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    • 49. 发明授权
    • Apo A-I mimetic peptides and methods of treatment
    • Apo A-I模拟肽和治疗方法
    • US07985727B1
    • 2011-07-26
    • US11858851
    • 2007-09-20
    • Katsuyuki MuraseLi ZhaoIrina AstafievaPaul M. Consigny
    • Katsuyuki MuraseLi ZhaoIrina AstafievaPaul M. Consigny
    • A61K38/10A61K31/661
    • A61K38/17A61K31/661A61K38/10A61K38/1709
    • A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
    • 一种方法,包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1(Apo A-I)模拟肽引入特定区域的血管壁,其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI(Apo AI)模拟肽或Apo AI合成肽和Acyl CoA胆固醇:酰基转移酶(ACAT)抑制剂的组合的组合物,其形式适于递送到血管中,所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物,其包含适于递送至血管的形式的载脂蛋白A-1(Apo AI)合成肽,所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体, Apo AI的螺旋9。
    • 50. 发明申请
    • PACKET COALESCING
    • 包装包装
    • US20110090920A1
    • 2011-04-21
    • US12980682
    • 2010-12-29
    • Srihari MakineniRavi IyerDave MinturnSujoy SenDonald NewellLi Zhao
    • Srihari MakineniRavi IyerDave MinturnSujoy SenDonald NewellLi Zhao
    • H04L12/66
    • H04L45/74H04L49/20H04L69/16H04L69/161H04L69/166
    • In general, in one aspect, the disclosures describes a method that includes receiving multiple ingress Internet Protocol packets, each of the multiple ingress Internet Protocol packets having an Internet Protocol header and a Transmission Control Protocol segment having a Transmission Control Protocol header and a Transmission Control Protocol payload, where the multiple packets belonging to a same Transmission Control Protocol/Internet Protocol flow. The method also includes preparing an Internet Protocol packet having a single Internet Protocol header and a single Transmission Control Protocol segment having a single Transmission Control Protocol header and a single payload formed by a combination of the Transmission Control Protocol segment payloads of the multiple Internet Protocol packets. The method further includes generating a signal that causes receive processing of the Internet Protocol packet.
    • 一般来说,一方面,本公开内容描述了一种方法,其包括接收多个入口因特网协议分组,所述多个入口因特网协议分组中的每一个具有因特网协议报头和具有传输控制协议报头和传输控制的传输控制协议段 协议有效载荷,其中属于相同传输控制协议/因特网协议的多个分组流。 该方法还包括准备具有单个因特网协议报头的互联网协议分组和具有单个传输控制协议报头的单个传输控制协议段和由多个因特网协议分组的传输控制协议段有效载荷的组合形成的单个有效载荷 。 该方法还包括产生导致因特网协议分组的接收处理的信号。