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21. 发明授权

US5514254A Procedure for the photochlorination of alkyl-aromatic compounds 失效
标题翻译：烷基芳族化合物的光氯化方法
公开(公告)号：US5514254A
公开(公告)日：1996-05-07
申请号：US198576
申请日：1994-02-18
申请人： Carlo Ribaldo , Giuseppe Contardi , Vittorio Messori
发明人： Carlo Ribaldo , Giuseppe Contardi , Vittorio Messori
IPC分类号： C07B39/00 , B01J19/12 , B01J19/24 , C07B61/00 , C07C17/14 , C07C22/04 , C07C25/02 , C07C17/00
CPC分类号： B01J19/123 , B01J19/2415 , C07C17/14 , B01J2219/00144 , Y02P20/582
摘要： An alkyl-aromatic compound is selectively photochlorinated in the side chain in a cyclic reaction system wherein said compound is continuously circulated between a container and photochlorination reactor.The compound is partially chlorinated after each passage through the photochlorination reactor, the number of passages depending on the degree of chlorination required.The procedure is particularly useful for the preparation of benzyl chloride, benzal chloride and benzotrichloride, and the corresponding halogen-substituted derivatives of the nucleus.
摘要翻译：烷基芳族化合物在循环反应体系中在侧链中选择性地被光氯化，其中所述化合物在容器和光氯化反应器之间连续循环。每次通过光氯化反应器后，化合物被部分氯化，通过次数取决于所需的氯化度。该方法对于制备苄基氯，亚苄基氯和苯并三氯化物以及相应的核的卤素取代衍生物特别有用。

22. 发明授权

US5462694A Mesomorphic compound, liquid crystal composition containing the compound, liquid crystal device using the composition, liquid crystal apparatus and display method 失效
标题翻译：介晶化合物，含有该化合物的液晶组合物，使用该组合物的液晶装置，液晶装置和显示方法
公开(公告)号：US5462694A
公开(公告)日：1995-10-31
申请号：US297777
申请日：1994-08-30
申请人： Yoko Kosaka , Takao Takiguchi , Takashi Iwaki , Takeshi Togano , Shinichi Nakamura , Ikuo Nakazawa
发明人： Yoko Kosaka , Takao Takiguchi , Takashi Iwaki , Takeshi Togano , Shinichi Nakamura , Ikuo Nakazawa
IPC分类号： G02F1/13 , C07C13/28 , C07C22/04 , C07C25/18 , C07C43/168 , C07C43/17 , C07C43/21 , C07C43/225 , C07C255/32 , C07C323/16 , C07D215/06 , C07D215/14 , C07D215/20 , C07D215/22 , C07D239/26 , C07D239/34 , C07D263/56 , C07D263/57 , C07D277/22 , C07D277/24 , C07D277/66 , C07D307/42 , C07D307/79 , C07D405/04 , C07D409/10 , C07D409/12 , C07D417/04 , C07D417/12 , C09K19/04 , C09K19/14 , C09K19/32 , C09K19/34 , C09K19/46 , C09K19/30
CPC分类号： C07D263/57 , C07D215/20 , C07D277/22 , C07D277/24 , C07D277/66 , C07D409/10 , C09K19/04 , C09K19/32 , C09K19/3444 , C09K19/3452 , C09K19/3466 , C09K19/3469 , C09K19/3477 , C09K19/3491 , C09K19/3497 , C09K19/46 , C09K19/3405
摘要： A mesomorphic compound of the formula (I) according to claim 1 characterized by having at least one cyclic group selected from .beta. class including, e.g., thiazole-2,5-diyl, benzoxazole-2,5-diyl, indan-2,5-diyl, and quinoxaline-2,6-diyl and also having a linkage of Y.sup.1 (CH.sub.2).sub.m Y.sup.2, where Y.sup.1 and Y.sup.2 are --CH.sub.2 --, --O--, --COO-- or --OCO-- and m is 1-16, is suitable as a component for a liquid crystal composition providing improved response characteristics. A liquid crystal device is constituted by disposing the liquid crystal composition between a pair of substrates. The liquid crystal device is used as a display panel constituting a liquid crystal apparatus providing good display characteristics.
摘要翻译：根据权利要求1的式（I）的介晶化合物，其特征在于具有至少一个选自β类的环状基团，包括例如噻唑-2,5-二基，苯并恶唑-2,5-二基，茚满-2,5- - 二基和喹喔啉-2,6-二基，并且还具有Y 1（CH 2）m Y 2的键，其中Y 1和Y 2是-CH 2 - ， - O - ， - COO-或-OCO-，m是1-16，适合作为提供改善的响应特性的液晶组合物的组分。通过将液晶组合物设置在一对基板之间构成液晶装置。液晶装置用作构成提供良好显示特性的液晶装置的显示面板。

23. 发明授权

US5420343A Derivatives of aromatic cyclic alkylethers 失效
标题翻译：芳环烷基醚的衍生物
公开(公告)号：US5420343A
公开(公告)日：1995-05-30
申请号：US299173
申请日：1994-08-31
申请人： Francis J. Koszyk , Richard M. Weier
发明人： Francis J. Koszyk , Richard M. Weier
IPC分类号： C07C17/12 , C07C17/16 , C07C22/04 , C07C25/02 , C07C33/26 , C07C35/21 , C07C45/44 , C07C45/67 , C07C47/228 , C07C49/657 , C07C59/72 , C07C69/757 , C07C255/33 , C07C309/73 , C07C323/52 , C07D307/20 , C07D493/04 , C07C59/40
CPC分类号： C07D493/04 , C07C17/12 , C07C17/16 , C07C22/04 , C07C25/02 , C07C255/33 , C07C309/73 , C07C323/52 , C07C33/26 , C07C35/21 , C07C45/44 , C07C45/676 , C07C47/228 , C07C49/657 , C07C59/72 , C07C69/757 , C07D307/20
摘要： The present invention provides compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein: R.sup.1 and R.sup.2 are each alkyl;n is an integer of from 1 to 4;x is oxygen or --(CH.sub.2).sub.m --;m is an integer of from 1 to 3;y is oxygen or sulfur; andp is an integer of from 1 to 4.These compounds are inhibitors of COX-I and/or COX-II, and are useful for the treatment of inflammation-associated disorders.The present invention also provides pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for treating inflammation-associated disorders in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
摘要翻译：本发明提供下式的化合物：其中：R 1和R 2各自为烷基; n为1〜4的整数， x是氧或 - （CH 2）m - ; m为1〜3的整数， y是氧或硫; 并且p是1至4的整数。这些化合物是COX-1和/或COX-II的抑制剂，并且可用于治疗炎症相关疾病。本发明还提供药物组合物，其包含治疗有效量的式I化合物与药学上可接受的载体的组合，和用于治疗动物中炎症相关疾病的方法，包括给予治疗有效量的化合物的I型动物。

24. 发明授权

US5385692A Mesomorphic compound, liquid crystal composition, liquid crystal device, display apparatus and display method 失效
标题翻译：介晶化合物，液晶组合物，液晶装置，显示装置及显示方法
公开(公告)号：US5385692A
公开(公告)日：1995-01-31
申请号：US225344
申请日：1994-04-08
申请人： Takashi Iwaki , Takao Takiguchi , Takeshi Togano , Yoko Yamada , Shinichi Nakamura
发明人： Takashi Iwaki , Takao Takiguchi , Takeshi Togano , Yoko Yamada , Shinichi Nakamura
IPC分类号： C07C69/75 , C07C13/45 , C07C13/465 , C07C22/04 , C07C25/22 , C07C25/24 , C07C43/188 , C07C43/21 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/753 , C07C69/757 , C07C69/76 , C07C69/767 , C07C69/773 , C07C69/86 , C07C69/92 , C07C69/94 , C07C255/50 , C07D213/16 , C07D213/30 , C07D213/50 , C07D213/64 , C07D213/65 , C07D237/08 , C07D239/24 , C07D239/26 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D263/58 , C07D277/20 , C07D277/22 , C07D277/66 , C07D285/12 , C07D333/08 , C07D333/16 , C07D333/38 , C07D405/12 , C07D409/12 , C07D417/04 , C09K19/12 , C09K19/20 , C09K19/30 , C09K19/32 , C09K19/34 , C09K19/42 , C09K19/46 , G02F1/13
CPC分类号： C07C13/465 , C07C25/22 , C07C25/24 , C07C43/188 , C07C43/21 , C07C43/215 , C07C43/23 , C07D213/16 , C07D213/30 , C07D213/50 , C07D213/64 , C07D213/65 , C07D237/08 , C07D239/26 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D263/58 , C07D277/22 , C07D277/66 , C07D285/12 , C07D333/08 , C07D333/16 , C07D333/38 , C07D405/12 , C07D409/12 , C07D417/04 , C09K19/32 , C09K19/322 , C09K19/3441 , C09K19/3477 , C09K19/3491 , C09K19/3497 , C09K19/46 , C07C2101/14 , C07C2102/08
摘要： A mesomorphic compound of the formula (I) according to claim 1 is suitable as a component for liquid crystal composition providing improved response characteristics.
摘要翻译：根据权利要求1的式（I）的介晶化合物适合作为提供改善的响应特性的液晶组合物的组分。

25. 发明授权

US5364556A Halovinyl-derivatives 失效
公开(公告)号：US5364556A
公开(公告)日：1994-11-15
申请号：US50477
申请日：1993-05-18
申请人： Martin Schadt , Frank Seils
发明人： Martin Schadt , Frank Seils
IPC分类号： C07C22/00 , C07C22/02 , C07C22/04 , C07C22/08 , C07C25/24 , C07C43/172 , C07C43/176 , C07C43/184 , C07C43/192 , C07C43/20 , C07C43/225 , C07C43/257 , C07C69/75 , C07C69/753 , C07C69/757 , C07C69/76 , C07C255/46 , C07C255/49 , C07C255/50 , C07C323/04 , C07C323/07 , C07D213/26 , C07D213/30 , C07D213/65 , C07D239/26 , C07D239/34 , C07D319/06 , C07D339/08 , C09K19/04 , C09K19/30 , C09K19/34 , C09K19/42 , C09K19/52
CPC分类号： C07C255/50 , C07C25/24 , C07C43/172 , C07C43/176 , C07C43/192 , C07C43/225 , C09K19/04 , C09K19/3001 , C09K19/3402 , C09K19/3441 , C09K19/3469 , C09K19/42 , C07C2101/14 , C09K2019/3422
摘要： Compounds of general formula (I), wherein R signifies hydrogen, halogen, cyano, isothiocyanato, or alkyl, alkenyl or alkynyl with 1 to 15 carbon atoms, which is unsubstituted or substituted with at least one of halogen, cyano and/or trifluoromethyl and in which one or more non-adjacent --CH.sub.2 -- group(s) can be replaced by --O--, --S--, --CO--, --COO-- and/or --OOC--; Q represents alkylene with 2 to 10 carbon atoms, which is unsubstituted or substituted with at least one fluorine and in which one --CH.sub.2 -- group can be replaced by --O--, --S--, --COO--, or --OOC--, or --CH.sub.2 --, --CF.sub.2 --, --CHF-- or a single covalent bond; A.sup.1, A.sup.2, A.sup.3 each independently signify 1,4-phenylene, which is unsubstituted or substituted with at least one of halogen, cyano and/or methyl and in which, when it is unsubstituted, one or more --CH-- groups can be replaced by nitrogen, or unsubstituted or cyano- or fluoro-substituted trans-1,4-cyclohexylene, or 1,4-cyclohexenylene, trans-1,3-dioxane-2,5-diyl or trans-1,3-dithiane-2,5-diyl; A.sup.4 represents unsubstituted or cyano- or fluoro-substituted trans-1,4-cyclohexylene, or 1,4-cyclohexenylene, trans-1,3-dioxane-2,5-diyl, trans-1,3-dithiane-2,5-diyl or, when Q is different from a single covalent bond, also 1,4-phenylene, which is unsubstituted or substituted with at least one of halogen, cyano and/or methyl and in which, when it is unsubstituted, one or more --CH-- groups can be replaced by nitrogen; X.sup.1 represents bromine or chlorine; Z.sup.1, Z.sup.2, Z.sup.3 each independently denote a single covalent bond, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --COO--, --OOC--, --C.tbd.C--, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.3 O--, --O(CH.sub.2).sub.3 --, the trans form of --CH.dbd.CH--, --CH.dbd.CHCH.sub.2 O--, --OCH.sub.2 CH.dbd.CH--, --CH.dbd.CH(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.2 CH.dbd.CH--; n, p each independently signify 0 or 1; R.sup.2, R.sup.3 each independently represent hydrogen or fluorine, as well as liquid crystalline mixtures which contain such compounds and their use for electro-optical purposes.

26. 发明授权

US5230829A Phenylcyclohexanes, and a liquid-crystalline medium 失效
标题翻译： PHYYLCYCLOHEXANES和液晶晶体介质
公开(公告)号：US5230829A
公开(公告)日：1993-07-27
申请号：US679078
申请日：1991-06-24
申请人： Ekkehard Bartmann , Joachim Krause , Eike Poetsch , Reinhard Hittich , Bernhard Rieger , Ulrich Finkenzeller
发明人： Ekkehard Bartmann , Joachim Krause , Eike Poetsch , Reinhard Hittich , Bernhard Rieger , Ulrich Finkenzeller
IPC分类号： C07C22/04 , C07C25/18 , C07C43/225 , C09K19/30 , G02F1/13
CPC分类号： C07C43/225 , C07C25/18 , C09K19/3003 , C09K19/3028 , C07C2101/14
摘要： The invention relates to novel phenylcyclohexanes of the formula I ##STR1## in which Q is CH--Hal or C--Hal.sub.2 where Hal is F or Cl,n is 1 to 5,r is 0 to 6,A is a single bond, ##STR2## X is F, Cl, --CF.sub.3, --OCF.sub.3 or --OCHF.sub.2, and Y and Z are each, independently of one another, H or F.
摘要翻译：本发明涉及式I的新型苯基环己烷，其中Q为CH-Hal或C-Hal2，其中Hal为F或Cl，n为1至5，r为0至6，A为单键， X是F，Cl，-CF 3，-OCF 3或-OCHF 2，Y和Z各自独立地为H或F.

27. 发明授权

US5227560A Chlorination and elimination process and some products thereof 失效
标题翻译：氯化和消除过程及其一些产品
公开(公告)号：US5227560A
公开(公告)日：1993-07-13
申请号：US788902
申请日：1991-11-07
申请人： Katherine S. Clement , W. Frank Richey , Marlin E. Walters
发明人： Katherine S. Clement , W. Frank Richey , Marlin E. Walters
IPC分类号： C07D311/82 , B01J31/02 , C07B35/06 , C07B39/00 , C07B61/00 , C07C1/26 , C07C1/30 , C07C13/465 , C07C13/567 , C07C13/58 , C07C15/40 , C07C17/10 , C07C17/37 , C07C22/04 , C07C23/34 , C07C23/40 , C07C23/42 , C07C49/213 , C07C49/603 , C07C255/34
CPC分类号： C07C1/26 , C07B39/00 , C07C17/10 , C07C2103/18 , C07C2531/02
摘要： Active methine compounds are chlorinated by contacting such compounds with a perchloroalkane and aqueous base in the presence of a phase transfer catalyst which is an tetraalkylonium hydroxide. Chlorinated products, preferably tertiary alkyl chloro compounds, are produced. The tertiary alkyl chloro compounds are useful in elimination reactions, preferably reactions with base, to form unsaturated compounds, particularly compounds having a vinylidene or exomethylene group.
摘要翻译：在相转移催化剂（四烷基氢氧化物）存在下，将这些化合物与全氯烷烃和碱水溶液接触，将活性次甲基化合物氯化。产生氯化产物，优选叔烷基氯化合物。叔烷基氯化合物可用于消除反应，优选与碱反应形成不饱和化合物，特别是具有亚乙烯基或异亚甲基的化合物。

28. 发明授权

US5210352A Fluorene compounds 失效
标题翻译：芴化合物
公开(公告)号：US5210352A
公开(公告)日：1993-05-11
申请号：US705863
申请日：1991-05-28
申请人： Helmut G. Alt , Syriac J. Palackal
发明人： Helmut G. Alt , Syriac J. Palackal
IPC分类号： B01J31/22 , C07C13/567 , C07C22/04 , C07C49/747 , C07C51/31 , C07C51/373 , C07C51/377 , C07C63/331 , C07C63/49 , C07C65/36 , C07F7/08 , C07F17/00 , C08F4/659 , C08F4/6592
CPC分类号： C07C22/04 , C07C13/567 , C07C49/747 , C07C51/31 , C07C51/373 , C07C51/377 , C07C63/331 , C07C63/49 , C07C65/36 , C07F17/00 , C07F7/0809 , C07F7/0818 , B01J31/2295 , C07C2101/10 , C07C2103/18 , C08F4/65912 , C08F4/65927
摘要： New fluorene derivatives and new methods for forming fluorene derivatives are disclosed. Examples include processes for preparing tert-butyl substituted fluorenes, 1-methyl fluorene, and 4-methyl fluorene.
摘要翻译：公开了新的芴衍生物和形成芴衍生物的新方法。实例包括制备叔丁基取代芴，1-甲基芴和4-甲基芴的方法。

29. 发明授权

US5208263A Anti-androgen compounds 失效
标题翻译：抗雄虫化合物
公开(公告)号：US5208263A
公开(公告)日：1993-05-04
申请号：US413249
申请日：1989-09-27
申请人： Shutsung Liao , John Pataki , Ronald G. Harvey
发明人： Shutsung Liao , John Pataki , Ronald G. Harvey
IPC分类号： G01N33/50 , A61K31/00 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , A61K31/565 , A61P5/26 , C07C22/04 , C07C33/18 , C07C35/42 , C07C35/44 , C07C39/12 , C07C39/17 , C07C45/51 , C07C49/115 , C07C49/225 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07C69/00 , C07J1/00 , C07J63/00
CPC分类号： C07J63/008 , A61K31/045 , A61K31/05 , A61K31/12 , A61K31/22 , C07C39/17 , C07C45/513 , C07C45/516 , C07C49/657 , C07C49/665 , C07C49/747 , C07C49/753 , C07C49/792 , C07J1/0055 , C07J1/0059 , C07J1/007 , C07J1/0088 , C07C2103/26
摘要： Disclosed are novel classes of anti-androgen including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.

30. 发明授权

US5188759A Haloacetylene derivatives 失效
标题翻译：甲基乙烯衍生物
公开(公告)号：US5188759A
公开(公告)日：1993-02-23
申请号：US648627
申请日：1991-02-01
申请人： Ekkehard Bartmann , Reinhard Hittich , Herbert Plach , Ulrich Finkenzeller
发明人： Ekkehard Bartmann , Reinhard Hittich , Herbert Plach , Ulrich Finkenzeller
IPC分类号： C07C22/00 , C07C22/04 , C07C22/08 , C09K19/04 , C09K19/20 , C09K19/30 , C09K19/32 , C09K19/34 , C09K19/52 , C07C69/76
CPC分类号： C09K19/2007 , C07C22/00 , C07C22/04 , C07C22/08 , C09K19/04 , C09K19/30 , C09K19/3003 , C09K19/3098 , C09K19/321 , C09K19/3441 , C07C2101/14
摘要： The invention relates to a liquid crystalline medium having at least two components, where at least one component is a haloacetylene derivatives of the formula IR.sup.1 --A.sup.1 --Z.sup.1 --(A.sup.2 --Z.sup.2).sub.m --A.sup.3 --C.tbd.C--X IwhereinR.sup.1 is an alkyl or alkenyl radical having up to 15 carbon atoms which is unsubstituted or monosubstituted by CN, halogen or CF.sub.3, or such a radical wherein one or more CH.sub.2 groups is replaced, in each case independently of one another, by --S--, --O--, ##STR1## --CO--, --CO--O--, --O--CO-- or --O--CO--O-- in such a manner that sulfur and/or oxygen atoms are not linked directly to one another,A.sup.1, A.sup.2 and A.sup.3, in each case independently of one another, are(a) a trans-1,4-cyclohexylene radical or --S-- one or more non-adjacent CH.sub.2 groups is replaced by --O-- and/or --S--,(b) a 1,4-phenyllene radical N" in which one or two CH groups is replaced by N,(c) 1,3-cyclobutylene, 1,3-bicyclo(1,1,1)pentylene, 1,4-cyclohexenylene, 1,4-bicyclo(2,2,2)octylene, naphthalene-2,6-diyl, decahydronaphthalene-2,6-diyl and 1,2,3,4-tetrahydronaphthalene-2,6-diyl,Z.sup.1 and Z.sup.2 independently of one another, are --CH.sub.2 CH.sub.2 --, --C.dbd.C--, --CH.sub.2 O--, --OCH.sub.2 --, --CO--O--, --O--CO--, --CH.dbd.N--, --N.dbd.CH--, --CH.sub.2 S--, --SCH.sub.2 --, a single bond or an alkylene group having 3 to 6 carbon atoms in which one CH.sub.2 group may be replaced by --O--, --CO--O--, --O--CO--, --CH halogen-- or --CHCN--,X is F, Cl, --NCS, Br, --OCF.sub.3 or --SCF.sub.3, andm is 0, 1 or 2.
摘要翻译：本发明涉及具有至少两种组分的液晶介质，其中至少一种组分是式I的卤代乙炔衍生物R1-A1-Z1-（A2-Z2）m-A3-C 3BOND CX I其中R1是具有至多15个碳原子的烷基或链烯基，其被未取代的或被CN，卤素或CF 3单取代，或者其中一个或多个CH 2基团在每种情况下彼此独立地被-S-，-O - ， - ， - CO - ， - CO-O-，-O-CO-或-O-CO-O-，使得硫和/或氧原子彼此不直接连接，A1，A2 和A3各自独立地为（a）反式-1,4-亚环己基或-S-一个或多个不相邻的CH 2基团被-O-和/或-S-取代，（ b）其中一个或两个CH基团被N，（c）1,3-环丁烯，1,3-二环（1,1,1）亚戊基，1,4 - 环己烯，1,4-二环（2,2,2）亚辛基，萘-2,6-二基，十氢萘-2,6-二基和1,2,3,4 四氢萘-2,6-二基，Z 1和Z 2彼此独立地是-CH 2 CH 2 - ， - C = C - ， - CH 2 O - ， - OCH 2 - ， - CO-O-，-O-CO-， - CH = N，-N = CH-，-CH 2 S-，-SCH 2 - ，单键或碳原子数3〜6的亚烷基，其中一个CH 2基可以被-O - ， - CO-O-， -O-CO-，-CH-或-CHCN-，X是F，Cl，-NCS，Br，-OCF3或-SCF3，m是0,1或2。

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