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1. 发明申请

WO2004063346A3 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063346A3
公开(公告)日：2004-11-25
申请号：PCT/US2004000501
申请日：2004-01-08
申请人： UNIV CALIFORNIA , MURRAY JAMES D , ANDERSON GARY B , MAGA ELIZABETH A
发明人： MURRAY JAMES D , ANDERSON GARY B , MAGA ELIZABETH A
IPC分类号： A01K67/027 , A23C19/00 , C12N20060101 , C12N5/00 , C12N9/36 , C12N15/85 , C12P21/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2267/02 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了包含编码溶菌酶的转基因的转基因有蹄类动物，以及用于生产这种动物的方法。本发明进一步提供了使用主题转基因有蹄类动物以及从主题转基因有蹄类动物收获的食品产生食品，例如牛奶或奶制品的方法。

2. 发明申请

WO2004063346A2 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063346A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000501
申请日：2004-01-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
发明人： MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
IPC分类号： C12N
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2267/02 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了包含编码溶菌酶的转基因的转基因有蹄类动物，以及用于生产这种动物的方法。本发明还提供了使用受试者转基因有蹄类动物以及从受试者转基因有蹄类型收获的食品来生产食品如牛奶或奶制品的方法。

3. 发明申请

WO2004063349A2 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063349A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000606
申请日：2004-01-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
发明人： MURRAY, James, D. , ANDERSON, Gary, B. , MAGA, Elizabeth, A.
IPC分类号： C12N
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2227/102 , A01K2267/02 , C07K14/4717 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and further has an attenuated or non-functional β-lactoglobulin allele. The invention further provides methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了转基因有蹄类动物，其包括编码溶菌酶的转基因，并且还具有减毒或无功能的β-乳球蛋白等位基因。本发明还提供了用于生产这种动物的方法。本发明进一步提供了使用主题转基因有蹄类动物以及从主题转基因有蹄类动物收获的食物产品生产食物产品例如牛奶或奶产品的方法。

4. 发明申请

WO2003022220A2 METHOD OF GENERATING A TRANSGENIC LIVESTOCK ANIMAL 审中-公开
标题翻译：产生转基因动物的方法
公开(公告)号：WO2003022220A2
公开(公告)日：2003-03-20
申请号：PCT/US2002/028763
申请日：2002-09-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MAGA, Elizabeth, A. , ANDERSON, Gary, B. , MURRAY, James, D. , OPPENHEIM, Stefanie, M.
发明人： MAGA, Elizabeth, A. , ANDERSON, Gary, B. , MURRAY, James, D. , OPPENHEIM, Stefanie, M.
IPC分类号： A61K
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2227/108 , C12N15/8509 , C12N15/87 , C12N15/873
摘要： The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or pluripotent cell and then growing the recombinant totipotent or pluripotent cell to produce the transgenic livestock animal. The invention further provides kits for use in generating transgenic non-human animals of the invention.
摘要翻译：本发明提供了生产转基因家畜的方法。方法通常包括首先将由核酸和重组酶组成的核蛋白引入全能或多能细胞以产生重组全能或多能细胞，然后生长重组全能或多能细胞以产生转基因家畜。本发明还提供用于产生本发明的转基因非人动物的试剂盒。

5. 发明申请

WO1997013353A1 COMMUNICATION SYSTEM AND METHOD 审中-公开
标题翻译：通信系统和方法
公开(公告)号：WO1997013353A1
公开(公告)日：1997-04-10
申请号：PCT/US1996015190
申请日：1996-09-20
申请人： OMNIPOINT CORPORATION , ANDERSON, Gary, B. , GAVETTE, Sherman , HETHERINGTON, William, D. , LINDSAY, Charles, L. , JENSEN, Ryan, N.
发明人： OMNIPOINT CORPORATION
IPC分类号： H04M11/00
CPC分类号： H04L49/901 , G10L19/012 , H04B7/0805 , H04B7/10 , H04B7/2618 , H04B7/2668 , H04L1/0002 , H04L1/0025 , H04L1/1838 , H04L1/20 , H04L47/50 , H04L47/522 , H04L47/6215 , H04L49/90 , H04W36/18 , H04W52/04 , H04W52/08 , H04W52/24 , H04W52/36 , H04W52/362 , H04W52/367 , H04W52/40 , H04W68/00 , H04W72/1278
摘要： A mobile communication system (101) having a layered architecture (401) communicates user and signaling data (1105) among components of the communication system in the form of information elements which are encapsulated within packets (1005) which may be passed across one or more system interfaces (1401). The mobile communication system comprises mobile user stations (102), base stations (104), and base station controllers (105) and operates as a transparent data pipeline between application end users, such as a telephone service (126), connected at base station controllers (105) and mobile user stations (102). In a particular embodiment, the interface between the base station (104) and the user stations (102) is a TDMA interface, and signaling traffic between the base station (104) and each of the user stations (102) is conducted in either a fast control traffic mode or a slow control traffic mode. In the fast control traffic mode, signaling messages are exchanged between the base station (104) and a user station (102) in a plurality of time slots (302) within a timespan of a single time frame (301); in the slow control traffic mode, signaling messages are exchanged between the base station (104) and a user station (102) in no more than a single time slot (302) within a timespan of a single time frame (301).
摘要翻译：具有分层体系结构（401）的移动通信系统（101）以封装在分组（1005）内的信息元素的形式在通信系统的组件之间传送用户和信令数据（1105），所述信息元素可以跨过一个或多个系统接口（1401）。移动通信系统包括移动用户站（102），基站（104）和基站控制器（105），并且作为在基站之间连接的诸如电话业务（126）的应用终端用户之间的透明数据流控制器（105）和移动用户站（102）。在特定实施例中，基站（104）和用户站（102）之间的接口是TDMA接口，并且基站（104）和每个用户站（102）之间的信令业务在快速控制流量模式或慢速控制流量模式。在快速控制业务模式中，在单个时间帧（301）的时间段内的多个时隙（302）中的基站（104）和用户站（102）之间交换信令消息; 在慢速控制业务模式中，信令消息在单个时间帧（301）的时间段内在不超过一个时隙（302）的基站（104）和用户站（102）之间进行交换。

6. 发明申请

WO2004063349A3 LYSOZYME TRANSGENIC UNGULATES 审中-公开
公开(公告)号：WO2004063349A3
公开(公告)日：2004-11-11
申请号：PCT/US2004000606
申请日：2004-01-08
申请人： UNIV CALIFORNIA , MURRAY JAMES D , ANDERSON GARY B , MAGA ELIZABETH A
发明人： MURRAY JAMES D , ANDERSON GARY B , MAGA ELIZABETH A
IPC分类号： A01K67/027 , C07K14/47 , C12N20060101 , C12N9/36 , C12N15/85 , G01N33/06
CPC分类号： A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2227/102 , A01K2267/02 , C07K14/4717 , C12N9/2462 , C12N15/8509
摘要： The present invention provides transgenic ungulates that include a transgene that encodes lysozyme, and further has an attenuated or non-functional beta-lactoglobulin allele. The invention further provides methods for producing such animals. The invention further provides methods of producing a food product, such as milk, or a milk product, using a subject transgenic ungulate, as well as food products harvested from a subject transgenic ungulate.
摘要翻译：本发明提供了包含编码溶菌酶的转基因并且还具有减毒或非功能性β-乳球蛋白等位基因的转基因有蹄类动物。本发明还提供了用于生产这种动物的方法。本发明还提供了使用受试者转基因有蹄类动物以及从受试者转基因有蹄类型收获的食品来生产食品如牛奶或奶制品的方法。

7. 发明申请

WO03022220A3 METHOD OF GENERATING A TRANSGENIC LIVESTOCK ANIMAL 审中-公开
标题翻译：产生转基因动物的方法
公开(公告)号：WO03022220A3
公开(公告)日：2003-07-03
申请号：PCT/US0228763
申请日：2002-09-06
申请人： UNIV CALIFORNIA , MAGA ELIZABETH A , ANDERSON GARY B , MURRAY JAMES D , OPPENHEIM STEFANIE M
发明人： MAGA ELIZABETH A , ANDERSON GARY B , MURRAY JAMES D , OPPENHEIM STEFANIE M
IPC分类号： A01K67/027 , C12N15/85 , C12N15/87 , C12N15/873 , A01K67/00 , C12N9/14 , C12N15/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2227/108 , C12N15/8509 , C12N15/87 , C12N15/873
摘要： The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or pluripotent cell and then growing the recombinant totipotent or pluripotent cell to produce the transgenic livestock animal. The invention further provides kits for use in generating transgenic non-human animals of the invention.
摘要翻译：本发明提供了生产转基因家畜的方法。所述方法通常涉及首先将由核酸和重组酶组成的核蛋白引入全能或多能细胞中以产生重组全能或多能细胞，然后使重组全能或多能细胞生长以产生转基因家畜动物。本发明进一步提供用于产生本发明的转基因非人动物的试剂盒。

8. 发明申请

WO1997025412A1 UNGULATE EMBRYONIC STEM-LIKE CELLS, METHODS OF MAKING AND USING THE CELLS TO PRODUCE TRANSGENIC UNGULATES 审中-公开
标题翻译：单核细胞干细胞样细胞，制备和使用细胞生产转基因细胞的方法
公开(公告)号：WO1997025412A1
公开(公告)日：1997-07-17
申请号：PCT/US1997000041
申请日：1997-01-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ANDERSON, Gary, B. , SHIM, Hosup
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
IPC分类号： C12N05/00
CPC分类号： C12N15/8778 , A01K67/0271 , C12N5/0611
摘要： Primordial germ cells are extracted from post blastocyst embryos of an ungulate such as extracting primordial germ cells from the gonadal ridges of 25-day porcine embryos or 34-40 day bovine embryos. The primordial germ cells are cultured in long term culture (over 30 days) resulting in cells which resemble embryonic stem cells in morphology and with respect to maintaining pluripotency. The cells obtained can be maintained for several months in culture and can be genetically manipulated using homologous recombination technology in order to insert desired genetic material into the genetic compliment of the cell at a desired location. The genetically manipulated cell can be inserted into a blastocyst obtained from the same species of animal as the cell was derived in order to produce a chimeric ungulate which ungulate may, via its genetic engineering, produce desired pharmaceutical products.
摘要翻译：原始生殖细胞从有蹄类动物的胚泡胚胎中提取，例如从25天猪胚胎或34-40天牛胚胎的性腺中提取原始生殖细胞。原始生殖细胞在长期培养（30天以上）中培养，导致类似胚胎干细胞形态和保持多能性的细胞。获得的细胞可以在培养物中维持数月，并且可以使用同源重组技术进行遗传操作，以便将期望的遗传物质插入到所需位置的细胞的遗传补体中。遗传操纵的细胞可以插入从与细胞衍生的相同动物种类获得的囊胚中，以便产生嵌合的有蹄类动物，其可以通过其遗传工程产生所需的药物产品。

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