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1. 发明授权

US11618766B2 Method for preparing 16Alpha-hydroxyprednisolone 有权
公开(公告)号：US11618766B2
公开(公告)日：2023-04-04
申请号：US17933850
申请日：2022-09-20
申请人： ZHEJIANG SHENZHOU PHARMACEUTICAL COMPANY LIMITED
发明人： Zhenping Shao , Rong Wang , Kegang Chen , Bingqian Wang , Youfu Wang
IPC分类号： C07J7/00 , C07B35/06
摘要： Disclosed in the present disclosure is a method for preparing 16alpha-hydroxyprednisolone, belonging to the technical field of medicine preparation and processing. In the method, 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione-21-acetate is used as a starting material, and subjected to oxidation, bromo-hydroxylation, debromination and alcoholysis, so as to prepare 16alpha-hydroxyprednisolone. The method for preparing 16alpha-hydroxylprednisolone of the present disclosure can effectively control the generation of impurities in the reaction process by improving the disadvantages of traditional processes, and has a mild reaction process and a high overall conversion rate; and the method of the present disclosure has low requirements for a reaction device and low operation costs, is easy to operate, is suitable for industrial production, and has a good market prospect.

2. 发明授权

US11541376B2 Supported catalyst, its activated form, and their preparation and use 有权
公开(公告)号：US11541376B2
公开(公告)日：2023-01-03
申请号：US15899988
申请日：2018-02-20
申请人： CHINA PETROLEUM & CHEMICAL CORPORATION , BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION
发明人： Wei Dai , Haibin Jiang , Shuliang Lu , Xiaohong Zhang , Guoqing Wang , Jinliang Qiao , Hui Peng
IPC分类号： C07C5/02 , B01J25/02 , B01J25/00 , C07B35/02 , C07B35/06 , C07B35/04 , B01J31/28 , B01J31/34 , B01J37/00 , C07C1/04 , C07C1/06 , C07C29/141
摘要： A supported catalyst and preparation method thereof, the catalyst comprising an organic polymer material carrier and Raney alloy particles supported on the organic polymer material carrier, wherein substantially all of the Raney alloy particles are partially embedded in the organic polymer material carrier. The catalyst can be used in hydrogenation, dehydrogenation, amination, dehalogenation or desulfuration reactions.

3. 发明授权

US09695094B2 Production of aromatics from di- and polyoxygenates 有权
公开(公告)号：US09695094B2
公开(公告)日：2017-07-04
申请号：US15217715
申请日：2016-07-22
申请人： Virent, Inc.
发明人： Taylor Beck , Brian Blank , Casey Jones , Elizabeth Woods , Randy Cortright
IPC分类号： C07D321/00 , C07C1/00 , C07C49/00 , C07C27/10 , C07B35/06 , C07C1/24 , B01J23/835 , C07C1/207 , C07C29/60 , C07D301/02 , B01J23/14 , C10G3/00 , B01J38/02 , B01J38/12 , B01J21/06 , B01J23/652 , B01J23/888 , B01J29/46 , B01J29/90 , B01J37/02 , C07C45/00 , C07C51/377 , B01J23/755
CPC分类号： C07B35/06 , B01J21/066 , B01J23/14 , B01J23/6527 , B01J23/755 , B01J23/835 , B01J23/888 , B01J29/46 , B01J29/90 , B01J37/0201 , B01J37/0213 , B01J38/02 , B01J38/12 , C07C1/2072 , C07C1/24 , C07C29/60 , C07C45/002 , C07C51/377 , C07D301/02 , C10G3/46 , C10G3/47 , C10G3/48 , C10G3/49 , C10G3/50 , C10G2300/1014 , C10G2400/30 , Y02P20/584 , Y02P20/588 , Y02P30/20
摘要： Methods, catalysts, and reactor systems for producing in high yield aromatic chemicals and liquid fuels from a mixture of oxygenates comprising di- and polyoxygenates are disclosed. Also disclosed are methods, catalysts, and reactor systems for producing aromatic chemicals and liquid fuels from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like; and methods, catalysts, and reactor systems for producing the mixture of oxygenates from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like. The disclosed catalysts for preparing the mixture of oxygenates comprise a NinSnm alloy and a crystalline alumina support.

4. 发明申请

US20160362346A1 Production of Aromatics from Di- and Polyoxygenates 有权
标题翻译：二氧化碳和多氧化合物生产芳烃
公开(公告)号：US20160362346A1
公开(公告)日：2016-12-15
申请号：US15233466
申请日：2016-08-10
申请人： Virent, Inc.
发明人： Taylor Beck , Brian Blank , Casey Jones , Elizabeth Woods , Randy Cortright
IPC分类号： C07B35/06 , B01J23/755 , B01J23/652 , C10G3/00 , B01J23/835
CPC分类号： C07B35/06 , B01J21/066 , B01J23/14 , B01J23/6527 , B01J23/755 , B01J23/835 , B01J23/888 , B01J29/46 , B01J29/90 , B01J37/0201 , B01J37/0213 , B01J38/02 , B01J38/12 , C07C1/2072 , C07C1/24 , C07C29/60 , C07C45/002 , C07C51/377 , C07D301/02 , C10G3/46 , C10G3/47 , C10G3/48 , C10G3/49 , C10G3/50 , C10G2300/1014 , C10G2400/30 , Y02P20/584 , Y02P20/588 , Y02P30/20
摘要： Methods, catalysts, and reactor systems for producing in high yield aromatic chemicals and liquid fuels from a mixture of oxygenates comprising di- and polyoxygenates are disclosed. Also disclosed are methods, catalysts, and reactor systems for producing aromatic chemicals and liquid fuels from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like; and methods, catalysts, and reactor systems for producing the mixture of oxygenates from oxygenated hydrocarbons such as carbohydrates, sugars, sugar alcohols, sugar degradation products, and the like. The disclosed catalysts for preparing the mixture of oxygenates comprise a Group VIII metal and a crystalline alumina support.
摘要翻译：公开了用于从含有二氧化物和聚氧化物的含氧化合物的混合物中生产高产率芳族化学品和液体燃料的方法，催化剂和反应器系统。还公开了用于从碳氢化合物如碳水化合物，糖，糖醇，糖分解产物等产生芳族化合物和液体燃料的方法，催化剂和反应器系统; 以及用于从氧化烃如碳水化合物，糖，糖醇，糖降解产物等产生含氧化合物的混合物的方法，催化剂和反应器系统。公开的用于制备含氧化合物混合物的催化剂包括第Ⅷ族金属和结晶氧化铝载体。

5. 发明授权

US5937267A System, device and method for quantification of polychlorobiphenyls 失效
标题翻译：用于定量聚氯联苯的系统，装置和方法
公开(公告)号：US5937267A
公开(公告)日：1999-08-10
申请号：US886542
申请日：1997-07-01
申请人： Kenji Todori , Shuji Hayase , Katsushi Nishizawa , Nobutada Aoki , Hideki Shimada , Naoki Tajima , Kazuo Unoki
发明人： Kenji Todori , Shuji Hayase , Katsushi Nishizawa , Nobutada Aoki , Hideki Shimada , Naoki Tajima , Kazuo Unoki
IPC分类号： A62D3/176 , A62D101/22 , C07B35/06 , C07C25/18 , G01N21/64 , B01J19/12
CPC分类号： A62D3/176 , G01N21/643 , A62D2101/22 , A62D2203/10 , G01N2021/6417
摘要： The present invention is to clear the difficulty in determining the progress of the decomposition reaction of PCBs carried out by a conventional device for decomposing PCBs, and to provide a system for treating PCBs to render them harmless, capable of continuously determining the progress of the decomposition reaction of PCBs at real time by using a predetermined amount of a reaction solution taken out while the decomposition reaction of the PCBs is proceeding.The quantity of the polychlorobiphenyls existing in a polychlorobiphenyl-containing liquid can be determined by the system for treating polychlorobiphenyls to render them harmless according to the present invention in the following manner: a polychlorobiphenyl-containing liquid is irradiated with exciting light of from 400 nm to shorter than 450 nm, that can excite the polychlorobiphenyls, or with exciting light of from 300 nm to shorter than 400 nm, that can excite the decomposition products of the polychlorobiphenyls, and the intensity of the emitted light is measured at a wavelength between 450 nm and 600 nm, both inclusive; and the quantity of the existing polychlorobiphenyls is determined based on one of the values measured, or based on the ratio between the two values measured. The progress of the decomposition reaction of the polychlorobiphenyls can thus be determined, and the polychlorobiphenyls can be fully and sufficiently decomposed.
摘要翻译：本发明是为了清楚确定由用于分解PCB的常规装置进行的PCB的分解反应的进展的困难，并且提供一种用于处理PCB以使其无害的系统，能够连续地确定分解的进展通过使用在PCB的分解反应进行期间取出的预定量的反应溶液来实时地进行PCB的反应。存在于含聚氯联苯的液体中的多氯联苯的量可以通过根据本发明的用于处理聚氯联苯以使其无害化的系统以下列方式确定：将含有聚氯联苯的液体用400nm的激发光照射到小于450nm，可以激发聚氯联苯，或者激发300nm至小于400nm的激发光，其可以激发聚氯联苯的分解产物，并且在450nm的波长处测量发射光的强度和600 nm; 并且基于所测量的一个值或基于所测量的两个值之间的比率来确定现有的聚氯联苯的量。因此可以确定聚氯联苯的分解反应的进展，并且聚氯联苯可以完全和充分地分解。

6. 发明授权

US4929757A Process for the preparation of 3-aminophenyl 2-hydroxy-ethyl sulphone 失效
标题翻译： 3-氨基苯基2-羟基乙基砜的制备方法
公开(公告)号：US4929757A
公开(公告)日：1990-05-29
申请号：US208349
申请日：1988-06-17
申请人： Karl-Josef Herd
发明人： Karl-Josef Herd
IPC分类号： C07B61/00 , B01J23/44 , B01J25/02 , C07B35/06 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/04 , C07C317/14 , C07C317/36
CPC分类号： C07C315/04
摘要： 3-Aminophenyl 2-hydroxyethyl sulphone (I) can be prepared in a high yield and purity by treating 2-chloro-5-nitrophenyl 2-hydroxyethyl sulphone (II) or 4-chloro-3-nitrophenyl 2-hydroxyethyl sulphone (III) with hydrogen in the presence of hydrogenation catalysts in an aqueous or aqueous organic medium. (II) is obtained by reducing 2-chloro-5-nitrobenzenesulphochloride with sodium sulphite and subsequently reacting the product with ethylene oxide.
摘要翻译： 3-氨基苯基2-羟乙基砜（I）可以通过处理2-氯-5-硝基苯基2-羟基乙基砜（II）或4-氯-3-硝基苯基2-羟基乙基磺酸酯（III），以高产率和纯度制备，在氢化催化剂存在下，在含水或有机水介质中。（II）是通过用亚硫酸钠还原2-氯-5-硝基苯磺酰氯并随后使产物与环氧乙烷反应得到的。

7. 发明授权

US4814497A Dehalogenation process 失效
标题翻译：脱卤过程
公开(公告)号：US4814497A
公开(公告)日：1989-03-21
申请号：US861934
申请日：1986-05-12
申请人： K. Pushpananda A. Senaratne
发明人： K. Pushpananda A. Senaratne
IPC分类号： C07B35/06 , C07B31/00 , C07B63/02 , C07C51/00 , C07C51/377 , C07C51/487 , C07C63/70 , C07C65/21 , C07C65/24 , C07C67/00 , C07C67/317 , C07C69/76 , C07C233/81 , C07C235/66 , C07C253/00 , C07C255/52 , C07C255/53 , C07C255/54 , C07C325/00 , C07C327/48 , C07C63/34
CPC分类号： C07C51/377
摘要： Particulate aluminum is intimately mixed with an aromatic material that contains at least one ar-halo substituent having an atomic number above 20 and at least one side-chain halo substituent having an atomic number below 20 in the presence of an aqueous alkali or alkaline earth metal hydroxide so as to effect selective removal of the ar-halo substituent.
摘要翻译：颗粒铝与含有至少一个原子数大于20的卤素取代基和至少一个原子序数低于20的侧链卤代基取代基在碱金属或碱土金属水溶液的芳族材料上充分混合氢氧化物，以便实现选择性除去芳卤基取代基。

8. 发明授权

US4317920A Arylacetic acid derivatives 失效
标题翻译：芳基乙酸衍生物
公开(公告)号：US4317920A
公开(公告)日：1982-03-02
申请号：US041106
申请日：1979-05-21
申请人： Endre Palosi , Dezso Korbonits , Pal Kiss , Csaba Gonczy , Gergely Heja , Judit Cser nee Kun , Rudolf Szebeni , Maria Szomor nee Wundele , Ida Szvoboda nee Kanzel
发明人： Endre Palosi , Dezso Korbonits , Pal Kiss , Csaba Gonczy , Gergely Heja , Judit Cser nee Kun , Rudolf Szebeni , Maria Szomor nee Wundele , Ida Szvoboda nee Kanzel
IPC分类号： C07D333/24 , C07B31/00 , C07B35/06 , C07C37/055 , C07C41/32 , C07C43/215 , C07C43/295 , C07C45/67 , C07C45/71 , C07C51/00 , C07C51/377 , C07C57/30 , C07C57/58 , C07C59/64 , C07C59/76 , C07C67/00 , C07C239/00 , C07C271/58 , C07C275/70 , C07C301/00 , C07C303/06 , C07C303/22 , C07C303/32 , C07C305/22 , C07C309/63 , C07C309/66 , C07C309/73 , C07C381/00 , C07D257/04 , C07D263/56 , C07D333/22 , C07C131/00 , C07C125/06
CPC分类号： C07C309/73 , C07C309/66 , C07C37/055 , C07C41/16 , C07C41/32 , C07C45/67 , C07C45/71 , C07C51/377
摘要： Arylacetic acid derivatives of the formula ##STR1## with R.sup.1, R.sup.2 and R.sup.3 specifically defined and which are useful as antirheumatic and antiinflammatory pharmaceuticals are practiced by catalytic hydrogenation of new compounds of the formula ##STR2## in which R and R.sup.10 are also specifically defined. The method of making the latter compound is also set forth.
摘要翻译：具有R1，R2和R3特异性定义并且可用作抗风湿和抗炎药物的式“IMAGE”的芳基乙酸衍生物通过催化氢化式（IMAGE）的新化合物来进行，其中R和R 10也被具体定义。还阐述了制备后一种化合物的方法。

9. 发明授权

US3923832A Insecticidal substituted alkenes 失效
标题翻译：杀虫剂取代烯烃
公开(公告)号：US3923832A
公开(公告)日：1975-12-02
申请号：US35497073
申请日：1973-04-27
申请人： LILLY CO ELI
发明人： LEOPOLD ERIC JAN
IPC分类号： C07C69/767 , A01N29/02 , A01N43/08 , A01N43/30 , A01N49/00 , C07B31/00 , C07B35/06 , C07C1/00 , C07C1/24 , C07C1/32 , C07C15/40 , C07C17/00 , C07C17/26 , C07C22/02 , C07C22/04 , C07C25/02 , C07C25/24 , C07C41/00 , C07C43/20 , C07C43/215 , C07C67/00 , C07C69/618 , C07C201/00 , C07C205/11 , C07C209/00 , C07C211/21 , C07C211/44 , C07C211/48 , C07C253/00 , C07C255/06 , C07C255/50 , C07C255/62 , C07D307/36 , C07D317/50 , C07D333/06 , C07D333/08 , C07D333/12 , C07F9/40 , C07D319/18
CPC分类号： C07F9/4056 , C07C17/2635 , C07D317/50 , C07D333/08 , C07D333/12 , C07C25/24
摘要： wherein each of R1, R2 and R3 can be hydrogen or C1-C3 alkyl, and Z1 and Z2 separately can be hydrogen or halogen or together can be a carbon to carbon bond, and Y is thienyl, furyl, naphthyl, phenyl or phenyl substituted by one or two substituents selected from chloro, bromo, fluoro, carboethoxy, cyano, C1-C4 alkyl, C1-C3 alkoxy, nitro, methylenedioxy, ethylenedioxy, dimethylamino or diethylamino. A compound exemplary of my invention is 4,8-dimethyl-1-(3,4-methylenedioxyphenyl)-1,7nonadiene.

Novel 1,7-dienes and addition products thereof possessing juvenile hormone-like activity have been prepared. Such a compound is one having the formula
摘要翻译：已经制备出具有幼体激素样活性的新颖的1,7-二烯及其加成产物。这种化合物是具有式Z1Z2 || Y-CH = CH-CH2CHCH2CH2CH-C-R3 || R1R2的化合物，其中R1，R2和R3各自可以是氢或C1-C3烷基，Z1和Z2可以分别是氢或卤素或一起可以是碳 - 碳键，Y是噻吩基，呋喃基，萘基，苯基或被一个或两个选自氯，溴，氟，乙酰乙氧基，氰基，C 1 -C 4烷基，C 1 -C 3 烷氧基，硝基，亚甲二氧基，亚乙二氧基，二甲基氨基或二乙基氨基。本发明的化合物是4,8-二甲基-1-（3,4-亚甲二氧基苯基）-1,7-壬二烯。

10. 发明授权

US1873536A Process for producing reaction products from hydrocarbons and water 失效
标题翻译：从碳氢化合物和水生产反应产物的方法
公开(公告)号：US1873536A
公开(公告)日：1932-08-23
申请号：US19820227
申请日：1927-06-11
申请人： BROWN RALPH L , ODELL WILLIAM W
发明人： BROWN RALPH L , ODELL WILLIAM W
IPC分类号： C07B35/06 , C07C29/00 , C07C29/04 , C07C41/00
CPC分类号： C07C29/04 , C07B35/06 , C07C29/00 , C07C41/01 , C07C43/04 , C07C31/08 , C07C33/22

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