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21. 发明申请

US20100237237A1 TANDEM ION TRAPPING ARRANGEMENT 有权
公开(公告)号：US20100237237A1
公开(公告)日：2010-09-23
申请号：US12676154
申请日：2008-09-03
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/02
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/025 , H01J49/26 , H01J49/4265 , H01J49/427
摘要： A mass spectrometer is disclosed comprising a first storage ion trap (2) arranged upstream of a high performance analytical ion trap (3). According to an embodiment ions are simultaneously scanned from both the first and second ion trap (2, 3). At any instant in time the quantity of charge present within the second ion trap (3) is limited or restricted so that the second ion trap (3) does not suffer from space charge saturation effects and hence the performance of the second ion trap (3) is not degraded.
摘要翻译：公开了一种质谱仪，其包括设置在高性能分析离子阱（3）上游的第一存储离子阱（2）。根据一个实施例，离子同时从第一和第二离子阱（2,3）扫描。在任何时刻，存在于第二离子阱（3）内的电荷量被限制或限制，使得第二离子阱（3）不会受到空间电荷饱和效应的影响，因此第二离子阱（3）的性能）没有退化。

22. 发明授权

US09425035B2 Ion trap with spatially extended ion trapping region 有权
标题翻译：离子阱具有空间延伸的离子捕获区域
公开(公告)号：US09425035B2
公开(公告)日：2016-08-23
申请号：US14240586
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , H01J49/40
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比的选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

23. 发明授权

US09048081B2 Fast pushing time of flight mass spectrometer combined with restricted mass to charge ratio range delivery 有权
标题翻译：快速推进飞行时间质谱仪结合限制质量与电荷比范围传送
公开(公告)号：US09048081B2
公开(公告)日：2015-06-02
申请号：US13997556
申请日：2011-12-22
申请人： Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose
发明人： Martin Raymond Green , Daniel James Kenny , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/02 , H01J49/00
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0086
摘要： Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyzer. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T1, wherein ions having the lowest mass to charge ratio in the first group of ions have a time of flight ΔT1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight ΔT1max through the time of flight region. The control system applies a second extraction pulse to the acceleration electrode at a subsequent second time T2, wherein ΔT1max−ΔT1min≦T2−T1
摘要翻译：具有有限范围的质荷比的离子被传送到飞行时间质量分析器的加速区域。控制系统将第一提取脉冲施加到加速电极，以便在第一时间T1将第一组离子加速到飞行时间区域，其中在第一组离子中具有最低质荷比的离子具有飞行时间Dgr;飞行时间T1min，第一组离子具有最高质荷比的离子在飞行时间段内具有飞行时间Dgr; T1max。控制系统在随后的第二时间T2向加速电极施加第二提取脉冲，其中＆Dgr; T1max-＆Dgr; T1min＆N1; T2-T1 <＆Dgr; T1max。

24. 发明授权

US08859955B2 Function switching with fast asynchronous acquisition 有权
标题翻译：功能切换采用快速异步采集
公开(公告)号：US08859955B2
公开(公告)日：2014-10-14
申请号：US14113160
申请日：2012-04-20
申请人： Martin Raymond Green
发明人： Martin Raymond Green
IPC分类号： B01D59/44 , H01J49/40 , H01J49/26 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/401
摘要： A method of analyzing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions.
摘要翻译：公开了分析样品的方法，其包括通过质谱仪传输第一离子群并切换质谱仪的状态或模式以产生第二离子群。相对于质谱仪的状态或模式的切换，异步获取连续的质谱流。然后对质谱数据流进行后处理，以产生主要对应于第一和第二离子群的质谱。

25. 发明授权

US08829433B2 Ion mobility separator with variable effective length 有权
标题翻译：具有可变有效长度的离子迁移分离器
公开(公告)号：US08829433B2
公开(公告)日：2014-09-09
申请号：US14004486
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/36
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。第一装置被布置并适于维持DC电场或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端推到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将一个或多个瞬态DC电压施加到螺旋电极，以促使离子朝向离子迁移分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

26. 发明申请

US20140197308A1 Function Switching With Fast Asynchronous Acquisition 有权
标题翻译：快速异步采集功能切换
公开(公告)号：US20140197308A1
公开(公告)日：2014-07-17
申请号：US14113160
申请日：2012-04-20
申请人： Martin Raymond Green
发明人： Martin Raymond Green
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/401
摘要： A method of analysing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions.
摘要翻译：公开了分析样品的方法，其包括通过质谱仪传输第一离子群并切换质谱仪的状态或模式以产生第二离子群。相对于质谱仪的状态或模式的切换，异步获取连续的质谱流。然后对质谱数据流进行后处理，以产生主要对应于第一和第二离子群的质谱。

27. 发明授权

US08658971B2 Method of processing mass spectral data 有权
标题翻译：处理质谱数据的方法
公开(公告)号：US08658971B2
公开(公告)日：2014-02-25
申请号：US13375056
申请日：2010-05-28
申请人： Martin Raymond Green , Garry Michael Scott , Nicholas Lester St Hill
发明人： Martin Raymond Green , Garry Michael Scott , Nicholas Lester St Hill
IPC分类号： H01J49/40
CPC分类号： H01J49/0036 , G06K9/0053 , H01J49/40
摘要： A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time To and peak area So of one or more peaks in the first set of peaks are determined thereby forming a first list of data pairs, each data pair comprising an arrival time value and a peak area value. One or more data pairs from the first list are then filtered out thereby forming a second reduced list, wherein a data pair is filtered out, attenuated or otherwise rejected from the first list if the peak area value of a data pair in the first list is determined to be less than a threshold peak area.
摘要翻译：公开了一种处理质谱数据的方法，包括数字化从离子检测器输出的第一信号以产生第一数字化信号。检测第一数字化信号中的第一组峰值，并确定第一组峰值中的一个或多个峰值的到达时间To和峰值面积So，从而形成第一数据对列表，每个数据对包括到达时间值和峰面积值。然后将来自第一列表的一个或多个数据对过滤掉，从而形成第二缩减列表，其中如果第一列表中的数据对的峰值面积值是第一列表中的峰值面积值，则数据对被滤除，衰减或以其他方式从第一列表中被拒绝确定为小于阈值峰面积。

28. 发明授权

US08344316B2 Method of avoiding space charge saturation effects in an ion trap 有权
标题翻译：避免离子阱中空间电荷饱和效应的方法
公开(公告)号：US08344316B2
公开(公告)日：2013-01-01
申请号：US12997347
申请日：2009-06-08
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42 , B01D59/44
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects.
摘要翻译：质谱仪包括布置在分析第二离子阱的上游的第一离子阱。第一离子阱的充电容量被设定为使得如果存储在第一离子阱内的所有离子直到第一离子阱的充电容量极限，则转移到第二离子阱，则分析性能由于空间电荷效应，第二离子阱基本上不会劣化。

29. 发明授权

US08283626B2 Electron transfer dissociation device 有权
标题翻译：电子转移离解装置
公开(公告)号：US08283626B2
公开(公告)日：2012-10-09
申请号：US12937806
申请日：2009-04-03
申请人： Jeffery Mark Brown , Martin Raymond Green
发明人： Jeffery Mark Brown , Martin Raymond Green
IPC分类号： H01J49/26
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

30. 发明申请

US20110303838A1 Method Of Avoiding Space Charge Saturation Effects In An Ion Trap 有权
标题翻译：在离子阱中避免空间电荷饱和效应的方法
公开(公告)号：US20110303838A1
公开(公告)日：2011-12-15
申请号：US12997347
申请日：2009-06-08
申请人： Martin Raymond Green , Jason Lee Wildgoose
发明人： Martin Raymond Green , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer is provided comprising a first ion trap (2) arranged upstream of an analytical second ion trap (5). The charge capacity of the first ion trap (2) is set at a value such that if all the ions stored within the first ion trap (2) up to the charge capacity limit of the first ion trap (2) are then transferred to the second ion trap (5), then the analytical performance of the second ion trap (5) is not substantially degraded due to space charge effects.
摘要翻译：提供质谱仪，其包括布置在分析性第二离子阱（5）上游的第一离子阱（2）。将第一离子阱（2）的充电容量设定为使得如果存储在第一离子阱（2）内的所有离子直到第一离子阱（2）的充电容量极限，则转移到第二离子阱（5），则由于空间电荷效应，第二离子阱（5）的分析性能基本上不劣化。

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