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1. 发明授权

US08946224B2 Substituted [1,2,4]triazolo[4,3-A]pyrazines for medicaments and pharmaceutical compositions 有权
标题翻译：用于药物和药物组合物的取代的[1,2,4]三唑并[4,3-A]吡嗪
公开(公告)号：US08946224B2
公开(公告)日：2015-02-03
申请号：US13883713
申请日：2011-11-11
申请人： Mark Craighead , Ronald Palin , Neil Murray , Derek Lindsay
发明人： Mark Craighead , Ronald Palin , Neil Murray , Derek Lindsay
IPC分类号： A61K31/4985 , C07D487/04 , C07D498/06 , C07D413/12 , C07C63/64 , C07D213/60 , C07C217/58 , C07D403/06 , C07C69/12 , C07C235/16 , C07D257/04 , C07D313/04 , C07D407/06 , C07C43/205 , C07C215/46 , C07C255/25 , C07D205/08 , C07D281/06 , C07D417/06 , C07D413/04 , C07D401/04 , C07C63/66 , C07D499/88 , C07D401/12 , C07D519/00 , C07D209/18 , C07D307/00 , C07D501/00 , C07C233/22 , C07D473/00 , C07H19/052 , C07C251/40 , C07D403/12 , C07D513/06 , C07C251/54 , C07C257/14 , C07C251/48 , C07C57/00 , C07C233/36 , C07H19/173 , C07D411/10 , C07C229/18 , C07D295/02 , C07H19/06 , C07C235/28 , C07D233/54 , C07J5/00 , C07D471/04 , C07D241/04 , C07D235/16 , C07D277/40 , C07D417/12 , C07D309/32 , C07C237/20 , C07C251/58 , C07D401/14 , C07D491/04
CPC分类号： C07D487/04 , C07C43/205 , C07C57/00 , C07C63/64 , C07C63/66 , C07C69/12 , C07C215/46 , C07C217/58 , C07C229/18 , C07C233/22 , C07C233/36 , C07C235/16 , C07C235/28 , C07C237/20 , C07C251/40 , C07C251/48 , C07C251/54 , C07C251/58 , C07C255/25 , C07C257/14 , C07C2601/16 , C07C2602/10 , C07C2603/74 , C07D205/08 , C07D209/18 , C07D213/60 , C07D233/54 , C07D235/16 , C07D241/04 , C07D257/04 , C07D277/40 , C07D281/06 , C07D295/02 , C07D307/00 , C07D309/32 , C07D313/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D407/06 , C07D411/10 , C07D413/04 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D473/00 , C07D491/04 , C07D498/06 , C07D499/88 , C07D501/00 , C07D513/06 , C07D519/00 , C07H19/052 , C07H19/06 , C07H19/173 , C07J5/00 , C07J71/0031
摘要： The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. Exemplary derivatives have the formula
摘要翻译：本发明涉及已知的活性药物化合物的衍生物。由于活性化合物的氧化还原衍生物，这些衍生物与母体活性化合物不同。这意味着活性化合物中的一个或多个官能团已经在一个或多个反应中被转化为另一个基团，这可被认为代表氧化态的变化。我们通常将这些化合物称为氧化还原衍生物。本发明的衍生物可以仅通过单步转化与原始的母体活性药物化合物相关，或者可以通过包括氧化态的一个或多个变化的几个合成步骤相关。示例性衍生物具有式

2. 发明授权

US5696239A Conjugates possessing ortho ligating functionality and complexes thereof 失效
标题翻译：具有邻接结合官能团的结合体及其复合物
公开(公告)号：US5696239A
公开(公告)日：1997-12-09
申请号：US468957
申请日：1995-06-06
申请人： David A. Wilson , Joseph R. Garlich , R. Keith Frank , Kenneth McMillan
发明人： David A. Wilson , Joseph R. Garlich , R. Keith Frank , Kenneth McMillan
IPC分类号： A61K51/04 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/00 , G01N33/534 , C07F3/00 , A61K43/00 , A61K49/02
CPC分类号： G01N33/534 , A61K51/0478 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译：公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。此外，某些螯合剂 - 放射性核素复合物可以有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。

3. 发明授权

US5476960A .alpha.aminonitriles derived from reaction of carbonyl compounds and fatty aklyl alkylene diamines 失效
标题翻译：衍生自羰基化合物和脂肪亚烷基亚烷基二胺反应的α氨基腈
公开(公告)号：US5476960A
公开(公告)日：1995-12-19
申请号：US224353
申请日：1994-04-07
申请人： Alison A. Fleming , Robert F. Farmer , James F. Gadberry
发明人： Alison A. Fleming , Robert F. Farmer , James F. Gadberry
IPC分类号： C07C255/25 , C07C255/46 , C07C255/30 , C07C255/04 , C07C255/33
CPC分类号： C07C255/25 , C07C255/46 , C07C2101/14
摘要： An .alpha.-aminonitrile compound derived from the reaction, in the presence of a cyanide source of (1) a bisulfite adduct of a carbonyl compound selected from the group consisting of an aldehyde and a ketone with (2) a fatty alkyl alkylene diamine containing two reactible amino functionalities which is of the formula RNHR.sub.1 NH.sub.2, where R is fatty alkyl and R.sub.1 is lower alkylene of up to six carbon atoms.
摘要翻译：在氰化物源的存在下，（1）选自醛和酮的羰基化合物的亚硫酸氢盐加合物与（2）含有2个脂肪烷基亚烷基二胺的氰化物源的α-氨基腈化合物可反应的氨基官能团，其具有式RNHR1NH2，其中R是脂肪烷基，R1是至多6个碳原子的低级亚烷基。

4. 发明授权

US5393913A N-formylanilines 失效
标题翻译： N-甲酰苯胺
公开(公告)号：US5393913A
公开(公告)日：1995-02-28
申请号：US25503
申请日：1993-03-03
申请人： Thierry Aubert
发明人： Thierry Aubert
IPC分类号： C07C255/23 , C07C233/15 , C07C255/24 , C07C255/25 , C07C323/27 , C07C327/42 , C07D233/84 , C07C255/02 , C07C327/06 , C07D233/04
CPC分类号： C07D233/84 , C07C233/15 , C07C255/24 , C07C255/25 , C07C327/42
摘要： The present invention relates to N-carbonyl anilines which are intermediates for the preparation of pesticidal 1-aryl imidazoles and to processes for making them.
摘要翻译：本发明涉及作为制备杀虫剂1-芳基咪唑的中间体的N-羰基苯胺及其制备方法。

5. 发明授权

US5306692A Herbicidal indazole and benzimidazole compounds 失效
标题翻译：除草吲唑和苯并咪唑化合物
公开(公告)号：US5306692A
公开(公告)日：1994-04-26
申请号：US652337
申请日：1991-02-07
申请人： John E. D. Barton , David Cartwright , Derek McCormack
发明人： John E. D. Barton , David Cartwright , Derek McCormack
IPC分类号： A01N43/52 , A01N43/56 , C07C205/38 , C07C217/90 , C07C255/25 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/16 , C07D235/24 , C07D401/12 , C07D403/12 , C07D213/30 , A01N43/50 , C07D235/26
CPC分类号： C07D235/24 , C07C205/38 , C07C217/90 , C07C255/25 , C07D231/56 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/16 , C07D401/12
摘要： A herbicidal compound of formula (I): ##STR1## or N-oxide or quaternised derivative thereof; Ar is an optionally substituted aryl or heterocyclic ring system;W is O or NR.sup.1 where R.sup.1 is H or lower alkyl;A, B, D are independently selected from N, NR.sup.2, N--E, CR.sup.6, C--E or C(R.sup.6)E;wherein E is: ##STR2## provided 2 of A, B and D are N, NR.sup.2 or N--E; one of A, B and D is CR.sup.6, C--E or C(R.sup.6) E and at least one of A, B or D carries a group E;where R.sup.2 is H, OR.sup.7, CN, COOR.sup.8, alkyl or haloalkyl;R.sup.3 and R.sup.4 are independently selected from H, optionally substituted alkyl, alkenyl or alkynyl, halogen, NR.sup.9 R.sup.10, or R.sup.3 and R.sup.4 together with the carbon to which they are attached form an optically substituted alkenyl or cycloalkyl group;X is (CH.sub.2).sub.n, CH.dbd.CH, CH(OR.sup.16)CH.sub.2 or COCH.sub.2 where n is O, 1 or 2;R.sup.5 is CO.sub.2 R.sup.11, CN, COR.sup.11, CH(OH)R.sup.11, CH(OR.sup.11)R.sup.12, CSNH.sub.2, COSR.sup.11, CSOR.sup.11, CONHSO.sub.2 R.sup.11, CONR.sup.13 R.sup.14, CONHNR.sup.13 R.sup.14 R.sup.15 Y.sup.-, CO.sub.2,.sup.- M.sup.+ or COON.dbd.CR.sup.13 R.sup.14 ;R.sup.6 is H, halogen, OR.sup.7, CN, COOR.sup.8, alkyl or haloalkyl; andR.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup.14, R.sup.15 and R.sup.16 are specified organic groups.
摘要翻译：式（I）的除草化合物：其中：（I）或其N-氧化物或季铵化衍生物; Ar是任选取代的芳基或杂环系; W是O或NR1，其中R1是H或低级烷基; A，B，D独立地选自N，NR2，N-E，CR6，C-E或C（R6）E; 其中E为：提供A的2个，B和D为N，NR 2或N-E; A，B和D之一是CR6，C-E或C（R6）E，A，B或D中的至少一个携带E组; 其中R 2是H，OR 7，CN，COOR 8，烷基或卤代烷基; R 3和R 4独立地选自H，任选取代的烷基，烯基或炔基，卤素，NR 9 R 10或R 3和R 4与它们所连接的碳一起形成光学取代的烯基或环烷基; X是（CH 2）n，CH = CH，CH（OR 16）CH 2或COCH 2，其中n是O，1或2; R5是CO 2 R11，CN，COR11，CH（OH）R11，CH（OR11）R12，CSNH2，COSR11，CSOR11，CONHSO2R11，CONR13R14，CONHNR13R14R15Y-，CO2，-M +或COON = CR13R14; R6是H，卤素，OR7，CN，COOR8，烷基或卤代烷基; 并且R 7，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15和R 16是指定的有机基团。

6. 发明授权

US5208363A Preparation of aminonitriles 失效
标题翻译：氨基腈的制备
公开(公告)号：US5208363A
公开(公告)日：1993-05-04
申请号：US878572
申请日：1992-05-05
申请人： Druce K. Crump , David A. Wilson
发明人： Druce K. Crump , David A. Wilson
IPC分类号： C07C255/25
CPC分类号： C07C255/25
摘要： The present invention is a process for preparing aminoacetonitriles or ethylenediamine tetraacetonitrile comprising the steps of (a) admixing glycolonitrile with an amine having at least one primary amine group or ethylenediamine to form an intermediate amine acetonitrile reaction product, (b) admixing the reaction product of Step (a) with formaldehyde and hydrocyanic acid such that each hydrogen on an amine nitrogen is replaced by an acetonitrile group. The resulting aminoacetonitrile advantageously has all amino groups fully substituted with acetonitrile groups.
摘要翻译：本发明是制备氨基乙腈或乙二胺四乙腈的方法，包括以下步骤：（a）将乙醇腈与具有至少一个伯胺基或乙二胺的胺混合以形成中间体胺乙腈反应产物，（b）将步骤（a）用甲醛和氢氰酸使胺氮上的每个氢被乙腈基团代替。所得氨基乙腈有利地具有完全被乙腈基团取代的所有氨基。

7. 发明授权

US5008428A Integrated process for the production of aminoacetonitriles 失效
标题翻译：生产氨基乙腈的综合工艺
公开(公告)号：US5008428A
公开(公告)日：1991-04-16
申请号：US425438
申请日：1989-10-26
申请人： Martin B. Sherwin , Jow-Lih Su
发明人： Martin B. Sherwin , Jow-Lih Su
IPC分类号： C07C255/25
CPC分类号： C07C255/25 , Y02P20/125
摘要： This invention relates to the production of aminoacetonitriles, and more specifically to an integrated process wherein a crude, unpurified reactor product stream from a hydrogen cyanide reactor together with a formaldehyde stream, optionally, a crude, unpurified reactor product stream from a formaldehyde process reactor are fed directly to a reactive absorber with an additional nitrogen source and scrubbed with a controlled pH aqueous solution to produce aminoacetonitriles in high yields. This process eliminates intermediate recovery and purification processes associated with conventional hydrogen cyanide and formaldehyde production processes by integrating the recovery and reaction processes into a reactive absorber.
摘要翻译：本发明涉及氨基乙腈的制备，更具体地说涉及一种综合方法，其中将来自氰化氢反应器的粗制未纯化反应器产物物流与甲醛流，任选地，来自甲醛工艺反应器的粗制未纯化反应器产物流一起是直接加入具有附加氮源的反应性吸收剂，并用受控的pH水溶液洗涤，以高产率产生氨基乙腈。该方法通过将回收和反应过程整合到反应性吸收剂中来消除与常规氰化氢和甲醛生产方法相关的中间回收和纯化方法。

8. 发明授权

US4478759A Preparation of aminoitriles 失效
标题翻译：氨基腈的制备
公开(公告)号：US4478759A
公开(公告)日：1984-10-23
申请号：US283649
申请日：1981-07-15
申请人： Harry Distler , Karl-Ludwig Hock
发明人： Harry Distler , Karl-Ludwig Hock
IPC分类号： C07C255/24 , C07C255/25 , C07C120/00
CPC分类号： C07C255/00
摘要： Aminonitriles are prepared by reacting a nitrogen compound with formaldehyde and hydrogen cyanide in the presence of an additional acid at a pH below 2 and at from 10.degree. to 70.degree. C., the concentration of the hydrogen cyanide during the reaction being not more than 3 per cent by weight, based on the reaction mixture.The aminoacetonitriles obtained by the novel process are valuable starting materials for the preparation of dyes, fungicides, bactericides, textile assistants, rubber additives, and auxiliaries used in water softening, cosmetics, the photographic industry, the paper industry and the electroplating industry.
摘要翻译：氨基腈是通过使氮化合物与甲醛和氰化氢在另外的酸存在下，在低于2和10至70℃的pH下反应制备的，反应中氰化氢的浓度不大于3 基于反应混合物的重量百分比。通过新方法获得的氨基乙腈是用于制备染料，杀真菌剂，杀菌剂，纺织助剂，橡胶添加剂和用于水软化，化妆品，摄影工业，造纸工业和电镀工业的助剂的有价值的起始材料。

9. 发明授权

US3061628A Process and preparation of amino nitriles and acetic acids 失效
标题翻译：氨基腈和乙酸的工艺和制备
公开(公告)号：US3061628A
公开(公告)日：1962-10-30
申请号：US76055158
申请日：1958-09-12
申请人： HAMPSHIRE CHEMICAL CORP
发明人： SINGER JR JOHN J , MARK WEISBERG
IPC分类号： C07C255/24 , C07C255/25
CPC分类号： C07C255/00

10. 发明授权

US09969690B2 Cure accelerators for anaerobic curable compositions 有权
公开(公告)号：US09969690B2
公开(公告)日：2018-05-15
申请号：US15452768
申请日：2017-03-08
申请人： Henkel IP & Holding GmbH
发明人： Philip T. Klemarczyk
IPC分类号： C08F2/00 , C08F20/06 , C08F118/02 , C07D215/06 , C08F20/28 , C08K5/3437 , C07D209/08 , C08K5/3417 , C07C255/25 , C08K5/315 , C07C253/30 , C07C229/18 , C08K5/18 , C07C227/26
CPC分类号： C07D215/06 , C07C211/48 , C07C227/26 , C07C229/18 , C07C253/30 , C07C255/25 , C07D209/08 , C08F20/28 , C08F220/28 , C08K5/16 , C08K5/18 , C08K5/315 , C08K5/3417 , C08K5/3437 , C09J4/00
摘要： Cure accelerators for anaerobic curable compositions, such as adhesives and sealants, are provided, and which are defined with reference to the compounds shown in structure I where A is CH2 or benzyl, R is C1-10 alkyl, R′ is H or C1-10 alkyl, or R and R′ taken together may form a four to seven membered ring fused to the benzene ring, R″ is optional, but when R″ is present, R″ is halogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, hydroxyalkenyl, alkoxy, amino, alkylene- or alkenylene-ether, alkylene (meth)acrylate, carbonyl, carboxyl, nitroso, sulfonate, hydroxyl or haloalkyl, and EWG is as shown, an electron withdrawing group, such as nitro, nitrile, carboxylate or trihaloalkyl.

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