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    • 61. 发明授权
    • Collared hub pin for a tape cartridge
    • 磁带盒的卡圈式针脚
    • US6032895A
    • 2000-03-07
    • US219254
    • 1998-12-22
    • David A. KrulaTom KaoLi Zhao
    • David A. KrulaTom KaoLi Zhao
    • G03B23/02G11B20060101
    • G03B23/02
    • A tape cartridge has a baseplate surrounded by a housing. Two hub pins are disposed within the housing substantially perpendicular to the baseplate. Each pin has top and bottom portions and a collared portion therebetween. The bottom portion of each pin is press-fitted into a mating aperture in the baseplate with the collared portion bearing against the baseplate. A large diameter tape hub is rotatably mounted on the top portion. The collared portions allow the hub pins to withstand heavy side loads without significantly deflecting from the perpendicular. Two large diameter tape hubs are rotatably mounted around the hub pins and improve the empty hub to full pack diameter ratios, and improve the resulting tangential drive force and tape tension profiles as the tape moves between the hubs. A back set of belt rollers includes a high-drag roller that engages the drive belt at a fixed wrap angle and produces a relatively constant drag. A front set of belt rollers includes a drive roller and has rollers mounted to form substantially equal geometries with rollers in the back set relative to the tape hubs. The constant wrap angle of a drive belt on the high-drag roller tends to outweigh varying drags from other rollers, causing less change in tape tension and tangential drive force as the tape is transferred from hub to hub in response to movement of the drive belt along a path in contact with the drive roller, the belt rollers, and the tape on the hubs.
    • 磁带盒具有由壳体包围的基板。 两个毂销布置在壳体内基本垂直于底板。 每个销具有顶部和底部以及它们之间的套环部分。 每个销的底部被压配合到基板中的配合孔中,其中轴环部分抵靠基板。 大直径磁带轮毂可旋转地安装在顶部上。 轴环部分允许轮毂销承受重的侧向载荷,而不会明显地偏离垂直。 两个大直径的磁带轮毂可旋转地安装在轮毂销周围,并将空的轮毂改善成全包装直径比,并且随着带在轮毂之间移动而改善所产生的切向驱动力和带张力轮廓。 背面的一组皮带辊包括一个高牵引辊,它以固定的包角接合传动带并产生相对恒定的阻力。 前一组皮带辊包括驱动辊,并且具有安装的辊,以形成与后背组中的辊相对于带轮毂大致相等的几何形状。 驱动带在高牵引辊上的恒定包角倾向于超过其它辊的变化的拖动,从而当带根据传动带的移动将带从轮毂转移到轮毂时,带张力和切向驱动力的变化较小 沿着与驱动辊,带辊和轮毂上的带接触的路径。
    • 69. 发明申请
    • APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    • APO A-I MIME技术和治疗方法
    • US20110263497A1
    • 2011-10-27
    • US13177473
    • 2011-07-06
    • Katsuyuki MuraseLi ZhaoIrina AstafievaPaul M. Consigny
    • Katsuyuki MuraseLi ZhaoIrina AstafievaPaul M. Consigny
    • A61K38/10A61P9/10
    • A61K38/17A61K31/661A61K38/10A61K38/1709
    • A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
    • 一种方法,包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1(Apo A-I)模拟肽引入特定区域的血管壁,其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI(Apo AI)模拟肽或Apo AI合成肽和Acyl CoA胆固醇:酰基转移酶(ACAT)抑制剂的组合的组合物,其形式适于递送到血管中,所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物,其包含适于递送至血管的形式的载脂蛋白A-1(Apo AI)合成肽,所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体, Apo AI的螺旋9。