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51. 发明授权

US4719047A Anthracene derivatives 失效
标题翻译：蒽衍生物
公开(公告)号：US4719047A
公开(公告)日：1988-01-12
申请号：US725157
申请日：1985-04-22
申请人： Kenneth W. Bair
发明人： Kenneth W. Bair
IPC分类号： C07D295/08 , A61K31/045 , A61K31/135 , A61K31/255 , A61K31/275 , A61K31/415 , A61K31/42 , A61K31/535 , A61K31/5375 , A61P31/00 , A61P35/00 , B01J27/135 , C07B61/00 , C07C29/147 , C07C33/46 , C07C63/44 , C07C63/70 , C07C66/02 , C07C67/00 , C07C69/76 , C07C205/15 , C07C213/00 , C07C213/02 , C07C215/06 , C07C215/08 , C07C215/10 , C07C215/20 , C07C215/28 , C07C215/38 , C07C215/42 , C07C215/44 , C07C217/48 , C07C217/58 , C07C253/00 , C07C255/56 , C07C255/58 , C07C313/00 , C07C315/04 , C07C317/32 , C07C317/36 , C07C319/20 , C07C323/32 , C07C323/36 , C07C323/38 , C07D213/02 , C07D233/61 , C07D263/52 , C07D263/62 , C07D263/64 , C07D295/10 , C07D295/12 , C07D295/135 , C07D309/12 , C07D317/32 , C07D319/06 , C07D498/04 , C07D521/00 , C07J63/00 , C07C93/00 , C07C87/28 , C07C87/64
CPC分类号： A61K31/045 , C07C205/15 , C07C215/10 , C07C215/28 , C07C215/42 , C07C217/48 , C07C217/58 , C07C255/58 , C07C317/32 , C07C323/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/52 , C07D263/64 , C07D295/135 , C07D309/12 , C07D319/06 , C07J63/008 , C07C2101/14 , C07C2103/24 , C07C2103/26 , C07C2103/40 , C07C2103/42 , C07C2103/48 , C07C2103/50 , Y10S514/908
摘要： The present invention relates to compounds of formula (I) ##STR1## wherein Ar is an anthracene or substituted anthracene ring system;R.sup.1 is a C.sub.1-3 alkylene moiety;R.sup.2 is hydrogen or a C.sub.1-6 alkyl group;R.sup.3 is a hydroxy C.sub.1-6 alkyl group;R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxy acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ;Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.

52. 发明授权

US4617141A Trans-4-alkyloxymethyl-1-(4'-substituted biphenylyl-4)cyclohexanes 失效
标题翻译：反式-4-烷氧基甲基-1-（4'-取代的联苯基-4-）环己烷
公开(公告)号：US4617141A
公开(公告)日：1986-10-14
申请号：US712752
申请日：1985-03-18
申请人： Hiromichi Inoue , Takashi Inukai , Yasuyuki Goto , Hideo Sato , Masahiro Fukui
发明人： Hiromichi Inoue , Takashi Inukai , Yasuyuki Goto , Hideo Sato , Masahiro Fukui
IPC分类号： C07C29/147 , C07C31/135 , C07C41/00 , C07C43/168 , C07C43/174 , C07C43/176 , C07C67/00 , C09K19/30 , G02F1/13 , G09F9/00 , C09K3/34
CPC分类号： C09K19/3003 , C07C29/147 , C07C31/1355 , C07C43/168 , C07C43/1747 , C07C43/176 , C09K2019/3021
摘要： Novel liquid crystal compounds having a higher clearing point and a superior stability are provided, which are trans-4-alkyloxymethyl-1-(4'-substituted biphenylyl-4)cyclohexanes expressed by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each represent an alkyl group of 1 to 8 cabon atoms and n represents 0 or 1.

53. 发明授权

US4550981A Liquid crystalline esters and mixtures 失效
标题翻译：液晶酯和混合物
公开(公告)号：US4550981A
公开(公告)日：1985-11-05
申请号：US530830
申请日：1983-09-09
申请人： Martin Petrzilka , Martin Schadt , Alois Villiger
发明人： Martin Petrzilka , Martin Schadt , Alois Villiger
IPC分类号： C07C29/147 , C07C31/135 , C07C61/12 , C07C61/39 , C07C63/49 , C07C63/72 , C07C69/773 , C07C69/90 , C07C205/39 , C07C205/43 , C07C255/34 , C07C255/50 , C07C255/51 , C09K19/00 , C09K19/20 , C09K19/30 , G02F1/13 , C07C79/26 , C07C121/52
CPC分类号： C07C255/00 , C07C205/43 , C07C29/147 , C07C309/00 , C07C31/1355 , C07C61/12 , C07C61/39 , C07C63/49 , C07C63/72 , C09K19/2007 , C09K19/3068 , C07B2200/09 , C07C2101/14
摘要： Compounds of the formula ##STR1## wherein X.sup.2 is a single covalent bond or --COO--; X.sup.1 is a single covalent bond, --COO--, --CH.sub.2 CH.sub.2 -- or when X.sup.2 is --COO--, X.sup.1 also can be p--C.sub.6 H.sub.4 --, p--C.sub.6 H.sub.4 --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 --p--C.sub.6 H.sub.4, p--C.sub.6 H.sub.4 --COO-- or --COO--p--C.sub.6 H.sub.4 ; ring A is a benzene ring or trans-1,4-cyclohexylene; ring B is a benzene ring or when X.sup.2 is --COO-- and X.sup.1 is a single covalent bond, --COO-- or --CH.sub.2 CH.sub.2 --, ring B also can be trans-1,4-cyclohexylene; Z.sup.1, Z.sup.2 and Z.sup.3 individually are hydrogen or when positioned on a benzene ring which is not linked directly with a further ring via a single covalent bond, Z.sup.1, Z.sup.2 and Z.sup.3 also can be halogen, cyano or methyl; Y.sup.2 is cyano, nitro, 2,2-dicyanovinyl or when Y.sup.1 is hydrogen Y.sup.2 also can be 2,2-dicyano-1-methylvinyl; Y.sup.1 is halogen, cyano, C.sub.1 -C.sub.3 -alkyl or, when X.sup.1 includes a benzene ring or --COO-- or Y.sup.2 is nitro or at least one of Z.sup.1 and Z.sup.2 is other than hydrogen, Y.sup.1 also can be hydrogen; and R.sup.1 is C.sub.1 -C.sub.12 -alkyl or when positioned on a benzene ring R.sup.1 also can be C.sub.1 -C.sub.12 -alkoxy, their manufacture and use in liquid crystalline mixtures are described.
摘要翻译：其中X 2是单个共价键或-COO-; X 1是单个共价键，-COO - ， - CH 2 CH 2 - 或当X 2是-COO-时，X 1也可以是对-C 6 H 4 - ，p-C 6 H 4 -CH 2 CH 2 - ， - CH 2 CH 2-p-C 6 H 4，p-C 6 H 4 -CO 2 - 或-COO-p-C6H4; 环A是苯环或反式-1,4-亚环己基; 环B为苯环，或者当X2为-COO-且X1为单一共价键时，可以为-COO-或-CH2CH2-，环B也可为反式-1,4-亚环己基; Z1，Z2和Z3分别为氢或当位于不与另一个环通过单个共价键直接连接的苯环上时，Z 1，Z 2和Z 3也可以是卤素，氰基或甲基; Y2是氰基，硝基，2,2-二氰基乙烯基或当Y1是氢时，Y2也可以是2,2-二氰基-1-甲基乙烯基; Y1是卤素，氰基，C1-C3-烷基，或当X1包括苯环或-COO-或Y2是硝基或Z1和Z2中的至少一个不是氢时，Y1也可以是氢; R1为C1-C12烷基，或者当位于苯环R1上时，也可以是C1-C12-烷氧基，它们在液晶混合物中的制备和应用被描述。

54. 发明授权

US4482568A Inhibition of alcohol metabolism by tetramethylene sulfoxides 失效
标题翻译：通过四亚甲基亚砜抑制酒精代谢
公开(公告)号：US4482568A
公开(公告)日：1984-11-13
申请号：US542482
申请日：1983-10-17
申请人： Bryce V. Plapp , Vijay K. Chadha
发明人： Bryce V. Plapp , Vijay K. Chadha
IPC分类号： C07C29/147 , C07C31/20 , C07D333/08 , C07D333/48 , A61K31/38 , C07D333/00
CPC分类号： C07D333/48 , C07C29/147 , C07C31/20 , C07D333/08
摘要： Tetramethylene sulfoxide and its substituted derivatives have been found to be exceptionally potent inhibitors of oxidation of alcohols by liver alcohol dehydrogenases.
摘要翻译：已经发现，四亚甲基亚砜及其取代的衍生物是由乙醇脱氢酶氧化醇的特别有效的抑制剂。

55. 发明授权

US4476106A Process for the extemporaneous preparation of an injectable fatty acid tagged in the omega position by means of radioactive iodine 失效
标题翻译：通过放射性碘临时制备在ω位置上标记的可注射脂肪酸的方法
公开(公告)号：US4476106A
公开(公告)日：1984-10-09
申请号：US392581
申请日：1982-06-28
申请人： Andre Bardy , Michel Comet , Sabine Coornaert , Jean-Paul Mathieu , Francoise Riche , Michel Vidal
发明人： Andre Bardy , Michel Comet , Sabine Coornaert , Jean-Paul Mathieu , Francoise Riche , Michel Vidal
IPC分类号： A61K51/00 , A61K51/04 , C07B59/00 , C07C29/147 , C07C33/042 , C07C51/363 , C07C53/19 , C07C57/18 , C07C57/52 , C07C59/01 , C07C59/42 , A61K43/00 , A61K49/00
CPC分类号： C07C59/42 , A61K51/0402 , C07C29/147 , C07C33/042 , C07C53/19 , C07C57/18 , C07C57/52 , C07C59/01 , A61K2123/00
摘要： A process for the preparation of a fatty acid tagged with radioactive iodine, wherein a brominated or iodized fatty acid is reacted, preferably in the omega position, with radioactive iodide in the dry state or with an aqueous solution of radioactive iodide, in the presence of vehicling iodide, to exchange the bromine or iodine of such fatty acid for radioactive iodine.Application to use as radio-pharmaceutical products for studying cardiac metabolism troubles in human beings by scintigraphy.
摘要翻译：制备用放射性碘标记的脂肪酸的方法，其中溴化或碘化脂肪酸优选在ω位置与放射性碘化物在干燥状态下或与放射性碘的水溶液在存在下反应交换碘化物，以将这种脂肪酸的溴或碘交换为放射性碘。应用于放射医药产品，用于通过闪烁扫描法研究人类的心脏代谢紊乱。

56. 发明授权

US4443449A Arylcyclobutylalkylamines and anti-depression composition and methods using same 失效
标题翻译：芳基丁基烷基胺和抗抑郁组合物及其使用方法
公开(公告)号：US4443449A
公开(公告)日：1984-04-17
申请号：US365287
申请日：1982-04-05
申请人： James E. Jeffery , Eric C. Wilmshurst
发明人： James E. Jeffery , Eric C. Wilmshurst
IPC分类号： A61K31/13 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/44 , C07C57/46 , C07C61/40 , C07D211/70 , C07D295/073 , C07D295/185 , A61K31/135 , C07C87/28
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/44 , C07C57/46 , C07C61/40 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, or C.sub.1-3 alkyl (with the proviso that R.sub.5 and R.sub.6 cannot both be H or methyl) or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring and R.sub.7 and/or R.sub.8 are H or C.sub.1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：其中R 1是H或C 1-3烷基的式I化合物 R2是H或C1-3烷基; R 3和/或R 4是H，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3或C 1-3烷基（条件是R 5和R 6不能都是H或甲基）或R 5和R 6与它们所连接的碳原子一起形成第二个苯 R 7和/或R 8为H或C 1-3烷基表示治疗抑郁症的治疗活性。公开了制备式I化合物的药物组合物和方法。

57. 发明授权

US4436662A Pyrrolo[3,4-d][2]benzazepinones 失效
标题翻译：吡咯并[3,4-d] [2]苯并氮杂
公开(公告)号：US4436662A
公开(公告)日：1984-03-13
申请号：US481021
申请日：1983-03-31
申请人： Rodney I. Fryer , Eugene J. Trybulski , Armin Walser
发明人： Rodney I. Fryer , Eugene J. Trybulski , Armin Walser
IPC分类号： C07C29/147 , C07C45/30 , C07C51/347 , C07D207/34 , C07D209/94 , C07D487/04 , C07D487/02
CPC分类号： C07D487/04 , C07C255/00 , C07C29/147 , C07C45/305 , C07C51/347 , C07D207/34 , C07D209/94
摘要： The present invention relates to compounds of the formula ##STR1## wherein R.sub.1 and R.sub.3 are selected from the group consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy or acyloxy and R.sub.2 and R.sub.4 are hydrogen or R.sub.1 and R.sub.2 and/or R.sub.3 and R.sub.4 taken together are oxo groups with the proviso that at least one oxo group is present; R is selected from the group consisting of hydrogen, lower alkyl, C.sub.2 to C.sub.7 carboxylic acids and the esters and amides thereof, hydroxy C.sub.2 to C.sub.7 alkyl and amino C.sub.2 to C.sub.7 alkyl or mono- or di-lower alkyl amino C.sub.2 to C.sub.7 alkyl; R.sub.5 is halogen or hydrogen; and R.sub.6 is halogen with the proviso that when R.sub.1 or R.sub.3 is hydroxy, lower alkoxy or acyloxy, then R is lower alkyl or hydrogen and the N-oxides and the pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及下式化合物：其中R1和R3选自氢，低级烷基，羟基，低级烷氧基或酰氧基，R2和R4是氢或R1，R2和/或R3和R4 一起是氧基，条件是存在至少一个氧代基团; R选自氢，低级烷基，C 2至C 7羧酸及其酯和酰胺，羟基C 2至C 7烷基和氨基C 2至C 7烷基或单 - 或二 - 低级烷基氨基C 2至C 7烷基; R5是卤素或氢; 并且R 6为卤素，条件是当R 1或R 3为羟基，低级烷氧基或酰氧基时，则R为低级烷基或氢，以及其N-氧化物及其药学上可接受的盐。

58. 发明授权

US4427614A 3-Hydroxybutyric acid polymers 失效
标题翻译： 3-羟基丁酸聚合物
公开(公告)号：US4427614A
公开(公告)日：1984-01-24
申请号：US434229
申请日：1982-10-14
申请人： Peter J. Barham , Paul A. Holmes
发明人： Peter J. Barham , Paul A. Holmes
IPC分类号： C07C17/16 , C07C29/147 , C07C45/30 , C07C405/00 , C07D267/10 , C07D295/096 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/62 , D01D5/12
CPC分类号： C07D295/096 , C07C17/16 , C07C29/147 , C07C405/00 , C07C405/0033 , C07C405/0041 , C07C45/30 , C07D267/10 , C07D295/112 , C07D295/155 , C07D307/935 , C07D309/12 , C07D311/00 , C07D333/12 , C07D333/16 , C07D333/22 , C07D333/24 , D01F6/625 , Y10S428/91
摘要： A solvent-free preform of a 3-hydroxybutyric acid polymer is subjected to a compression step to reduce its thickness by at least 5% and the compressed preform is then drawn uni- or bi- axially to induce orientation.
摘要翻译：将不含溶剂的3-羟基丁酸聚合物的预成型体进行压缩步骤以将其厚度减小至少5％，然后将压缩的预成型件单向或双向拉伸以诱导取向。

59. 发明授权

US4402973A Insecticidal (1,1'-biphenyl)-3-ylmethyl esters 失效
标题翻译：杀虫剂（1,1'-联苯）-3-基甲酯
公开(公告)号：US4402973A
公开(公告)日：1983-09-06
申请号：US265940
申请日：1981-05-21
申请人： Ernest L. Plummer
发明人： Ernest L. Plummer
IPC分类号： A01N37/10 , A01N37/44 , A01N53/00 , A01N53/06 , A01N53/10 , C07C17/093 , C07C17/14 , C07C17/26 , C07C22/04 , C07C29/09 , C07C29/128 , C07C29/147 , C07C29/32 , C07C29/40 , C07C29/62 , C07C33/24 , C07C33/46 , C07C35/50 , C07C45/56 , C07C63/331 , C07C63/72 , C07C69/157 , C07C69/74 , C07C69/743 , C07C69/753 , C07C205/06 , C07C205/12 , C07C205/19 , C07C205/42 , C07C205/57 , C07D263/10 , C07C69/747
CPC分类号： C07D263/10 , A01N37/10 , A01N53/00 , C07C17/093 , C07C17/14 , C07C17/26 , C07C205/06 , C07C205/12 , C07C205/19 , C07C205/42 , C07C205/57 , C07C22/04 , C07C29/095 , C07C29/1285 , C07C29/147 , C07C29/32 , C07C29/40 , C07C29/62 , C07C309/00 , C07C33/24 , C07C33/46 , C07C35/50 , C07C45/56 , C07C45/565 , C07C63/331 , C07C63/72 , C07C2101/14 , C07C2101/16
摘要： [1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.
摘要翻译： [1,1'-联苯] -3-基甲基拟除虫菊酯，以及其工艺，用途和中间体。 [1,1'-联苯] -3-基甲基拟除虫菊酯控制广谱的昆虫以及螨类。

60. 发明授权

US4386033A Process for the continuous thermal cleavage of carbamic acid esters and preparation of isocyanates from the products thereof 失效
标题翻译：用于连续热裂解氨基甲酸酯的方法和由其产物制备异氰酸酯
公开(公告)号：US4386033A
公开(公告)日：1983-05-31
申请号：US331412
申请日：1981-12-16
申请人： Klaus Konig , Peter Heitkamper
发明人： Klaus Konig , Peter Heitkamper
IPC分类号： B01J23/06 , B01J27/08 , B01J31/02 , B01J31/04 , B01J31/12 , C07B61/00 , C07C27/00 , C07C29/00 , C07C29/147 , C07C31/02 , C07C31/13 , C07C33/18 , C07C35/02 , C07C37/00 , C07C67/00 , C07C241/00 , C07C263/04 , C07C263/12 , C07C265/00 , C07C265/04 , C07C265/06 , C07C265/10 , C07C265/12 , C07C271/06 , C07C118/00
CPC分类号： C07C263/04 , C07C2101/14 , Y02P20/582
摘要： A carbamic acid ester corresponding to the formula R.sup.1 --NH--CO--OR.sup.2 is thermally cleaved to form isocyanate R.sup.1 --NCO and alcohol R.sup.2 --OH fractions. This cleavage is accomplished by boiling the carbamic acid ester, condensing the vapor given off in a first fractionation column, and condensing the vapor from the first fractionation column in a second fractionation column. The boiling of the carbamic acid ester is carried out in a manner such that the average dwell time in the reaction vessel is from 1 to 20 hours, the temperature is from 160.degree. to 260.degree. C. and the pressure is from 0.001 to 2 bar. The isocyanate fraction obtained by this cleavage process may be used as a starting material for a transurethanation reaction in which a lower boiling isocyanate R.sup.3 --NCO is produced. The radicals R.sup.1, R.sup.2, and R.sup.3 are defined herein.
摘要翻译：将对应于式R 1 -NH-CO-OR 2的氨基甲酸酯热裂解形成异氰酸酯R 1 -NCO和醇R 2 -OH部分。该裂解是通过沸腾氨基甲酸酯，将在第一分馏塔中排出的蒸气冷凝，并在第二分馏塔中将来自第一分馏塔的蒸气冷凝来完成的。氨基甲酸酯的沸腾以使得反应容器中的平均停留时间为1〜20小时，温度为160〜260℃，压力为0.001〜2巴的方式进行。通过该裂解方法得到的异氰酸酯部分可以用作产生低沸点异氰酸酯R 3 -NCO的经反氨化反应的原料。基团R 1，R 2和R 3在本文中定义。

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