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1. 发明申请

WO2018094409A1 HYPERELASTIC BINDER FOR PRINTED, STRETCHABLE ELECTRONICS 审中-公开
公开(公告)号：WO2018094409A1
公开(公告)日：2018-05-24
申请号：PCT/US2017062860
申请日：2017-11-21
申请人： UNIV CALIFORNIA , YIN LU
发明人： YIN LU , WANG JOSEPH , KUMAR RAJAN , MENG YING , SHIN JAE
IPC分类号： C09D11/52 , H01R12/59
CPC分类号： H05K1/0283 , A61B5/1477 , A61B5/14865 , A61B2562/164 , A61B2562/166 , A61F13/4902 , C01B32/158 , C08F297/046 , C08L53/02 , H01M4/38 , H01M4/48 , H01M4/622 , H01M4/663 , H01M4/666 , H01M4/668 , H01M10/0565 , H01M10/24 , H05K1/028 , H05K1/0393 , H05K1/118 , H05K1/16 , H05K3/326 , H05K2201/0133
摘要： Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.

2. 发明申请

WO2017091630A4 TRACKING AND MANIPULATING CELLULAR RNA VIA NUCLEAR DELIVERY OF CRISPR/CAS9 审中-公开
标题翻译：通过核交付CRISPR / CAS9追踪和操纵细胞RNA
公开(公告)号：WO2017091630A4
公开(公告)日：2017-08-24
申请号：PCT/US2016063429
申请日：2016-11-22
申请人： UNIV CALIFORNIA , FANG MARK , BATRA RANJAN
发明人： FANG MARK , BATRA RANJAN , YEO GENE , NELLES DAVID
IPC分类号： C12N15/11 , C07K19/00 , C12N15/113 , C12N15/62
CPC分类号： C12N9/22 , A61K38/465 , A61K48/0058 , C07K2319/09 , C07K2319/80 , C12N15/111 , C12N15/113 , C12N2310/10 , C12N2310/20
摘要： Cas9 polypeptides which target RNA and methods of using them are provided.
摘要翻译：提供靶向RNA的Cas9多肽及其使用方法。

3. 发明申请

WO2017096431A8 PROTEINACEOUS MOLECULES AND METHODS OF USE 审中-公开
标题翻译：蛋白质分子及其使用方法
公开(公告)号：WO2017096431A8
公开(公告)日：2017-07-06
申请号：PCT/AU2016051213
申请日：2016-12-09
申请人： UNIV QUEENSLAND , THE FLOREY INST OF NEUROSCIENCE AND MENTAL HEALTH , UNIV JOHNS HOPKINS , UNIV CALIFORNIA
发明人： PETROU STEVEN , KING GLENN , BOSMANS FRANK , JULIUS DAVID , OSTEEN JEREMIAH , ZHANG CHUCHU
IPC分类号： C07K14/435 , A61K38/17 , A61P25/08 , A61P25/28
CPC分类号： C07K14/43518 , A61K38/00
摘要： This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.
摘要翻译：本发明涉及肽及其用于调节钠通道的用途。更具体地说，本发明涉及肽及其在增强Nav1.1活性和治疗或预防Nav1.1活性相关病症的方法中的用途。

4. 发明申请

WO2017070302A3 MODULATION OF MICRORNA 184 TO TREAT PATHOLOGICAL LYMPHANGIOGENESIS 审中-公开
标题翻译： MICRORNA 184调节病理性淋巴血管生成
公开(公告)号：WO2017070302A3
公开(公告)日：2017-06-15
申请号：PCT/US2016057838
申请日：2016-10-20
申请人： UNIV CALIFORNIA
发明人： CHEN LU , GRIMALDO SAMMY
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： A61K31/7088 , C12N15/113 , C12N2310/141
摘要： The present invention provides in certain embodiments a method of suppressing pathological lymphatic formation in a tissue or organ in a mammal in need thereof comprising administering a therapeutic agent comprising Mir-184, pri-Mir-184, a Mir-184 mimic, or a vector comprising an expression cassette comprising a promoter and a nucleic acid encoding Mir-184, pri-Mir-184, or a Mir-184 mimic.
摘要翻译：在某些实施方案中，本发明提供了抑制有需要的哺乳动物的组织或器官中的病理性淋巴形成的方法，其包括施用包含Mir-184，pri-Mir-184，Mir-184模拟物或载体的治疗剂包含含有启动子和编码Mir-184，pri-Mir-184或Mir-184模拟物的核酸的表达盒。

5. 发明申请

WO2017058340A3 SYSTEM AND METHOD FOR LOCALIZATION AND TRACKING USING GNSS LOCATION ESTIMATES, SATELLITE SNR DATA AND 3D MAPS 审中-公开
标题翻译：使用GNSS位置估计，卫星SNR数据和3D地图进行定位和跟踪的系统和方法
公开(公告)号：WO2017058340A3
公开(公告)日：2017-06-01
申请号：PCT/US2016042588
申请日：2016-07-15
申请人： UNIV CALIFORNIA
发明人： IRISH ANDREW , ISAACS JASON , MADHOW UPAMANYU
IPC分类号： G01S19/42 , G01S19/24
CPC分类号： G01S19/22 , G01S19/42 , G01S19/425 , G01S19/428 , G01S19/46
摘要： A method of determining location of a user device includes receiving global navigation satellite system (GNSS) fix data that represents GNSS calculated position of the user device. The method further includes receiving signal strength data associated with each satellite communicating with the user device, and receiving map information regarding environment surrounding the user device. The received GNSS fix data and signal strength data is provided to a non-linear filter, wherein the non-linear filter fuses the GNSS fix data and signal strength data to generate an updated position estimate of the user device. In addition, the non-linear filter utilizes probabilistic shadow matching estimates that represent a likelihood of received signal strength data as a function of hypothesized user device locations within the environment described by the received map information.
摘要翻译：确定用户设备的位置的方法包括接收表示用户设备的GNSS计算的位置的全球导航卫星系统（GNSS）固定数据。该方法还包括接收与每个与用户设备通信的卫星相关的信号强度数据，并且接收关于用户设备周围的环境的地图信息。接收的GNSS固定数据和信号强度数据被提供给非线性滤波器，其中非线性滤波器将GNSS固定数据和信号强度数据融合以生成用户设备的更新的位置估计。另外，非线性滤波器利用概率阴影匹配估计，其表示接收信号强度数据的可能性，作为由所接收地图信息描述的环境内的假定用户设备位置的函数。

6. 发明申请

WO2017059130A3 GAS PURIFICATION WITH DIAMINE-APPENDED METAL-ORGANIC FRAMEWORKS 审中-公开
标题翻译：含有二胺的金属有机框架气体净化
公开(公告)号：WO2017059130A3
公开(公告)日：2017-05-26
申请号：PCT/US2016054530
申请日：2016-09-29
申请人： UNIV CALIFORNIA , CHEVRON USA INC
发明人： LONG JEFFREY R , MCDONALD THOMAS M , SIEGELMAN REBECCA L , THOMPSON JOSHUA A
IPC分类号： C07F3/00 , B01D53/02 , C09B57/10
CPC分类号： C07F3/003
摘要： The disclosure provides for diamine-appended metal-organic frameworks (MOFs), methods of making thereof, and methods of use thereof.
摘要翻译：本公开提供了附加二胺的金属有机骨架（MOF），其制备方法以及其使用方法。

7. 发明申请

WO2016049430A8 METHODS TO PRODUCE ULTRA-THIN METAL NANOWIRES FOR TRANSPARENT CONDUCTORS 审中-公开
标题翻译：生产超薄金属纳米线用于透明导体的方法
公开(公告)号：WO2016049430A8
公开(公告)日：2017-04-20
申请号：PCT/US2015052180
申请日：2015-09-25
申请人： UNIV CALIFORNIA
发明人： YANG PEIDONG , SUN JIANWEI , YU YI , CUI FAN
IPC分类号： C07F1/08 , B22F1/00 , B22F9/24 , C01G3/00 , C01G3/04 , C01G3/05 , C01G3/08 , C07F7/08 , C07F7/12 , C07F7/18
CPC分类号： C07F7/0896 , B22F1/0025 , B22F9/24 , B82B3/00 , C07F1/08 , C07F7/12 , C07F7/1844 , H01B1/02
摘要： The disclosure provides methods to produce ultrathin metal nanowires and methods to produce ultrathin copper elongated nanostructures. Also claimed are the metal nanowires produced by these methods, and the use of the metal nanowires as transparent conductors. The claimed method comprises the steps of: a) forming a reaction mixture comprising a silane-based reducing agent, a copper metal salt and a surface ligand, wherein the surface ligand may also be a solvent; and b) heating and maintaining the reaction mixture at an elevated temperature between 1 to 48 hours with or without stirring. Examples for copper metal salts are Cul, CuBr, CuCI, CuF, CuSCN, CuCI2, CuBr2, CuF2, Cu(OH)2, Cu-D-gluconate, CuMo04, Cu(N03)2, Cu(Clo4) 2, CuP207, CuSe03, CuS04, Cu-tartrate, Cu(BF4)2, Cu(NH3) 4SO4, and including any hydrates of the foregoing. Examples for silane-based reducing agents are: trietylsilane, trimethylsilane, triisopropylsilane, triphenylsilane, tri-n-propylsilane, tri-n-hexylsilane, triethoxysilane, tris(trimethylsiloxy)silane, tris(trimethylsilyl)silane, di-tert- butylmethylsilane, diethylmethylsilane, diisopropylchlorosilane, dimethylchlorosilane, dimethylethoxysilane, diphenylmethylsilane, ethyldimethylsilane, ethyldichlorosilane, methyldichlorosilane, methyldiethoxysilane, octadecyldimethylsilane, phenyldimethylsilane, phenylmethylchlorosilane, l,l,4,4-tetramethyl-l,4-disilabutane, trichlorosilane, dimethylsilane, di-tert-butylsilane, dichlorosilane, diethylsilane, diphenylsilane, phenylmethylsilane, n-hexylsilane, n- octadecylsilane, n-octylsilane, and phenylsilane. Examples for surface ligands are oleylamine, trioctylphosphine oxide, oleic acid, 1,2-hexadecanediol, trioctylphosphine, or any combination of the foregoing. Examples for devices where said transparent conductors are of use are: LCD display, a LED display, a photovoltaic device, a touch panel, a solar panel, a light emitting diode (LED), an organic light emitting diode (OLED), an OLED display, and a electrochromic window.
摘要翻译：本公开提供了生产超薄金属纳米线的方法和生产超薄铜细长纳米结构的方法。还要求保护通过这些方法生产的金属纳米线，以及使用金属纳米线作为透明导体。要求保护的方法包括以下步骤：a）形成包含硅烷基还原剂，铜金属盐和表面配体的反应混合物，其中表面配体也可以是溶剂; 和b）在搅拌或不搅拌下将反应混合物在1至48小时的升高的温度下加热并保持。铜金属盐的例子是CuI，CuBr，CuCl，CuF，CuSCN，CuCl 2，CuBr 2，CuF 2，Cu（OH）2，Cu-D-葡萄糖酸盐，CuMoO 4，Cu（NO 3）2，Cu（Clo 4）2，CuP 2 O 7， CuSeO 3，CuSO 4，Cu-酒石酸盐，Cu（BF 4）2，Cu（NH 3）4 SO 4，并且包括前述的任何水合物。为基于硅烷的还原剂的实例是：trietylsilane，三甲基硅烷，三异丙基硅烷，三苯基硅烷，三 - 正丙基硅烷，三 - 正己基硅烷，三乙氧基硅烷，三（三甲基硅氧基）硅烷，三（三甲基硅烷基）硅烷，二 - 叔butylmethylsilane，diethylmethylsilane ，diisopropylchlorosilane，二甲基氯硅烷，二甲基乙氧基硅烷，diphenylmethylsilane，ethyldimethylsilane，乙基二氯硅烷，甲基二氯硅烷，甲基二乙氧基硅烷，octadecyldimethylsilane，苯基二甲基硅烷，phenylmethylchlorosilane，1,1-，4,4-四甲基-1,4-二硅杂丁烷，三氯硅烷，二甲基硅烷，二叔丁基硅烷，二氯二乙基硅烷，二苯基硅烷，苯基甲基硅烷，正己基硅烷，正十八烷基硅烷，正辛基硅烷和苯基硅烷。表面配体的实例为油胺，氧化三辛基膦，油酸，1,2-十六烷二醇，三辛基膦或前述的任何组合。其中所述透明导体有用的器件的例子是：LCD显示器，LED显示器，光伏器件，触摸板，太阳能电池板，发光二极管（LED），有机发光二极管（OLED），OLED 显示屏和电致变色窗口。

8. 发明申请

WO2017015429A3 GLUCOSE METABOLISM WITH MOLECULAR PURGE VALVE 审中-公开
标题翻译：葡萄糖代谢与分子泵
公开(公告)号：WO2017015429A3
公开(公告)日：2017-03-02
申请号：PCT/US2016043260
申请日：2016-07-21
申请人： UNIV CALIFORNIA
发明人： BOWIE JAMES U , KORMAN TYLER P , OPGENORTH PAUL H
IPC分类号： C12P5/00 , C12P5/02 , C12P19/36
CPC分类号： C12P7/16 , C12P7/625 , Y02E50/10
摘要： Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.
摘要翻译：提供了可以在无细胞系统，细胞系统或其组合中起作用以将糖转化为化学或生物燃料的工程化途径。

9. 发明申请

WO2016191424A3 NOVEL HETEROAROMATIC SILICON-FLUORIDE-ACCEPTORS USEFUL FOR 18F LABELING OF MOLECULES AND BIOMOLECULES, AND METHODS OF PREPARING SAME 审中-公开
标题翻译：用于18F分子和生物分子标记的新型异辛基氟化物受体及其制备方法
公开(公告)号：WO2016191424A3
公开(公告)日：2016-12-29
申请号：PCT/US2016033923
申请日：2016-05-24
申请人： UNIV CALIFORNIA
发明人： WALDMANN CHRISTOPHER MARTIN , TOUTOV ANTON A , MURPHY JENNIFER MARIE , GRUBBS ROBERT H
IPC分类号： C07F7/08 , A61K51/04 , C07F13/00 , C07F19/00
CPC分类号： A61K51/1072 , A61K51/1027 , C07B59/004 , C07F7/12
摘要： The present invention includes novel compounds and compositions including heteroaromatic Silicon-Fluoride- Acceptors, which are useful for PET scanning. The present invention further includes a novel method of 18F imaging for PET scanning, the method comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic SiFAs. In one embodiment the invention is practiced in the form of a kit.
摘要翻译：本发明包括可用于PET扫描的新型化合物和包含杂芳香硅氟化物受体的组合物。本发明还包括用于PET扫描的18F成像的新方法，该方法包括用杂芳族SiFAs制备目标生物配体的缀合物和生物缀合物。在一个实施方案中，本发明以试剂盒的形式实施。

10. 发明申请

WO2016164363A8 METHODS FOR DETERMINING BASE LOCATIONS IN A POLYNUCLEOTIDE 审中-公开
标题翻译：用于确定多核苷酸中碱基位置的方法
公开(公告)号：WO2016164363A8
公开(公告)日：2016-12-01
申请号：PCT/US2016026047
申请日：2016-04-05
申请人： UNIV CALIFORNIA
发明人： JAIN MITEN , OLSEN HUGH EDWARD , AKESON MARK A
IPC分类号： C12M1/34 , C12N11/00 , C12N15/10
CPC分类号： C12Q1/6869 , C12Q1/6827 , C12Q2521/531 , C12Q2525/119 , C12Q2545/101 , C12Q2563/116 , C12Q2565/631 , C12Q2537/164
摘要： Disclosed are methods for polynucleotide sequencing that detect the location of selected nucleobases with greater precision. The methods can be used to determine the location and nature of modified bases in a polynucleotide, that is, non-canonical bases, or to improve accuracy of sequencing of "problem" regions of DNA sequencing such as homopolymers, GC rich areas, etc. The sequencing method exemplified is nanopore sequencing. Nanopore sequencing is used to generate a unique signal at a point in a polynucleotide sequence where an abasic site (AP site, or apurinic or apyrimidinic site) exists. As part of the method, an abasic site is specifically created enzymatically using a DNA glycosylase that recognizes a pre-determined nucleobase species and cleaves the N-glycosidic bond to release only that base, leaving an AP site in its place.
摘要翻译：公开了用于多核苷酸测序的方法，其以更高的精度检测所选核碱基的位置。这些方法可用于确定多核苷酸（即非规范碱基）中修饰碱基的位置和性质，或提高DNA测序“问题”区域测序的准确性，如均聚物，GC富集区等。示例的测序方法是纳米孔测序。纳米孔测序用于在存在脱碱基位点（AP位点或无嘌呤或脱嘧啶位点）的多核苷酸序列中的某一点产生唯一信号。作为该方法的一部分，使用识别预定核碱基物种的DNA糖基化酶酶切地形成脱碱基位点，并切割N-糖苷键以仅释放该碱基，从而将AP位点置于其位置。

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