专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20150090873A1 Method of Single Point Internal Lock-Mobility Correction 有权
标题翻译：单点内锁移动校正方法
公开(公告)号：US20150090873A1
公开(公告)日：2015-04-02
申请号：US14123532
申请日：2012-06-01
申请人： Jeffery Mark Brown , Kevin Giles
发明人： Jeffery Mark Brown , Kevin Giles
IPC分类号： H01J49/00 , H01J49/26 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/26
摘要： A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions.
摘要翻译：公开了一种质谱法，其包括使离子通过离子迁移谱仪并获得第一离子迁移率漂移时间数据。将校准功能应用于第一离子迁移率漂移时间数据以确定离子的物理化学性质（例如CCS）。然后获取第二离子迁移率漂移时间数据，并且将校准功能应用于第二离子迁移率漂移时间数据，以确定一种或多种已知或参考离子的物理化学性质。

42. 发明授权

US08952323B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08952323B2
公开(公告)日：2015-02-10
申请号：US12092601
申请日：2006-11-10
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , G01N27/62 , H01J49/42
CPC分类号： H01J49/004 , G01N27/622 , H01J49/0031 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a first ion trap or ion guide (2), a single ion mobility spectrometer or separator stage (3) and a second ion trap or ion guide (4) arranged downstream of the ion mobility spectrometer or separator (3). In a mode of operation ions from the second ion trap or ion guide (4) are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator (3).
摘要翻译：公开了一种质谱仪，其包括第一离子阱或离子导向器（2），单离子迁移谱仪或分离器级（3）和设置在离子迁移谱仪或分离器（3）的下游的第二离子阱或离子导向器）。在操作模式中，来自第二离子阱或离子导向器（4）的离子从第二离子阱或离子导向器返回到离子迁移谱仪或分离器（3）的上游。

43. 发明授权

US08946626B2 Ion trap with spatially extended ion trapping region 有权
标题翻译：离子阱具有空间延伸的离子捕获区域
公开(公告)号：US08946626B2
公开(公告)日：2015-02-03
申请号：US14240667
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , B01D59/44
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译：公开了具有增加的电荷存储容量的质量或质量 - 电荷比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC电压和/或RF电压用于将离子限制在离子阱内的第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。离子在第三（z）方向上被激发，并且被导致在第三（z）方向上选择性地喷射的质量或质量 - 充电比。

44. 发明申请

US20140224974A1 Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US20140224974A1
公开(公告)日：2014-08-14
申请号：US14130428
申请日：2012-07-06
申请人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
发明人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。

45. 发明授权

US08519328B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08519328B2
公开(公告)日：2013-08-27
申请号：US13435877
申请日：2012-03-30
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose , Steven Derek Pringle
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap is disclosed having an entrance electrode and an exit electrode. The potential of the exit electrode is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap via an aperture in the exit electrode. The period of time that the potential of the exit electrode is dropped for is progressively increased and ions emerge from the ion guide or ion trap in a mass to charge ratio dependent manner. The ion guide or ion trap may be operated as a mass separator or low resolution mass analyzer.
摘要翻译：公开了一种具有入口电极和出射电极的离子导向器或离子阱。出口电极的电位周期性地下降相当短的时间段，允许一些离子通过出射电极的孔离开离子导向器或离子阱。出口电极的电位下降的时间段逐渐增加，并且离子导向器或离子阱以质荷比依赖的方式出现离子。离子导向器或离子阱可以作为质量分离器或低分辨率质量分析器来操作。

46. 发明授权

US08440968B2 Ion-mobility analyser 有权
标题翻译：离子迁移率分析仪
公开(公告)号：US08440968B2
公开(公告)日：2013-05-14
申请号：US13166882
申请日：2011-06-23
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/00
CPC分类号： G01N27/624
摘要： An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes, a plurality of axially segmented lower electrodes, a first plurality of axially segmented intermediate electrodes and a second plurality of axially segmented intermediate electrodes which together define an ion pathway. An asymmetric voltage waveform is applied to the upper electrodes and a DC compensating voltage is applied to the lower electrodes in order to separate ions in a vertical radial direction according to their rate of change of ion mobility with electric field strength. At the same time, a DC axial voltage gradient is maintained along the axial length of the analyser in order to separate ions axially according to their ion mobility.
摘要翻译：公开了一种离子迁移率分析仪，其包括多个轴向分段的上电极，多个轴向分段的下电极，第一多个轴向分段的中间电极和第二多个轴向分段的中间电极，这两个中间电极共同限定离子通路。对上部电极施加非对称电压波形，并且向下部电极施加直流补偿电压，以便根据其离子迁移率随电场强度的变化率在垂直方向上分离离子。同时，沿着分析仪的轴向长度保持直流轴向电压梯度，以便根据离子迁移率轴向分离离子。

47. 发明授权

US08426802B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08426802B2
公开(公告)日：2013-04-23
申请号：US12518291
申请日：2007-12-12
申请人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译：公开了一种质谱仪，其包括可在第一操作模式中操作的装置，其通过施加连续的轴向电场根据其离子迁移率暂时分离离子。该装置还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比暂时分离。

48. 发明申请

US20120018631A1 ION-MOBILITY ANALYSER 有权
标题翻译：离子能力分析仪
公开(公告)号：US20120018631A1
公开(公告)日：2012-01-26
申请号：US13166882
申请日：2011-06-23
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes 12a-12g, a plurality of axially segmented lower electrodes 13a-13g, a first plurality of axially segmented intermediate electrodes and a second plurality of axially segmented intermediate electrodes which together define an ion pathway. An asymmetric voltage waveform is applied to the upper electrodes 12a-12g and a DC compensating voltage is applied to the lower electrodes 13a-13g in order to separate ions in a vertical radial direction according to their rate of change of ion mobility with electric field strength. At the same time, a DC axial voltage gradient is maintained along the axial length of the analyser in order to separate ions axially according to their ion mobility.
摘要翻译：公开了一种离子迁移率分析仪，其包括多个轴向分段的上电极12a-12g，多个轴向分段的下电极13a-13g，第一多个轴向分段的中间电极和第二多个轴向分段的中间电极，离子途径。将不对称电压波形施加到上电极12a-12g，并且向下电极13a-13g施加DC补偿电压，以便根据其离子迁移率随电场强度的变化率在垂直方向上分离离子。同时，沿着分析仪的轴向长度保持直流轴向电压梯度，以便根据离子迁移率轴向分离离子。

49. 发明申请

US20110042565A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110042565A1
公开(公告)日：2011-02-24
申请号：US12917720
申请日：2010-11-02
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator 4 and an ion guide 6 arranged downstream of the ion mobility spectrometer or separator 4. A plurality of axial potential wells are created in the ion guide 6 so that ions received from the ion mobility spectrometer or separator 4 become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator 4. The potential wells are translated along the length of the ion guide 6.
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪或分离器4和布置在离子迁移谱仪或分离器4下游的离子导向器6.在离子导向器6中产生多个轴向势阱，使得从离子迁移率光谱仪或分离器4被限制在单独的轴向势阱中。势阱保持从离子迁移谱仪或分离器4接收的离子的保真度和/或组成。势阱沿离子导向器6的长度平移。

50. 发明授权

US07829841B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07829841B2
公开(公告)日：2010-11-09
申请号：US11718213
申请日：2005-11-03
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/06 , H01J49/26 , H01J49/40 , H01J49/42
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (4) and an ion guide (6) arranged downstream of the ion mobility spectrometer or separator (4). A plurality of axial potential wells are created in the ion guide (6) so that ions received from the ion mobility spectrometer or separator (4) become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator (4). The potential wells are translated along the length of the ion guide (6).
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪或分离器（4）和布置在离子迁移谱仪或分离器（4）的下游的离子导向器（6）。在离子导向器（6）中产生多个轴向势阱，使得从离子迁移谱仪或分离器（4）接收的离子被限制在单独的轴向势阱中。潜在的孔维持从离子迁移谱仪或分离器（4）接收的离子的保真度和/或组成。潜在的井沿离子导向件（6）的长度平移。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式