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1. 发明申请

US20140326867A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140326867A1
公开(公告)日：2014-11-06
申请号：US14270433
申请日：2014-05-06
申请人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

2. 发明授权

US08735808B2 Method of mass spectrometry and mass spectrometer using peak deconvolution 有权
标题翻译：使用峰值去卷积的质谱法和质谱仪的方法
公开(公告)号：US08735808B2
公开(公告)日：2014-05-27
申请号：US13576344
申请日：2011-02-14
申请人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
发明人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
IPC分类号： H01J49/40 , G01R23/16
CPC分类号： H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitized by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.
摘要翻译：公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

3. 发明申请

US20130168546A1 Method of Mass Spectrometry and Mass Spectrometer Using Peak Deconvolution 有权
标题翻译：使用峰值去卷积的质谱法和质谱仪的方法
公开(公告)号：US20130168546A1
公开(公告)日：2013-07-04
申请号：US13576344
申请日：2011-02-14
申请人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
发明人： Richard Denny , Keith Richardson , Martin Raymond Green , Steven Derek Pringle , Anthony James Gilbert , John Skilling , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein a signal output from an ion detector is digitised by an Analogue to Digital Converter and is then deconvoluted to determine one or more ion arrival times and one more ion arrival intensities. The process of deconvoluting the ion signal involves determining a point spread function characteristic of an ion arriving at and being detected by the ion detector. A distribution of ion arrival times which produces a best fit to the digitised signal is then determined given that each ion arrival is assumed to produce a response given by the point spread function. A plurality of ion arrival times are then combined to produce a composite ion arrival time-intensity spectrum.
摘要翻译：公开了一种质谱法，其中从离子检测器输出的信号被模拟数字转换器数字化，然后进行解卷积，以确定一个或多个离子到达时间和一个离子到达强度。去卷积离子信号的过程涉及确定到达并被离子检测器检测的离子的点扩散函数特征。因此，假设每个离子到达产生由点扩散函数给出的响应，则确定产生与数字化信号最佳拟合的离子到达时间的分布。然后将多个离子到达时间组合以产生复合离子到达时间强度谱。

4. 发明授权

US09136098B2 Ion guide coupled to MALDI ion source 有权
标题翻译：离子导轨耦合到MALDI离子源
公开(公告)号：US09136098B2
公开(公告)日：2015-09-15
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/40 , H01J49/10 , H01J49/06 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energized one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

5. 发明授权

US08952320B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08952320B2
公开(公告)日：2015-02-10
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

6. 发明申请

US20140191123A1 Ion Guide Coupled to MALDI Ion Source 有权
标题翻译：离子导向器与MALDI离子源耦合
公开(公告)号：US20140191123A1
公开(公告)日：2014-07-10
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/10 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

7. 发明授权

US08153960B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08153960B2
公开(公告)日：2012-04-10
申请号：US11916438
申请日：2006-06-05
申请人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译：公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

8. 发明授权

US08076637B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08076637B2
公开(公告)日：2011-12-13
申请号：US12524378
申请日：2008-01-25
申请人： Steven Derek Pringle , Jason Lee Wildgoose
发明人： Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

9. 发明申请

US20090194688A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090194688A1
公开(公告)日：2009-08-06
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

10. 发明申请

US20090173877A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090173877A1
公开(公告)日：2009-07-09
申请号：US12092601
申请日：2005-11-10
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译：公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器）。在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。

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