时，化学指示器装置以使得清洁元件从中立位置移动到展开位置的方式移动，在该展开位置中，该化学指示器装置以与装置相连的方式清洁光学元件的方式移动被移动

4. 发明授权

US09448219B2 Electro-mechanical switches and methods of use thereof 有权
公开(公告)号：US09448219B2
公开(公告)日：2016-09-20
申请号：US13893699
申请日：2013-05-14
申请人： William Jay Arora , Karen K. Gleason , George Barbastathis , Wyatt E. Tenhaeff
发明人： William Jay Arora , Karen K. Gleason , George Barbastathis , Wyatt E. Tenhaeff
IPC分类号： G01N27/04 , G01N33/00 , G01N27/12
CPC分类号： G01N33/0057 , G01N27/128 , Y10T436/147777 , Y10T436/163333 , Y10T436/173076 , Y10T436/173845
摘要： One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.

5. 发明授权

US09260740B2 Micro-organism test apparatus and methods of using the same 有权
标题翻译：微生物试验装置及其使用方法
公开(公告)号：US09260740B2
公开(公告)日：2016-02-16
申请号：US11922785
申请日：2005-06-23
申请人： Rosemary Katherine Cameron Sharpin
发明人： Rosemary Katherine Cameron Sharpin
IPC分类号： C12Q1/08 , C12Q1/04 , C12M1/00 , C12M1/34
CPC分类号： C12Q1/08 , C12M23/34 , C12M41/36 , C12Q1/04 , Y10T436/173076
摘要： The contamination of foodstuffs, additives, cosmetics, pharmaceuticals and the like by undesirable micro-organisms is threat to public health. On occasion, the level of bacteria that conventional testing techniques are designed to look for is so low that the test result for the bacterium is “negative”. However, the bacterium although present in un-detectably small amounts may multiply under the right conditions and given the shelf life of the product, may be able to recover to an extent whereby public health is threatened. This problem is alleviated by the provision of micro-organism testing apparatus comprising (a) an incubator, and (b) a multi-compartment resealable container provided with or adapted to receive a growth medium in one compartment and having a growth medium additive in another compartment, the compartments being separated by a barrier whose removal or puncture will expose the medium to the additive.
摘要翻译：不良微生物对食品，添加剂，化妆品，药品等的污染对公众健康构成威胁。有时，传统测试技术设计的细菌水平很低，使得细菌的检测结果为“阴性”。然而，细菌虽然以不可检测的少量存在，但可以在合适的条件下繁殖并给予产品的保存期限，可以恢复到公共卫生受到威胁的程度。通过提供微生物测试装置来减轻这个问题，微生物测试装置包括（a）培养箱和（b）多室可重新密封的容器，其提供或适于在一个隔室中接收生长培养基并且在另一个隔室中具有生长培养基添加剂隔间，隔室被隔离物隔开，其移除或穿刺将介质暴露于添加剂。

6. 发明申请

US20150362474A1 FUNCTIONALIZED NANOSTRUCTURES FOR DETECTING NITRO-CONTAINING COMPOUNDS 有权
标题翻译：用于检测含有硝基化合物的功能性纳米结构
公开(公告)号：US20150362474A1
公开(公告)日：2015-12-17
申请号：US14735146
申请日：2015-06-10
申请人： Tracense Systems Ltd.
发明人： Fernando PATOLSKY , Yoni ENGEL , Roey ELNATHAN
IPC分类号： G01N33/22
CPC分类号： G01N33/0057 , G01N27/00 , G01N27/4146 , G01N33/227 , Y10T436/17 , Y10T436/173076
摘要： Devices, methods and systems for detecting nitro-containing compounds such as TNT, which utilize semiconductor nanostructures modified by a functional moiety that interacts with the nitro-containing compound, are disclosed. The functional moiety is attached to the nanostructures and is being such that upon contacting a sample that contains the nitro-containing compound, the nanostructure exhibits a detectable change in an electrical property, which is indicative of the presence and/or amount of the nitro-containing compound in the sample. Electronic noses for generating recognition patterns of various nitro-containing compounds, made of a plurality of nanostructures modified by versatile functional moieties are also disclosed. The devices, methods and systems are suitable for detecting nitro-containing compounds in both liquid and gaseous states and for detecting a concentration of a nitro-containing compound such as TNT as low as attomolar concentrations.
摘要翻译：公开了用于检测含氮化合物如TNT的装置，方法和系统，其利用由与含硝基化合物相互作用的功能部分修饰的半导体纳米结构。功能部分连接到纳米结构上，并且使得当接触含有含硝基化合物的样品时，纳米结构显示出电性能的可检测变化，其表示硝基的化合物的存在和/或量，样品中含有的化合物。还公开了用于产生由通用功能部分修饰的多个纳米结构制成的各种含硝基化合物的识别图案的电子鼻。装置，方法和系统适用于检测液态和气态两者中的含硝基化合物，并且用于检测含氮化合物如TNT的浓度低至极限浓度。

7. 发明申请

US20150285736A1 METHOD AND ANALYZER FOR DETERMINING A MEASURED VALUE OF A MEASURED VARIABLE OF PROCESS AUTOMATION TECHNOLOGY 有权
标题翻译：用于确定测量过程自动化技术变量的测量值的方法和分析仪
公开(公告)号：US20150285736A1
公开(公告)日：2015-10-08
申请号：US14680574
申请日：2015-04-07
申请人： Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG
发明人： Edin Andelic , Ralf Bernhard , Michael Littmann
IPC分类号： G01N21/31 , G01N21/63 , G01N33/00 , G01N21/78
CPC分类号： G01N21/31 , G01N21/274 , G01N21/314 , G01N21/63 , G01N21/78 , G01N21/783 , G01N33/0036 , G01N2201/062 , G01N2201/129 , Y10T436/16 , Y10T436/173076 , Y10T436/173845
摘要： A method and analyzer for determining a measured value of a measured variable of process automation technology in a liquid or gaseous medium by means of an optical sensor, which has at least one emitter for sending light of at least two wavelengths, and a receiver associated with the emitter for receiving of received light, comprising the steps as follows: taking a sample of the medium; mixing the sample with one or more reagents; supplying the emitter with an exciter signal for producing the sent light, wherein the sent light by interaction with, especially by absorption by, the mixed sample is converted into received light as a function of the measured variable; producing a receiver signal by means of the receiver from the converted, received light; and determining the measured value based on the receiver signal and a calibration function. The method is characterized in that, in determining the measured value, aging of the reagents is taken into consideration, especially the calibration function includes a term which takes aging of the reagents into consideration.
摘要翻译：一种用于通过具有至少一个用于发送至少两个波长的光的发射器的光学传感器来确定液体或气体介质中的过程自动化技术的测量变量的测量值的方法和分析器，以及与至少两个波长的发射器相关联的接收器用于接收光的发射器，包括以下步骤：取介质的样品; 将样品与一种或多种试剂混合; 向发射器提供用于产生发射光的激发器信号，其中通过与混合样品的相互作用特别是通过吸收的发射光作为测量变量的函数被转换成接收光; 通过接收机从转换的接收光产生接收机信号; 以及基于接收机信号和校准功能确定测量值。该方法的特征在于，在确定测量值时考虑试剂的老化，特别是校准功能包括考虑试剂老化的术语。

8. 发明申请

US20150268215A1 PERSONAL SUBSTANCE DETECTION FIELD TEST KIT 有权
标题翻译：个人物质检测现场测试包
公开(公告)号：US20150268215A1
公开(公告)日：2015-09-24
申请号：US13748037
申请日：2013-01-23
申请人： Lindon Group, Inc.
发明人： Dalita Tomellini , Melinda Penney , Phil Brooks
IPC分类号： G01N33/22 , B65D43/22 , B65D43/16 , G01N21/78
CPC分类号： G01N33/227 , A45C13/02 , A45C13/1084 , G01N21/78 , G01N21/8483 , G01N2201/0221 , G01N2201/0222 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/163333 , Y10T436/170769 , Y10T436/171538 , Y10T436/173076 , Y10T436/173845
摘要： A personal-sized, portable explosive detection field test kit (ETK) and related methods of use. Embodiments of the disclosed ETK include a case having a closing system featuring three levels of closure which retain the case cover securely in a closed position until ready for use, while being easily opened when necessary. The ETK instructions are permanently attached to the case to prevent loss. The case includes retention features which retain the kit components until needed and protects them against loss or damage. The ETK includes one or more test tubes that are color coded and include abbreviated instructions.
摘要翻译：个人尺寸便携式爆炸物检测现场测试套件（ETK）及相关使用方法。所公开的ETK的实施例包括具有封闭系统的壳体，该封闭系统具有三级闭合，其将壳体盖牢固地保持在关闭位置，直到准备使用，同时在必要时容易打开。 ETK说明书永久附在案件上以防止损失。这种情况包括保留功能，保留套件组件直到需要，并保护它们免受损失或损坏。 ETK包括一个或多个颜色编码的试管，并包括缩写说明。

9. 发明申请

US20150253245A1 FLUORESCENT POLYMERS OF 7-HYDROXYCOUMARIN COMPOUNDS, CHEMICAL SENSORS COMPRISING THEM, AND POLYMERIZABLE FLUORESCENT COMPOUND OF 7-HYDROXYCOUMARIN 审中-公开
标题翻译： 7-羟基喹啉化合物的荧光聚合物，包含它们的化学传感器和7-羟基喹啉的可聚合荧光化合物
公开(公告)号：US20150253245A1
公开(公告)日：2015-09-10
申请号：US14622281
申请日：2015-02-13
申请人： Commissariat a l'énergie atomique et aux énergies alternatives
发明人： Pierrick Buvat , Lucie Malosse , Alain Siove , Dominique Ades
IPC分类号： G01N21/64 , G01N33/00 , C08F220/68
CPC分类号： G01N21/64 , C08F220/68 , C09B57/02 , C09B69/109 , G01N33/0037 , G01N33/0047 , G01N33/0057 , G01N33/52 , G01N2201/06113 , G01N2201/068 , Y02A50/245 , Y10T428/2982 , Y10T436/163333 , Y10T436/173076
摘要： A polymer is obtained by polymerization of a polymerizable fluorescent monomer compound of 7-hydroxycoumarin having the following formula (I): G is a substituent including a polymerizable chemical group R, and optionally of at least one other polymerizable monomer. The polymer can be used as a sensitive material in an optical sensor.
摘要翻译：通过聚合具有下式（I）的7-羟基香豆素的可聚合荧光单体化合物获得聚合物：G是包含可聚合化学基团R的取代基和任选的至少一种其它可聚合单体。聚合物可以用作光学传感器中的敏感材料。

10. 发明授权

US09116146B2 Quantitative and self-calibrating chemical analysis using paper-based microfluidic systems 有权
标题翻译：使用纸基微流体系统的定量和自校准化学分析
公开(公告)号：US09116146B2
公开(公告)日：2015-08-25
申请号：US13380303
申请日：2010-06-30
申请人： Wei Shen , Xu Li , Junfei Tian , Gil Garnier
发明人： Wei Shen , Xu Li , Junfei Tian , Gil Garnier
IPC分类号： B01L3/00 , G01N33/52 , G01N33/543 , G01N21/93 , G01N21/78 , G01N33/53 , G01N33/558
CPC分类号： G01N33/52 , B01L3/50273 , B01L2300/0816 , B01L2300/0864 , B01L2300/126 , B01L2400/0406 , G01N21/78 , G01N21/93 , G01N33/5302 , G01N33/543 , G01N33/54366 , G01N33/54386 , G01N33/558 , Y10T436/148888 , Y10T436/173076
摘要： A method of determining the concentration of a test fluid sample using a paper-based microfluidic system having a plurality of hydrophilic testing zones, including: a) depositing said test fluid sample on at least one said testing zone; b) depositing a plurality of standard fluid samples or reactives of differing known concentrations on other said testing zones; c) introducing an indicator solution to each said test zone to thereby react with the deposited fluid sample and result in a color intensity change which is a function of the fluid sample concentration; and d) comparing the differences in color intensity between the test fluid sample and the standard fluid samples or reactives to thereby determine the concentration of said test fluid sample.
摘要翻译：一种使用具有多个亲水测试区域的基于纸的微流体系统确定测试流体样品的浓度的方法，包括：a）将所述测试流体样品沉积在至少一个所述测试区域上; b）在其他所述测试区域上沉积不同已知浓度的多个标准流体样品或反应物; c）向每个所述测试区域引入指示剂溶液，从而与沉积的流体样品反应并导致作为流体样品浓度的函数的颜色强度变化; 以及d）比较测试流体样品和标准流体样品或反应物之间的颜色强度的差异，从而确定所述测试流体样品的浓度。

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