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51. 发明授权

US08164052B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08164052B2
公开(公告)日：2012-04-24
申请号：US12593006
申请日：2008-03-26
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。离子经验可忽略大部分的RF加热，捕集体积使分析物和试剂离子的动能降低到高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。

52. 发明申请

US20110303838A1 Method Of Avoiding Space Charge Saturation Effects In An Ion Trap 有权
标题翻译：在离子阱中避免空间电荷饱和效应的方法
公开(公告)号：US20110303838A1
公开(公告)日：2011-12-15
申请号：US12997347
申请日：2009-06-08
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer is provided comprising a first ion trap (2) arranged upstream of an analytical second ion trap (5). The charge capacity of the first ion trap (2) is set at a value such that if all the ions stored within the first ion trap (2) up to the charge capacity limit of the first ion trap (2) are then transferred to the second ion trap (5), then the analytical performance of the second ion trap (5) is not substantially degraded due to space charge effects.
摘要翻译：提供质谱仪，其包括布置在分析性第二离子阱（5）上游的第一离子阱（2）。将第一离子阱（2）的充电容量设定为使得如果存储在第一离子阱（2）内的所有离子直到第一离子阱（2）的充电容量极限，则转移到第二离子阱（5），则由于空间电荷效应，第二离子阱（5）的分析性能基本上不劣化。

53. 发明申请

US20100252730A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100252730A1
公开(公告)日：2010-10-07
申请号：US12668813
申请日：2008-07-14
申请人： Martin Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
发明人： Martin Green , Daniel James Kenny , David Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/02 , H01J49/26
CPC分类号： H01J49/4205 , H01J49/02 , H01J49/4225
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion trap (2, 3) wherein a potential field is created at the exit of the ion trap (4, 5) which decreases with increasing radius in one radial direction. Ions within the ion trap (2, 3) are mass selectively excited in a radial direction. Ions which have been excited in the radial direction experience a potential field which no longer confines the ions axially within the ion trap but which instead acts to extract the ions and hence causes the ions to be ejected axially from the ion trap (2, 3).
摘要翻译：公开了一种质谱仪，其包括四极杆组离子阱（2,3），其中在离子阱（4,5）的出口产生一个电势场，该离子阱在一个径向方向上随着半径的增加而减小。离子阱（2,3）内的离子质量选择性地沿径向激发。已经在径向方向被激发的离子经历了不再将离子轴向限定在离子阱内的势场，而是作用于提取离子并因此导致离子从离子阱（2,3）轴向地排出，。

54. 发明申请

US20100148056A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100148056A1
公开(公告)日：2010-06-17
申请号：US12516610
申请日：2007-12-14
申请人： Daniel James Kenny , Jason Lee Wildgoose , Martin Green
发明人： Daniel James Kenny , Jason Lee Wildgoose , Martin Green
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap (7) or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode (2) which forms part of the Time of Flight mass analyser. Ions in the pulse or packet of ions which is released become temporally dispersed and the orthogonal acceleration electrode (2) is energised multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译：公开了一种质谱仪，其包括正交加速时间飞行质量分析器。从离子阱（7）或替代地从布置在作为飞行时间质量分析器的一部分的正交加速电极（2）的上游的行波离子导向器释放脉冲或包离子。释放的脉冲或离子束中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极（2）被多次通电。

55. 发明申请

US20100038530A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100038530A1
公开(公告)日：2010-02-18
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap (1) is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap (1) by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap (1). A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap (1). The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap (1) in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱（1），其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子在径向上被限制在离子导向器或离子阱（1）内。沿离子导向器或离子阱（1）的轴向长度的至少一部分保持静电势阱。沿离子导向器或离子阱（1）的轴向长度的至少一部分施加时变均匀电场。静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱（1）喷出。

56. 发明申请

US20100032561A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100032561A1
公开(公告)日：2010-02-11
申请号：US12518291
申请日：2007-12-12
申请人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： G01N27/622 , G01N27/624 , H01J49/062 , H01J49/4235
摘要： A mass spectrometer is disclosed comprising a device (2) which is operable in a first mode of operation to separate ions temporally according to their ion mobility by applying a continuous axial electric field. The device (2) is also operable in a second mode of operation wherein ions are separated temporally according to the their mass to charge ratio by pulsing an applied axial electric field ON and OFF.
摘要翻译：公开了一种质谱仪，其包括可在第一操作模式中操作的装置（2），其通过施加连续轴向电场根据其离子迁移率暂时分离离子。装置（2）还可在第二操作模式中操作，其中通过脉冲施加的轴向电场ON和OFF，离子根据其质荷比逐时分离。

57. 发明申请

US20090114808A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090114808A1
公开(公告)日：2009-05-07
申请号：US11916430
申请日：2006-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

58. 发明授权

US09190251B2 Pre-scan for mass to charge ratio range 有权
标题翻译：预扫描质量与充电比例范围
公开(公告)号：US09190251B2
公开(公告)日：2015-11-17
申请号：US14004520
申请日：2012-03-13
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0031
摘要： A method of mass spectrometry is disclosed comprising performing a first analysis of a sample of ions wherein one or more parameters are scanned and/or ions are sorted according to one or more parameters during the first analysis. One or more ranges of interest of the one or more parameters from the first analysis are then automatically determined. A second subsequent analysis of the sample of ions is then automatically performed, wherein the second analysis is restricted to one or more of the ranges of interest of the one or more parameters.
摘要翻译：公开了一种质谱法，其包括在第一次分析期间根据一个或多个参数对离子样品进行第一次分析，其中扫描一个或多个参数和/或离子。然后自动确定来自第一次分析的一个或多个参数的一个或多个感兴趣范围。然后自动执行离子样品的第二次后续分析，其中第二分析限于一个或多个参数的一个或多个感兴趣的范围。

59. 发明授权

US09111654B2 DC ion guide for analytical filtering/separation 有权
标题翻译：用于分析过滤/分离的直流离子导向器
公开(公告)号：US09111654B2
公开(公告)日：2015-08-18
申请号：US14003487
申请日：2012-03-07
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26 , G21K1/00 , H01J49/42 , H01J49/28
CPC分类号： G21K1/00 , H01J49/062 , H01J49/28 , H01J49/427
摘要： An ion guide is disclosed comprising a plurality of electrodes. A first device is arranged and adapted to apply a RF voltage to at least some of the electrodes in order to form, in use, a pseudo-potential well which acts to confine ions in a first direction within the ion guide. A second device is arranged and adapted to apply a DC voltage to at least some of the electrodes in order to form, in use, a DC potential well which acts to confine ions in a second direction within the ion guide. A third device is arranged and adapted to cause ions having desired or undesired mass to charge ratios to be mass to charge ratio selectively ejected from the ion guide in the second direction.
摘要翻译：公开了一种离子导向器，其包括多个电极。第一装置被布置并适于将RF电压施加到至少一些电极，以在使用中形成用于将离子限制在离子导向器内的第一方向上的伪电位阱。第二装置被布置并适于将DC电压施加到至少一些电极，以在使用中形成用于在离子导向器内沿第二方向限制离子的DC势阱。第三装置被布置并适于使具有期望或不需要的质量的充电比例的离子成为从第二方向从离子导向器选择性地喷射的质荷比。

60. 发明申请

US20140326867A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140326867A1
公开(公告)日：2014-11-06
申请号：US14270433
申请日：2014-05-06
申请人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Raymond Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

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