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71. 发明授权

US06762404B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06762404B2
公开(公告)日：2004-07-13
申请号：US10178347
申请日：2002-06-25
申请人： Robert Harold Bateman , Kevin Giles , Steve Pringle
发明人： Robert Harold Bateman , Kevin Giles , Steve Pringle
IPC分类号： H01J4900
CPC分类号： H01J49/005 , H01J49/065
摘要： A mass spectrometer includes a fragmentation cell having a plurality of ring or plate-like electrodes with apertures through which ions are transmitted. An axial DC gradient is preferably maintained along at least a portion of the length of the fragmentation cell in order to improve the transit time of ions through the device.
摘要翻译：质谱仪包括具有多个具有孔的环状或板状电极的分裂单元，离子被透过。轴向DC梯度优选沿破碎细胞的长度的至少一部分保持，以便改善离子通过装置的通过时间。

72. 发明授权

US09293314B2 Photo-dissociation of proteins and peptides in a mass spectrometer 有权
标题翻译：蛋白质和肽在质谱仪中的光解离
公开(公告)号：US09293314B2
公开(公告)日：2016-03-22
申请号：US14130428
申请日：2012-07-06
申请人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
发明人： Daniel James Kenny , Paul Murray , Keith Richardson , Kevin Giles , Jeffery Mark Brown
IPC分类号： H01J49/06 , H01J49/00 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/42
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.
摘要翻译：公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。

73. 发明授权

US09123518B2 Curved ion guide with non mass to charge ratio dependent confinement 有权
标题翻译：具有非质荷比依赖性限制的弯曲离子导向器
公开(公告)号：US09123518B2
公开(公告)日：2015-09-01
申请号：US14001078
申请日：2012-02-24
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose , David. J. Langridge
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose , David. J. Langridge
IPC分类号： H01J49/26 , H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/065 , H01J49/26 , H01J49/42
摘要： A non-linear ion guide is disclosed comprising a plurality of electrodes. An ion guiding region is arranged between the electrodes, and the ion guiding region curves at least in a first direction. A DC voltage is applied to at least some of the electrodes in order to form a DC potential well which acts to confine ions within the ion guiding region in the first direction.
摘要翻译：公开了一种包括多个电极的非线性离子导向器。离子引导区域布置在电极之间，并且离子引导区域至少沿第一方向弯曲。 DC电压被施加到至少一些电极，以便形成用于将离子限制在第一方向上的离子引导区域内的DC势阱。

74. 发明授权

US08334502B2 Apparatus comprising an ion mobility spectrometer 有权
标题翻译：装置包括离子迁移谱仪
公开(公告)号：US08334502B2
公开(公告)日：2012-12-18
申请号：US13297791
申请日：2011-11-16
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： H01J49/0481 , G01N27/622 , H01J49/004 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimizes ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber.
摘要翻译：公开了一种质谱仪，其包括第一室和第二室。第二室位于第一室的下游，并且在两个室之间设置室间孔。离子导向器位于第一室中，离子迁移谱仪位于第二室中。氦气被提供到第一室。当离子从相对低的压力区域向离子迁移谱仪加速时，它们最初通入第一室。当离子加速到相对高的压力区域时，设置在第一室中的氦气最小化离子碎片和离子鉴别效应。然后离子通过离子导向器传输并随后传输到位于第二室中的离子迁移谱仪。

75. 发明授权

US08299422B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08299422B2
公开(公告)日：2012-10-30
申请号：US12917720
申请日：2010-11-02
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason L. Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason L. Wildgoose
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪或分离器，以及布置在离子迁移谱仪或分离器下游的离子导向器。在离子导向器中产生多个轴向势阱，使得从离子迁移谱仪或分离器接收的离子变得限制在单独的轴向势阱中。潜在的孔保持从离子迁移谱仪或分离器接收的离子的保真度和/或组成。势阱沿离子导向器的长度平移。

76. 发明申请

US20110127416A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110127416A1
公开(公告)日：2011-06-02
申请号：US12528203
申请日：2008-02-25
申请人： Iain Campuzano , Kevin Giles , Chris Hughes
发明人： Iain Campuzano , Kevin Giles , Chris Hughes
IPC分类号： B01D59/44 , H01J49/04
CPC分类号： H01J49/0481 , H01J49/0431 , H01J49/067
摘要： A mass spectrometer is disclosed comprising a sampling cone (3) and a cone-gas cone (4) wherein, in use, sulphur hexa fluoride (‘SF6’) is supplied as a cone gas (5) to the annulus between the cone-gas cone (4) and the sampling cone (3) in order to improve the transmission of high molecular mass ions passing through the sampling cone (3) into and through subsequent stages of the mass spectrometer.
摘要翻译：公开了一种质谱仪，其包括采样锥体（3）和锥形气体锥体（4），其中在使用中将六氟化硫（“SF 6”）作为锥形气体（5）供应到圆锥体气体锥体（4）和采样锥体（3），以改善通过采样锥体（3）进入质谱仪后续阶段的高分子量离子的透射。

77. 发明授权

US07829849B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07829849B2
公开(公告)日：2010-11-09
申请号：US11816221
申请日：2006-02-14
申请人： Kevin Giles
发明人： Kevin Giles
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , G01N27/624
摘要： A device (6) for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device (6) comprises an upper electrode (7a), a lower electrode (7b) and a plurality of intermediate electrodes (8). An asymmetric voltage waveform is applied to the upper electrode (7a) and a DC compensating voltage is applied to the lower electrode (7b).
摘要翻译：公开了一种用于根据离子迁移率的差异分离离子作为电场强度的函数的装置（6）。装置（6）包括上电极（7a），下电极（7b）和多个中间电极（8）。对上部电极（7a）施加非对称电压波形，向下部电极（7b）施加直流补偿电压。

78. 发明申请

US20100108879A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100108879A1
公开(公告)日：2010-05-06
申请号：US12514972
申请日：2007-11-15
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。碰撞室（10）布置在离子门（9）的下游。离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。

79. 发明申请

US20100108878A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100108878A1
公开(公告)日：2010-05-06
申请号：US11720771
申请日：2005-12-07
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
IPC分类号： H01J49/26 , H01J49/34
CPC分类号： H01J49/0045 , G01N27/622 , H01J49/004 , H01J49/022 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter (7), a collision cell (8), an ion mobility spectrometer or separator, an ion guide or collision cell (13) arranged downstream of the ion mobility spectrometer or separator, a second quadrupole rod set mass filter (16) and an ion detector (15).
摘要翻译：公开了一种质谱仪，其包括第一四极杆组质量过滤器（7），碰撞池（8），离子迁移谱仪或分离器，位于离子迁移谱仪或分离器下游的离子导向器或碰撞池（13）第二四极杆组质量过滤器（16）和离子检测器（15）。

80. 发明授权

US07622711B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07622711B2
公开(公告)日：2009-11-24
申请号：US11574554
申请日：2005-09-14
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevin Giles , Robert Harold Bateman
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevin Giles , Robert Harold Bateman
IPC分类号： B01D59/44
CPC分类号： H01J49/005
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (3) arranged upstream of a collision or fragmentation cell (5). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (3). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (3) is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell (5).
摘要翻译：公开了一种质谱仪，其包括设置在碰撞或破碎电池（5）的上游的离子迁移谱仪或分离器（3）。离子在离子迁移谱仪或分离器（3）内根据其离子迁移率分离。离子离子迁移谱仪或分离器（3）离子的动能随时间呈线性增加，以优化离子进入碰撞或破碎电池（5）时的碎裂能。

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