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1. 发明授权

US08916827B2 Device and system for selectively detecting gas components or concentrations of gas components in gas to be analyzed and method for operating such device 有权
标题翻译：用于选择性地检测要分析的气体中的气体组分或气体组分的浓度的装置和系统以及用于操作该装置的方法
公开(公告)号：US08916827B2
公开(公告)日：2014-12-23
申请号：US13817413
申请日：2011-08-11
申请人： Alexander Frey , Harry Hedler , Philip Clissold Howell
发明人： Alexander Frey , Harry Hedler , Philip Clissold Howell
IPC分类号： G01N21/00 , G01N33/00 , B82Y20/00 , G02B6/122 , G01J3/10 , G01N21/35 , G01N21/77 , G01N21/03
CPC分类号： G01N33/0027 , B82Y20/00 , G01J3/108 , G01N21/0303 , G01N21/3504 , G01N21/774 , G01N21/7746 , G02B6/1225
摘要： A photonic crystal, which is a periodically arranged structure made of free-standing columns, has a base material of at least one metal or a metal alloy. Intermediate spaces between the columns allow passage of a gas to be analyzed. The photonic crystal has predefined imperfections, by which at least one resonator is formed, the resonant frequency of which is in a frequency range which is absorbed by a gas component to be detected. A heating unit heats at least some of the columns and at least one detector element extracts the energy present in the resonator in the heated state under the action of the gas to be analyzed. The device may have extremely small dimensions and very low energy consumption.
摘要翻译：作为由独立柱构成的周期性排列的结构的光子晶体具有至少一种金属或金属合金的基材。列之间的中间空间允许待分析的气体通过。光子晶体具有预定义的缺陷，由此形成至少一个谐振器，其谐振频率处于被待检测的气体成分吸收的频率范围内。加热单元加热至少一些列，并且至少一个检测器元件在待分析气体的作用下以加热状态提取谐振器中存在的能量。该装置可能具有非常小的尺寸和非常低的能量消耗。

2. 发明授权

US08702921B2 Biosensors array and method for operating a biosensor array 有权
标题翻译：用于操作生物传感器阵列的生物传感器阵列和方法
公开(公告)号：US08702921B2
公开(公告)日：2014-04-22
申请号：US11019948
申请日：2004-12-21
申请人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Franz Hofmann , Birgit Holzapfl , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N27/26
CPC分类号： G01N27/3276
摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.
摘要翻译：一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘从所述至少一个检测线。在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条，至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元，将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

3. 发明授权

US08480877B2 Sensor arrangement comprising an electrode for detecting diffused loaded particles 有权
公开(公告)号：US08480877B2
公开(公告)日：2013-07-09
申请号：US11597296
申请日：2005-05-24
申请人： Alexander Frey , Franz Hofmann
发明人： Alexander Frey , Franz Hofmann
IPC分类号： G01N27/327 , G01N27/416
CPC分类号： G01N33/5438 , C12Q1/6825 , G01N27/3277
摘要： A sensor arrangement for detecting particles potentially contained in an analyte is disclosed. The arrangement includes a substrate; at least one sensor electrode which is arranged on and/or in the substrate and on which scavenger molecules, which hybridize with particles that are potentially contained in an analyte and are to be detected, are immobilized, electrically charged particles generated by hybridization being detectable on the at least one sensor electrode; and at least one diffusion detection electrode which is arranged in a surrounding region of the at least one sensor electrode and is embodied in such a way that it detects electrically charged particles that are generated by hybridization and can be diffused away by the at least one sensor electrode.

4. 发明授权

US08330803B2 Method and apparatus for 3D digitization of an object 有权
标题翻译：一种物体的3D数字化方法和装置
公开(公告)号：US08330803B2
公开(公告)日：2012-12-11
申请号：US12459640
申请日：2009-07-06
申请人： Alexander Frey , Daniel Kreutzer , Thomas Mayer , Marcus Steinbichler
发明人： Alexander Frey , Daniel Kreutzer , Thomas Mayer , Marcus Steinbichler
IPC分类号： H04N13/02
CPC分类号： G01B11/25 , G01B2210/52 , G06T7/593 , G06T2207/10012
摘要： In a method for 3D digitization of an object (1), a plurality of camera images of the object are recorded and assembled to determine the 3D coordinates of the object. To improve such method, pictures are taken from the object (1), from which 2D feature points (11, 12, 13; 21, 22, 23) of the object (1) are determined. The 3D coordinates of the 2D feature points are determined. The 2D point correspondences (32, 32, 22) between the 2D feature points of a picture and the 2D feature points of another picture are determined. Several of these 2D point correspondences are selected, and an associated 3D transformation is determined. The quality of this 3D transformation is determined with reference to the transformed 3D coordinates of the 2D feature points. Valid 3D feature points are determined therefrom. For assembling the camera images of the object (1), the 3D coordinates of the valid 3D feature points are used.
摘要翻译：在用于对象（1）的3D数字化的方法中，记录和组合对象的多个相机图像以确定对象的3D坐标。为了改善这种方法，从物体（1）取出图像，从物体（1）的2D特征点（11,12,13,21,23,23）确定。确定2D特征点的3D坐标。确定图像的2D特征点与另一图像的2D特征点之间的2D点对应（32,32,22）。选择这些2D点对应中的几个，并且确定相关联的3D变换。参考2D特征点的变换3D坐标来确定该3D变换的质量。确定有效的3D特征点。为了组装对象（1）的相机图像，使用有效3D特征点的3D坐标。

5. 发明申请

US20120252055A1 ARRANGEMENT AND METHOD USING MICROSENSORS FOR MEASURING CELL VITALITIES 有权
标题翻译：使用微型传感器测量细胞毒素的装置和方法
公开(公告)号：US20120252055A1
公开(公告)日：2012-10-04
申请号：US13499376
申请日：2010-09-29
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
IPC分类号： C12M1/34 , G01N27/26
CPC分类号： G01N27/416 , C12M41/38 , C12M41/46 , G01N27/404 , G01N27/423 , G01N33/48735
摘要： An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.
摘要翻译：一种安排和方法用传感器阵列测量细胞活力。传感器阵列形成在半导体芯片的表面上。半导体芯片具有集成电路，并且集成电路与传感器阵列的每个传感器相关联，用于处理相应传感器的测量信号。集成电路在空间上形成在半导体芯片中，在每个情况下在相关传感器下方，并且传感器阵列的相邻传感器具有在微米范围内的中心到中心。 pH和/或pO2可以在活细胞的环境中测量。

6. 发明授权

US07670557B2 Planar sensor arrangement, sensor array and method for the production of a planar-sensor arrangement 有权
标题翻译：平面传感器布置，传感器阵列和生产平面传感器装置的方法
公开(公告)号：US07670557B2
公开(公告)日：2010-03-02
申请号：US11631380
申请日：2005-06-30
申请人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N31/00
CPC分类号： G01N33/5438 , G01N27/02 , G01N27/3276
摘要： A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilized. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.
摘要翻译：公开了一种平面传感器装置，其用于检测可能包含在分析物中的颗粒。传感器元件包括衬底，第一平面传感器电极和第二平面传感器电极，其形成在衬底上和/或衬底中，并且捕获剂分子可以被固定。第一传感器电极和第二传感器电极分别分成多个平面传感器电极部分区域。第一传感器电极的传感器电极部分区域和第二传感器电极的传感器电极部分区域在基板的表面上以二维交替排列。传感器元件还包括布线结构，通过该布线结构，传感器电极的至少一部分第一传感器电极的部分区域电耦合在一起，并且第二传感器电极的传感器电极部分区域的至少一部分电耦合在一起。

7. 发明申请

US20090284757A1 Method and apparatus for the determination of the 3D coordinates of an object 有权
标题翻译：用于确定物体的3D坐标的方法和装置
公开(公告)号：US20090284757A1
公开(公告)日：2009-11-19
申请号：US12383519
申请日：2009-03-25
申请人： Thomas Mayer , Marcus Steinbichler , Alexander Frey
发明人： Thomas Mayer , Marcus Steinbichler , Alexander Frey
IPC分类号： G01B11/24
CPC分类号： G01B11/25
摘要： In a method for the determination of the 3D coordinates of an object (2), a pattern is projected (1) onto the object (2) and the pattern reflected by the object (2) is taken (3) and evaluated. To improve such a method, a pattern is projected onto a first part region (12) of the object (2) in a first step and the pattern reflected by this part region (12) of the object (2) is taken. In a second step, a pattern is projected onto a second part region of the object (2) and the pattern reflected by this part region of the object (2) is taken. The patterns taken are evaluated (FIG. 3).
摘要翻译：在用于确定对象（3）的3D坐标的方法中，将图案投影（1）到对象（2）上，并且取得由对象（2）反射的图案（3）并进行评估。为了改善这种方法，在第一步骤中将图案投影到物体（2）的第一部分区域（12）上，并且拍摄由物体（2）的该部分区域（12）反射的图案。在第二步骤中，将图案投影到物体（2）的第二部分区域上，并且拍摄由物体（2）的该部分区域反射的图案。评估所采用的图案（图3）。

8. 发明申请

US20070080060A1 Potentiostatic circuit arrangement on a biosensor for digitisation of the measured current 有权
标题翻译：用于数字化测量电流的生物传感器上的静电电路布置
公开(公告)号：US20070080060A1
公开(公告)日：2007-04-12
申请号：US10556731
申请日：2004-05-11
申请人： Alexander Frey , Chirstian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Chirstian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： G01R19/252 , C12Q1/6825 , G01N27/3276
摘要： A circuit arrangement, an electrochemical sensor, a sensor arrangement, and a method for processing a current signal provided by a sensor electrode are disclosed. The circuit arrangement includes a sensor electrode, a first circuit unit, electrically coupled to the sensor electrode and a second circuit unit, including a first capacitor, whereby the first circuit arrangement is embodied to hold the electrical potential of the sensor electrode in a given first reference range about a set electrical potential and, when the sensor electrode potential falls outside the first reference range, the first capacitor and the sensor electrode are coupled such that a matching of the electrical potentials is possible. The second circuit unit is embodied such that, when the electrical potential of the first capacitor falls outside a second reference range, this event is detected and the first capacitor brought to a first electrical reference potential.
摘要翻译：公开了电路装置，电化学传感器，传感器装置和用于处理由传感器电极提供的电流信号的方法。电路装置包括传感器电极，电耦合到传感器电极的第一电路单元和包括第一电容器的第二电路单元，由此第一电路装置被实施为将传感器电极的电势保持在给定的第一参考范围关于设定的电位，并且当传感器电极电位落在第一参考范围之外时，第一电容器和传感器电极被耦合，使得电位的匹配是可能的。实施第二电路单元，使得当第一电容器的电位落在第二参考范围之外时，检测到该事件，并将第一电容器带到第一电参考电位。

9. 发明申请

US20050068046A1 Circuit arrangement, electrochemical sensor, sensor arrangement, and method for processing a current signal provided via a sensor electrode 有权
标题翻译：电路布置，电化学传感器，传感器布置和用于处理经由传感器电极提供的电流信号的方法
公开(公告)号：US20050068046A1
公开(公告)日：2005-03-31
申请号：US10913706
申请日：2004-08-05
申请人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
发明人： Alexander Frey , Christian Paulus , Meinrad Schienle , Roland Thewes
IPC分类号： G01N27/416 , G01N27/02 , G01N27/327 , G01N27/403 , G01N37/00 , G01R27/26
CPC分类号： G01N27/3276
摘要： Circuit arrangement having a sensor electrode, a first circuit unit, which is electrically coupled to the sensor electrode, and a second circuit unit, which has a first capacitor. The first circuit unit holds an electrical potential of the sensor electrode in a predetermined first reference range around a predetermined electrical desired potential by coupling the first capacitor and the sensor electrode such that there is a matching of their electrical potentials. If the second circuit unit detects the electrical potential of the first capacitor being outside a second reference range, the second circuit unit brings the first capacitor to a first electrical reference potential.
摘要翻译：具有传感器电极，电耦合到传感器电极的第一电路单元和具有第一电容器的第二电路单元的电路装置。第一电路单元通过将第一电容器和传感器电极耦合使得存在与它们的电位相匹配的方式，将传感器电极的电位保持在预定的电气期望电位周围的预定的第一参考范围内。如果第二电路单元检测到第一电容器的电位在第二参考范围之外，则第二电路单元将第一电容器引入第一电参考电位。

10. 发明申请

US20130284928A1 DEVICE AND SYSTEM FOR SELECTIVELY DETECTING GAS COMPONENTS OR CONCENTRATIONS OF GAS COMPONENTS IN GAS TO BE ANALYZED AND METHOD FOR OPERATING SUCH DEVICE 有权
标题翻译：选择性地检测要分析的气体中的气体组分的气体组分或浓度的装置和系统以及用于操作这些装置的方法
公开(公告)号：US20130284928A1
公开(公告)日：2013-10-31
申请号：US13817413
申请日：2011-08-11
申请人： Alexander Frey , Harry Hedler , Philip Clissold Howell
发明人： Alexander Frey , Harry Hedler , Philip Clissold Howell
IPC分类号： G01N33/00
CPC分类号： G01N33/0027 , B82Y20/00 , G01J3/108 , G01N21/0303 , G01N21/3504 , G01N21/774 , G01N21/7746 , G02B6/1225
摘要： A photonic crystal, which is a periodically arranged structure made of free-standing columns, has a base material of at least one metal or a metal alloy. Intermediate spaces between the columns allow passage of a gas to be analyzed. The photonic crystal has predefined imperfections, by which at least one resonator is formed, the resonant frequency of which is in a frequency range which is absorbed by a gas component to be detected. A heating unit heats at least some of the columns and at least one detector element extracts the energy present in the resonator in the heated state under the action of the gas to be analyzed. The device may have extremely small dimensions and very low energy consumption.
摘要翻译：作为由独立柱构成的周期性排列的结构的光子晶体具有至少一种金属或金属合金的基材。列之间的中间空间允许待分析的气体通过。光子晶体具有预定义的缺陷，由此形成至少一个谐振器，其谐振频率处于被待检测的气体成分吸收的频率范围内。加热单元加热至少一些列，并且至少一个检测器元件在待分析气体的作用下以加热状态提取谐振器中存在的能量。该装置可能具有非常小的尺寸和非常低的能量消耗。

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