专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07692776B2 Chemical imaging explosives (CHIMED) optical sensor 有权
标题翻译：化学成像炸药（CHIMED）光学传感器
公开(公告)号：US07692776B2
公开(公告)日：2010-04-06
申请号：US11645132
申请日：2006-12-22
申请人： Patrick J. Treado , Matthew P. Nelson
发明人： Patrick J. Treado , Matthew P. Nelson
IPC分类号： G01N21/00
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01N21/6456 , G01N21/65 , G01N33/227 , G01N2001/024 , G01N2021/6417 , G01N2021/6484
摘要： A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.
摘要翻译：一种检测位于样品上的爆炸性化合物的系统和方法。用动物安全的紫外线辐射照射样品，产生荧光数据集。基于荧光数据集搜索荧光数据库，以识别已知的荧光数据集。如果荧光数据库的搜索识别已知荧光数据集，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样品中的感兴趣区域。用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据集。基于拉曼数据集搜索拉曼数据库，以便识别已知的拉曼数据集。基于通过搜索拉曼数据库识别的已知拉曼数据集来识别感兴趣区域中的爆炸性化合物。

2. 发明申请

US20070086003A1 Method for detection of pathogenic microorganisms 有权
公开(公告)号：US20070086003A1
公开(公告)日：2007-04-19
申请号：US11440845
申请日：2006-05-25
申请人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
发明人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
摘要： A method for the detection and identification of pathogenic microorganisms using Raman scattered light and transmitted light in the near infrared spectral region. The method may include passing the Raman scattered light and transmitted light through a FAST fiber array spectral translator.

3. 发明申请

US20070153268A1 System and method for classifying cells and the pharmaceutical treatment of such cells using Raman spectroscopy 有权
标题翻译：使用拉曼光谱分析细胞的系统和方法以及这种细胞的药物处理
公开(公告)号：US20070153268A1
公开(公告)日：2007-07-05
申请号：US11650378
申请日：2007-01-05
申请人： Janice Panza , John Maier , Jason Neiss
发明人： Janice Panza , John Maier , Jason Neiss
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/28 , G01J3/36 , G01N15/1475 , G01N21/65 , G01N2015/1006 , G01N2015/1488 , G01N2021/656
摘要： A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.
摘要翻译：将正常细胞与凋亡细胞区分开的系统和方法。选择预定矢量空间，其中矢量空间在数学上描述用于正常细胞的第一多个参考拉曼数据集和用于凋亡细胞的第二多个参考拉曼数据集。用基本上单色的光照射样品，产生基于散射光子的目标拉曼数据集。目标拉曼数据集被转换成由预定向量空间定义的向量空间。在预定向量空间中分析变换数据的分布。基于分析，样品被分类为含有正常细胞，凋亡细胞，以及正常细胞和凋亡细胞的组合。样品包括在照射样品之前用药剂处理样品的步骤。根据分类，评估药剂的治疗效果。

4. 发明授权

US07697576B2 Cytological analysis by raman spectroscopic imaging 有权
标题翻译：通过拉曼光谱成像进行细胞学分析
公开(公告)号：US07697576B2
公开(公告)日：2010-04-13
申请号：US11000591
申请日：2004-11-30
申请人： John S. Maier , Joseph E. Demuth , Jeffrey K. Cohen , Shona Stewart , Lindy A. McClelland
发明人： John S. Maier , Joseph E. Demuth , Jeffrey K. Cohen , Shona Stewart , Lindy A. McClelland
IPC分类号： H01S3/00
CPC分类号： A61B5/0084 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/4519 , G01N21/65
摘要： Raman molecular imaging is used to differentiate between normal and diseased cells or tissue. For instance benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view.
摘要翻译：拉曼分子成像用于区分正常和病变细胞或组织。例如，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾脏，乳腺和结肠，以及非上皮组织，如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。

5. 发明申请

US20070258089A1 Method and apparatus for chemical imaging in a microfluidic circuit 有权
标题翻译：用于在微流体电路中进行化学成像的方法和装置
公开(公告)号：US20070258089A1
公开(公告)日：2007-11-08
申请号：US11824878
申请日：2007-07-03
申请人： David Tuschel , Thomas Voigt
发明人： David Tuschel , Thomas Voigt
IPC分类号： G01J3/30
CPC分类号： G01N21/05 , B01L3/5027 , G01J3/0227 , G01J3/4406 , G01N21/03 , G01N21/31 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/0325 , G01N2021/0346 , G01N2021/651
摘要： The disclosure generally relates to a system for detecting a change in an attribute of a substance. The system may include a photon source for producing a first of a plurality of photons which interact with the substance while an attribute of the substance changes to produce a second plurality of photons. The system may also include a filter for receiving the collected photons and providing filtered photons; a photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the substance; and a processor for detecting an aspect of the filtered photons wherein the aspect of the filtered photons is the function of the attribute of the substance.
摘要翻译：本发明一般涉及用于检测物质属性变化的系统。该系统可以包括用于产生与物质相互作用的多个光子中的第一个的光子源，同时物质的属性改变以产生第二多个光子。该系统还可以包括用于接收所收集的光子并提供经滤光的光子的滤光器; 光子检测器，用于接收经滤光的光子并从中获得物质的光谱; 以及用于检测滤光光子的方面的处理器，其中滤光光子的方面是物质属性的函数。

6. 发明申请

US20070192035A1 Forensic integrated search technology 审中-公开
标题翻译：法医综合搜索技术
公开(公告)号：US20070192035A1
公开(公告)日：2007-08-16
申请号：US11450138
申请日：2006-06-09
申请人： Robert Schweitzer , Patrick Treado , Jason Neiss
发明人： Robert Schweitzer , Patrick Treado , Jason Neiss
IPC分类号： C40B30/02
CPC分类号： G06F16/2462 , G16C20/20 , G16C20/90
摘要： A system and method to search spectra databases and to identify unknown materials. A library having a plurality of sublibraries is provided wherein each sublibrary contains a plurality of reference data sets generated by a corresponding one of a plurality of spectroscopic data generating instruments associated with the sublibrary. Each reference data set characterizes a corresponding known material. A plurality of test data sets is provided that is characteristic of an unknown material, wherein each test data set is generated by one or more of the plurality of spectroscopic data generating instruments. For each test data set, each sublibrary is searched where the sublibrary is associated with the spectroscopic data generating instrument used to generate the test data set. A corresponding set of scores for each searched sublibrary is produced, wherein each score in the set of scores indicates a likelihood of a match between one of the plurality of reference data sets in the searched sublibrary and the test data set. A set of relative probability values is calculated for each searched sublibrary based on the set of scores for each searched sublibrary. All relative probability values for each searched sublibrary are fused producing a set of final probability values that are used in determining whether the unknown material is represented through a known material characterized in the library. A highest final probability value is selected from the set of final probability values and compared to a minimum confidence value. The known material represented in the libraries having the highest final probability value is reported, if the highest final probability value is greater than or equal to the minimum confidence value.
摘要翻译：搜索光谱数据库并识别未知材料的系统和方法。提供具有多个子图库的库，其中每个子图库包含由与该子图书馆相关联的多个光谱数据生成装置中的相应一个生成的多个参考数据集。每个参考数据集表征相应的已知材料。提供了许多测试数据集，其是未知材料的特征，其中每个测试数据集由多个光谱数据产生装置中的一个或多个产生。对于每个测试数据集，搜索每个子图书馆，其中子图书馆与用于生成测试数据集的光谱数据生成工具相关联。产生每个搜索的子图库的相应的一组分数，其中该分数集中的每个分数表示搜索的子图库中的多个参考数据集之一与测试数据集之间的匹配的可能性。基于每个搜索的子图库的分数集合，针对每个搜索的子图书馆计算一组相对概率值。每个搜索的子图库的所有相对概率值被融合，产生用于确定未知材料是否通过库中表征的已知材料表示的一组最终概率值。从最终概率值的集合中选择最高的最终概率值并与最小置信度值进行比较。如果最大最终概率值大于或等于最小置信度值，则报告具有最高最终概率值的库中表示的已知材料。

7. 发明申请

US20060253261A1 Digitizing biology 审中-公开
标题翻译：数字化生物学
公开(公告)号：US20060253261A1
公开(公告)日：2006-11-09
申请号：US11484040
申请日：2006-07-11
申请人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
发明人： John Maier , Patrick Treado , Jeffrey Cohen , Jason Neiss
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

8. 发明申请

US20060250613A1 Method and applications to enhance and image optical signals from biological objects 审中-公开
标题翻译：从生物对象增强和成像光信号的方法和应用
公开(公告)号：US20060250613A1
公开(公告)日：2006-11-09
申请号：US11404964
申请日：2006-04-14
申请人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
发明人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/32 , G01N21/658
摘要： A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.
摘要翻译：一种用于成像生物体的方法和装置。提供了具有均匀分布在表面上的增强结构的SERS表面。该表面包括至少5×10 5 nm的二维区域。增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。生物材料沉积在SERS表面上。使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。使用可调滤波器将拉曼散射光子滤波成多个预定波长带。二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

9. 发明授权

US07317526B2 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US07317526B2
公开(公告)日：2008-01-08
申请号：US11399032
申请日：2006-04-06
申请人： Thomas C. Voigt , David Tuschel , John S. Maier
发明人： Thomas C. Voigt , David Tuschel , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

10. 发明授权

US07268862B2 Near infrared chemical imaging microscope 有权
公开(公告)号：US07268862B2
公开(公告)日：2007-09-11
申请号：US11366887
申请日：2006-03-02
申请人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/00 , G01J3/40
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式