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1. 发明公开

US20230302420A1 SCALE-UP OF MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：US20230302420A1
公开(公告)日：2023-09-28
申请号：US17978304
申请日：2022-11-01
申请人： President and Fellows of Harvard College
发明人： David A. Weitz , Mark Romanowsky , Adam R. Abate
IPC分类号： B01F33/3011 , B01L3/00 , B01F23/41 , B01J19/00
CPC分类号： B01F33/3011 , B01L3/502784 , B01F23/41 , B01F23/4105 , B01J19/0093 , Y10T137/8593 , B01J2219/00015 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01J2219/00975 , B01F2101/23
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

2. 发明申请

US20170181979A1 PROCESS FOR PRODUCING NANOPARTICLES 审中-公开
公开(公告)号：US20170181979A1
公开(公告)日：2017-06-29
申请号：US15300492
申请日：2015-03-25
申请人： SHIMADZU CORPORATION
发明人： Takashi KAWABE , Eiichi OZEKI
IPC分类号： A61K9/51 , A61K51/12 , C08G69/44 , A61K49/12 , A61K51/06 , C08J3/12 , B01J19/00 , A61K49/18
CPC分类号： A61K9/5192 , A61K9/5153 , A61K49/126 , A61K49/1824 , A61K51/06 , A61K51/1262 , B01J19/0093 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00903 , B01J2219/00954 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B82Y5/00 , B82Y40/00 , C08G69/44 , C08J3/07 , C08J3/12 , C08J2353/00 , C08J2377/12
摘要： Provided is a method for producing a nanoparticle having a uniform particle diameter. A method for producing a nanoparticle comprising an amphiphilic block polymer, the method comprising: with use of a nanoparticle production device that includes: a polymer solution supply channel Cp; an aqueous liquid supply channel Cw1, Cw2; a junction J of the channels; a nanoparticle formation channel Cn; and a nanoparticle-containing liquid outlet On, supplying a solution of a polymer and an aqueous liquid to the junction J; forming a nanoparticle while bringing a laminar flow of the polymer solution and a laminar flow of the aqueous liquid into contact with each other; obtaining a liquid containing the formed nanoparticle from the nanoparticle-containing liquid outlet; and controlling a particle diameter of the nanoparticle by measuring a statistic of the particle diameter of the formed nanoparticle in real time, and by controlling at least one of an amount of the polymer solution supplied to the junction and an amount of the aqueous liquid supplied to the junction such that the statistic becomes a desired value.

3. 发明授权

US09592555B2 Continuous flow reactor for the synthesis of nanoparticles 有权
标题翻译：用于合成纳米粒子的连续流动反应器
公开(公告)号：US09592555B2
公开(公告)日：2017-03-14
申请号：US14214587
申请日：2014-03-14
申请人： Shoei Electronic Materials, Inc.
发明人： David M. Schut , Thomas E. Novet , George M. Williams
IPC分类号： B01J19/12 , C09K11/56 , C09K11/88 , B22F9/16 , C01G21/21 , B22F1/00 , B22F1/02 , B22F9/24 , C01B19/00
CPC分类号： B22F9/16 , B01J19/0093 , B01J2219/00795 , B01J2219/0086 , B01J2219/00869 , B01J2219/00873 , B01J2219/00882 , B01J2219/00889 , B01J2219/00903 , B01J2219/00934 , B01J2219/00941 , B01J2219/00957 , B01J2219/0097 , B22F1/0018 , B22F1/0062 , B22F1/02 , B22F9/24 , B22F2999/00 , C01B19/002 , C01G21/21 , C01P2004/03 , B22F2202/11
摘要： A continuous flow reactor for the efficient synthesis of nanoparticles with a high degree of crystallinity, uniform particle size, and homogenous stoichiometry throughout the crystal is described. Disclosed embodiments include a flow reactor with an energy source for rapid nucleation of the procurors following by a separate heating source for growing the nucleates. Segmented flow may be provided to facilitate mixing and uniform energy absorption of the precursors, and post production quality testing in communication with a control system allow automatic real-time adjustment of the production parameters. The nucleation energy source can be monomodal, multimodal, or multivariable frequency microwave energy and tuned to allow different precursors to nucleate at substantially the same time thereby resulting in a substantially homogenous nanoparticle. A shell application system may also be provided to allow one or more shell layers to be formed onto each nanoparticle.
摘要翻译：描述了在整个晶体中高效合成具有高结晶度，均匀粒径和均匀化学计量的纳米颗粒的连续流动反应器。公开的实施方案包括具有用于快速成核的能量源的流动反应器，后者是用于生长成核的单独的加热源。可以提供分段流动以促进前体的混合和均匀的能量吸收，并且与控制系统通信的后期生产质量测试允许生产参数的自动实时调整。成核能源可以是单峰，多峰或多变量微波能量，并且被调整以允许不同的前体在基本相同的时间成核，从而导致基本上均匀的纳米颗粒。还可以提供壳应用系统以允许在每个纳米颗粒上形成一个或多个壳层。

4. 发明授权

US09566558B2 Device for manipulation of packets in micro-containers, in particular in microchannels 有权
标题翻译：用于操纵微型容器中的包装的装置，特别是在微通道中
公开(公告)号：US09566558B2
公开(公告)日：2017-02-14
申请号：US11662362
申请日：2005-09-09
申请人： Jean-Louis Viovy , Max Chabert , Kevin Dorfman
发明人： Jean-Louis Viovy , Max Chabert , Kevin Dorfman
IPC分类号： C12M1/00 , C12Q1/68 , C02F1/40 , G01N15/06 , G01N33/48 , G01N27/00 , B01F13/00 , B01J19/00 , B01L3/00 , F04B19/00 , G01N35/08 , B01L7/00 , G01N15/00 , G01N35/10
CPC分类号： B01L3/502784 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01L3/5027 , B01L3/502723 , B01L7/525 , B01L2200/0605 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0838 , B01L2300/1816 , B01L2300/1827 , B01L2300/1894 , B01L2400/0415 , B01L2400/0427 , B01L2400/0493 , C12Q1/686 , F04B19/006 , G01N35/08 , G01N2015/003 , G01N2015/0053 , G01N2035/1037
摘要： The present invention concerns a microfluidic device (1) for performing physical, chemical or biological treatment to at least one packet without contamination.
摘要翻译：本发明涉及用于对至少一个包进行物理，化学或生物处理而不被污染的微流体装置（1）。

5. 发明授权

US09486757B2 Scale-up of microfluidic devices 有权
标题翻译：微流体装置放大
公开(公告)号：US09486757B2
公开(公告)日：2016-11-08
申请号：US14710223
申请日：2015-05-12
申请人： President and Fellows of Harvard College
发明人： Mark Romanowsky , Adam R. Abate , David A. Weitz
IPC分类号： G01N1/10 , B01L3/00 , B01F13/00 , B01F3/08 , B01J19/00
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F2215/0037 , B01J19/0093 , B01J2219/00015 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , B01J2219/00975 , B01L3/502784 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , Y10T137/0318 , Y10T137/8593
摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.
摘要翻译：描述了用于在流体中聚焦和/或形成相似或不同尺寸的不连续部分的微流体方法和装置的并行使用。在一些方面，本发明一般涉及流动聚焦型技术，还涉及微流体，更具体地说，并行使用布置成控制分散剂内的分散相的微流体系统，以及尺寸和尺寸分布分散相在多相流体系统中，以及用于将流体组分输送到多个这样的装置的系统。

6. 发明授权

US09446360B2 Microfluidic system and methods for highly selective droplet fusion 有权
标题翻译：微流控系统和高选择性液滴融合方法
公开(公告)号：US09446360B2
公开(公告)日：2016-09-20
申请号：US13319180
申请日：2010-05-07
申请人： Linas Mazutis
发明人： Linas Mazutis
IPC分类号： B01F5/06 , B01F3/08 , B01F13/00 , B01J19/00 , B01L3/00
CPC分类号： B01F5/0646 , B01F3/0807 , B01F5/0647 , B01F13/0062 , B01F13/0071 , B01J19/0093 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/00909 , B01J2219/0097 , B01L3/502769 , Y10T137/0318
摘要： A method and chip for fusing droplets in a chip comprising (i) providing a first set of droplets which are partially or not stabilized by surfactant, (ii) providing a second set of droplets which are stabilized by surfactant, (iii) contacting each droplet of the first set with single or multiple droplets of the second set in a pairing module and (iv) fusing droplets of the first set with droplets of the second set through a droplet fusion module in which the droplets experience at least one acceleration and/or deceleration and/or reorientation and/or rearrangement in space and time.
摘要翻译：一种用于在芯片中熔融液滴的方法和芯片，包括（i）提供部分或不由表面活性剂稳定的第一组液滴，（ii）提供由表面活性剂稳定的第二组液滴，（iii）使每个液滴所述第一组具有配对模块中的第二组的单个或多个液滴，以及（iv）通过液滴熔融模块将第一组液滴与第二组的液滴融合，其中液滴经历至少一个加速度和/或减速和/或重新定向和/或重新排列。

7. 发明申请

US20150073061A1 COATED MICROFLUIDIC DEVICES AND METHODS OF MAKING 有权
标题翻译：涂层微流体装置及其制备方法
公开(公告)号：US20150073061A1
公开(公告)日：2015-03-12
申请号：US14486290
申请日：2014-09-15
申请人： Cambridge Enterprise Limited
发明人： Wolfgang Andreas BAUER , Wilhelm T.S. HUCK , Martin FISCHLECHNER
IPC分类号： B01L3/00 , B01F17/00
CPC分类号： B01L3/502707 , B01F17/00 , B01J2219/00511 , B01J2219/0059 , B01J2219/00637 , B01J2219/00783 , B01J2219/00788 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0097 , B01L2200/0636 , B01L2300/0867 , B01L2300/16 , B01L2300/161 , B05C7/04 , B05D7/22 , B05D7/222 , B81B2201/0214 , B81B2201/05 , B81B2201/052 , B81B2201/058 , B81C1/00119 , B81C1/00206 , Y10T137/8593
摘要： We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.
摘要翻译：我们描述了将多层材料层逐层沉积到微流体装置的通道的壁或壁上的方法，该方法包括：将具有一系列溶液段的管装载，含有待沉积材料的溶液; 将所述管连接到所述微流体装置; 以及将所述溶液段注射到所述微流体装置中，使得所述溶液段又通过所述通道沉积连续的材料层，以在所述通道的所述壁或壁上执行所述逐层沉积。该方法的实施方案对于塑料的自动表面改性特别有用，例如PDMS（聚（二甲基硅氧烷）），微通道。我们还描述了形成双重乳液的方法和设备。

8. 发明授权

US08216525B2 Modular microfluidic system 有权
标题翻译：模块化微流体系统
公开(公告)号：US08216525B2
公开(公告)日：2012-07-10
申请号：US11992534
申请日：2006-09-26
申请人： Astrid Lohf , Reinhold Schneeberger , Robert Sendner
发明人： Astrid Lohf , Reinhold Schneeberger , Robert Sendner
IPC分类号： G01N1/38
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00867 , B01J2219/00871 , B01J2219/00873 , B01J2219/00891 , B01J2219/0097
摘要： A modular microfluidic system includes modules which are arranged next to each other in a row. Every module has a microfluidic part which rests on a contact surface of the module in a locally limited area and is forced against the contact surface by a fastening element. The microfluidic part includes a fluid channel system with fluid connections that are arranged on the top surface of the microfluidic part in edge areas relative to the adjoining microfluidic parts. The fluid connections of adjoining microfluidic parts are interlinked by respective connecting channels in a connecting part bridging the microfluidic parts, wherein the connecting part rests on the microfluidic parts in the edge areas. A clamping part rests against the lower surfaces of the adjoining microfluidic parts and is connected to the connecting part via an additional fastening element in the area between the microfluidic parts.
摘要翻译：模块化微流体系统包括彼此排列成一排的模块。每个模块都具有微流体部件，该微流体部件在局部有限的区域中位于模块的接触表面上，并且通过紧固元件被迫抵靠接触表面。微流体部件包括具有流体连接的流体通道系统，其相对于相邻的微流体部件布置在边缘区域中的微流体部件的顶表面上。邻接的微流体部件的流体连接通过桥接微流体部件的连接部分中的相应的连接通道相互连接，其中连接部分搁置在边缘区域中的微流体部件上。夹紧部件靠在邻接的微流体部件的下表面上，并且通过在微流体部件之间的区域中的附加紧固元件连接到连接部件。

9. 发明授权

US08029733B2 Thermal cycler with optical detector 有权
标题翻译：带光学探测器的热循环仪
公开(公告)号：US08029733B2
公开(公告)日：2011-10-04
申请号：US11981155
申请日：2007-10-30
申请人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
发明人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
IPC分类号： G01N21/00 , G01N21/01 , G01N21/62 , G01N21/63
CPC分类号： G01N21/75 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/505 , B01L3/508 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.
摘要翻译：具有用于保持样品的反应室的反应容器通过制造具有限定室的小壁的刚性框架的壳体来制造。壳体还限定了用于将流体引入腔室的端口。至少一个片或薄膜连接到刚性框架以形成腔室的至少一个主壁。在优选实施例中，两个片或膜连接到刚性框架的相对侧面以形成腔室的两个相对的主壁，主壁通过次壁彼此连接。

10. 发明申请

US20110097706A1 MICRO-REACTOR FOR OBSERVING PARTICLES IN A FLUID 有权
标题翻译：用于在流体中观察颗粒的微反应器
公开(公告)号：US20110097706A1
公开(公告)日：2011-04-28
申请号：US12912468
申请日：2010-10-26
申请人： Gerard Anne Nicolaas van Veen , Jacobus Peter Johannes Peters , Pleun Dona , Alan Frank De Jong
发明人： Gerard Anne Nicolaas van Veen , Jacobus Peter Johannes Peters , Pleun Dona , Alan Frank De Jong
IPC分类号： C12Q1/70 , G01N15/00 , G01N21/00 , C12M1/34 , G01N33/53 , G01N23/00 , G01N21/76 , G01N33/554 , G01N31/10
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00905 , B01J2219/0097 , B01L3/502761 , B01L7/54 , B01L2200/0668 , B01L2300/0822 , B01L2400/0415 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , G01N2021/058 , H01J37/20 , H01J37/26 , H01J2237/2004 , Y10T436/143333
摘要： The invention relates to a micro-reactor for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel formed between two layers for containing the fluid, with an inlet and an outlet, the two layers separated by a first distance. A likewise second channel with an inlet and an outlet is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 μm or less.The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc. A method of using the micro-reactor includes applying a gradient over the gap, thereby causing the particles to cross the gap. The gradient may be static or dynamic, and may be a gradient in concentration, of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field. By detecting a property of the particles upstream in the first channel, e.g. using fluorescent labels on the particles, and then applying a pressure burst over the channels when the property meets certain preset criteria, only selected particles can be placed in the gap.
摘要翻译：本发明涉及用于观察流体中的小颗粒，细胞，细菌，病毒或蛋白质分子的微反应器。微反应器示出了在两层之间形成的用于容纳流体的第一通道，具有入口和出口，两层分开第一距离。具有入口和出口的同样的第二通道被放置成与第一通道相邻。间隙连接第一通道和第二通道，在间隙处，至少一层显示对于检查方法是透明的窗口，并且在窗口处，两层被隔开非常小的距离，例如1μm或更小。微反应器可以与光学显微镜一起使用（其中所有颗粒都在焦点中），用扫描透射电子显微镜（其中电子的范围被限制）进行检查，在250- 500eV范围（也显示有限范围）等。使用微反应器的方法包括在间隙上施加梯度，从而使颗粒穿过间隙。梯度可以是静态或动态的，并且可以是化学或生物材料在压力，温度，电位或磁场中的浓度梯度。通过检测第一通道上游的颗粒的性质，例如，在颗粒上使用荧光标记，然后当性能达到某些预设标准时，在通道上施加压力突发，只有选定的颗粒才能放置在间隙中。

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